Improved performance in protein secondary structure prediction by combining multiple predictions.

abstract：:Proteases have been used not only for proteolysis but also in organic solvent-assisted religation processes. Here, we demonstrated the effect of salts on peptide bond resynthesis in Glutathione-S-transferase (GST) and have found it to be in the purview of the Hofmeister phenomena. Our results show that the efficiency ...

journal_title：Protein and peptide letters

authors： Kishan KV,Sharma A

更新日期：2010-01-01 00:00:00

abstract：:Cyclophilin A (CyPA) is a cytosolic receptor of immunosuppressive drug cyclosporin A (CsA) which possesses peptidyl-prodyl cis/trans isomerase (PPIase) activity. The recombinant human CyPA (rhCyPA) gene has been expressed in E. coli M15. Purification was performed using salting-out, as well as Sephacryl S-100 and DEAE...

journal_title：Protein and peptide letters

authors： Zhang XC,Wang WD,Wang JS,Pan JC,Zou GL

更新日期：2011-12-01 00:00:00

abstract：:Behcet's disease (BD) is a recurrent pathema with a typical symptom of inflammation involved in many organs. Previous report indicated that the serum of Korean patients with BD stimulates membrane expression of hnRNP A2/B1 in endothelial cells. In this study, the target 35 kDa recombinant human hnRNP A2/B1 were over-e...

journal_title：Protein and peptide letters

authors： Liang J,Yang W,Meng X,Chen P,Du H

更新日期：2015-01-01 00:00:00

abstract：:To identify proteins involved in the molecular mechanisms of pressure overload-induced heart failure, we quantitatively analyzed the left ventricular proteomic profile in a transverse aortic constriction (TAC) mouse model, a well-established model of cardiac hypertrophy and dysfunction. Multidimensional LC-MS/MS in co...

journal_title：Protein and peptide letters

authors： Guan D,Zhao Y,Zhang Y,Tang D,Wu Q

更新日期：2016-01-01 00:00:00

abstract：:The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...

journal_title：Protein and peptide letters

authors： Koutsas C,Sarigiannis Y,Stavropoulos G,Liakopoulou-Kyriakides M

更新日期：2007-01-01 00:00:00

abstract：:We report the stepwise transformation of a linear peptide epitope recognized by the anti-transforming growth factor alpha monoclonal antibody Tab2 into peptomers and finally into peptoid analogs. The key experiment in this study is the substitution analysis in which each position of the peptide is exchanged by a set o...

journal_title：Protein and peptide letters

authors： Hoffmann B,Ast T,Polakowski T,Reineke U,Volkmer R

更新日期：2006-01-01 00:00:00

abstract：:The high technical standard of current peptide chemistry, which has evolved over the past three decades, has profoundly facilitated the investigation of proteins and their interactions with other molecules at the level of individual amino acids. Using currently available peptide synthesis methods, sequentially continu...

journal_title：Protein and peptide letters

authors： Eichler J

更新日期：2004-08-01 00:00:00

abstract：:Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology ...

journal_title：Protein and peptide letters

authors： Kesari P,Neetu,Sharma A,Katiki M,Kumar P,Gurjar BR,Tomar S,Sharma AK,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:We previously described a potent anthrax toxin inhibitor, based on a phage-library-selected peptide sequence, synthesized as a tetra-branched molecule on a lysine core and further modified for improvement of activity [Pini et al., Biochem. J., 2006, 395, 157]. This branched peptide had very low solubility because of s...

journal_title：Protein and peptide letters

authors： Pini A,Brunetti J,Falciani C,Fabbrini M,Bracci L

更新日期：2008-01-01 00:00:00

abstract：:We present the results of a study on the influence of albumin and prolactin concentrations and intravascular fluid pH on vein permeability for albumin. Permeability conditions were simulated depending on albumin concentration, pH value and prolactin concentration. In research model an in vitro method was applied using...

journal_title：Protein and peptide letters

authors： Dolińska B,Caban A,Cierpka L,Ryszka F

更新日期：2014-01-01 00:00:00

abstract：:Bucain, a potent neurotoxin isolated from the venom of the Malayan krait (Bungarus candidus), induces paralysis and death. Its crystal structure has been determined at 2.10 A resolution and based on the molecular topology and hydrophobicity profile is structurally classified as a three-fingered alpha-neurotoxin posses...

journal_title：Protein and peptide letters

authors： Murakami MT,Kini RM,Arni RK

更新日期：2009-01-01 00:00:00

abstract：:Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...

journal_title：Protein and peptide letters

authors： Agueci F,Polticelli F,Sinibaldi F,Piro MC,Santucci R,Fiorucci L

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorigenesis which is also associated with structural disordered. Intrinsically disordered pro...

journal_title：Protein and peptide letters

authors： Maulik U,Uversky VN,Sen S

更新日期：2018-01-01 00:00:00

abstract：:We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4[29-39]. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, ...

journal_title：Protein and peptide letters

authors： Palladino P,Pedone C,Ragone R,Rossi F,Saviano M,Benedetti E

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...

journal_title：Protein and peptide letters

authors： Wu H,Huang J

更新日期：2018-01-01 00:00:00

abstract：:Porins are integral membrane proteins found in the outer membrane of bacteria, mitochondria and chloroplasts. Herein, we have reviewed sequence and structural understanding about bacterial porins. The first porin structure from Rhodobacter capsulatus at 1.8 Å resolution in 1991 till the recent structural advancement, ...

journal_title：Protein and peptide letters

authors： Kumar A,Bhandari A,Krishnaswamy S

更新日期：2015-01-01 00:00:00

abstract：:Heparin is naturally occurring polysaccharides which interacts with seminal plasma proteins and regulate multiple steps in fertilization process. Qualitative and quantitative information regarding the affinity for heparin-seminal plasma proteins interactions is not generally well documented and there are no reports of...

journal_title：Protein and peptide letters

authors： Kumar V,Yadav VK,Hassan MI,Singh AK,Dey S,Singh S,Singh TP,Yadav S

更新日期：2012-08-01 00:00:00

abstract：:The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...

journal_title：Protein and peptide letters

authors： Saikumari YK,Ravindra G,Balaram P

更新日期：2006-01-01 00:00:00

abstract：:Infections by antibiotic-resistant bacteria are becoming a great risk for human health, leading to an urgent need for new efficient antibacterial therapies. The short, proline-rich antimicrobial peptides from insects gained a lot of interest as a potential antibacterial treatment, having a low toxicity profile and bei...

journal_title：Protein and peptide letters

authors： Stalmans S,Wynendaele E,Bracke N,Knappe D,Hoffmann R,Peremans K,Polis I,Burvenich C,De Spiegeleer B

更新日期：2014-04-01 00:00:00

abstract：:Kappa-conotoxin RIIIJ is a conopeptide to inhibit voltage-gated potassium channels, however, its detailed folding structures have yet to be studied. With the advance in computing power, it is possible to use the HP model to analyze all its possible folding structures. In this study, the amino acid sequences of kappa-c...

journal_title：Protein and peptide letters

authors： Yan S,Wu G

更新日期：2012-05-01 00:00:00

abstract：:Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...

journal_title：Protein and peptide letters

authors： Liao B,Fu X,Cai L,Chen H

更新日期：2014-07-01 00:00:00

abstract：:Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of...

journal_title：Protein and peptide letters

authors： Conlon JM,Al-Ghaferi N,Abraham B,Sonnevend A,King JD,Nielsen PF

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Multiple Sequence Alignment (MSA) is a fundamental task in bioinformatics and is required for many biological analysis tasks. The more accurate the alignments are, the more credible the downstream analyses. Most protein MSA algorithms realign an alignment to refine it by dividing it into two groups horizonta...

journal_title：Protein and peptide letters

authors： Zhan Q,Fu Y,Jiang Q,Liu B,Peng J,Wang Y

更新日期：2020-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) triggers coordinated innate and adaptive response in host cell. HCV genome and proteins of the replicating virus are recognized as non-self-antigens by host cell to activate Toll Like Receptors (TLRs). Activated TLRs ultimately express cytokines, which can clear virus either by activating inter...

journal_title：Protein and peptide letters

authors： Farooqi ZU,Tareen SH,Ahmed J,Zaidi NU

更新日期：2016-01-01 00:00:00

abstract：:Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...

journal_title：Protein and peptide letters

authors： Qi X,Wang J,Meng Q,Liu XQ

更新日期：2011-12-01 00:00:00

abstract：:Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9), a subunit of an Elongin C-cullin-SOCS box (ECS) E3 ubiquitin ligase complex, is believed to be involved in specific substrate-recognition for ubiquitination and degradation. In fact, this specific substrate-recognition is determined by th...

journal_title：Protein and peptide letters

authors： Fei X,Zhang Y,Gu X,Qiu R,Mao Y,Ji C

更新日期：2009-01-01 00:00:00

abstract：:Oblique orientated alpha-helices are highly specialised protein structural elements that penetrate membranes at a shallow angle and are used to promote membrane destabilisation by a number of protein classes. Here, the use of extended hydrophobic moment methodology shows that the amphibian extrudates, aurein 1.2 and c...

journal_title：Protein and peptide letters

authors： Dennison SR,Harris F,Phoenix DA

更新日期：2005-01-01 00:00:00

abstract：:BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...

journal_title：Protein and peptide letters

authors： Liu Z,Yang GZ,Chi CW,Wu XF

更新日期：2002-10-01 00:00:00

abstract：:The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...

journal_title：Protein and peptide letters

authors： Bera S,Gazit E

更新日期：2019-01-01 00:00:00

abstract：:From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studie...

journal_title：Protein and peptide letters

authors： Zhang GZ,Han K

更新日期：2008-01-01 00:00:00