Abstract:
:Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology are thought to have evolved from either one-domain germin predecessor by duplication or by horizontal gene transfer of two-domain gene from bacteria to eukaryotes. Globulins are known to define the nutritional quality of the seeds, however, they are also involved in sucrose binding, desiccation, defense against microbes, hormone binding and oxidative stress etc. Major drawback with globulins is their tendency to bind to IgE. Studying structural-functional behavior of such protein can help in modifying proteins for enhanced functionality in food processing industries.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Kesari P,Neetu,Sharma A,Katiki M,Kumar P,Gurjar BR,Tomar S,Sharma AK,Kumar Pdoi
10.2174/0929866523666161220112641subject
Has Abstractpub_date
2017-01-01 00:00:00pages
267-277issue
3eissn
0929-8665issn
1875-5305pii
PPL-EPUB-80448journal_volume
24pub_type
杂志文章,评审abstract::The immunoglobulin fold (Ig-fold) is a widespread structural motif that is detected in a variety of proteins involved in diversified biological processes. The Ig-fold contains 70-110 residues that are assembled in a characteristic sandwich-like structure formed by two facing β-sheets each made of antiparallel β-strand...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986612802762732
更新日期:2012-10-01 00:00:00
abstract::The superoxide anion radical is a highly reactive toxic species produced during the metabolic processes. A number of copper (II) complexes with amino acids and peptides are known to show superoxide dismutase (SOD) like activity. The design and application of synthetic low molecular weight metal complexes as SOD mimics...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642724
更新日期:2011-12-01 00:00:00
abstract::Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity o...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191014144015
更新日期:2020-01-01 00:00:00
abstract::AB204 is an Activin/BMP2 chimera, which has been found to exhibit a higher activity than Bone Morphogenetic Protein 2 (BMP2) in osteogenic activity. To prepare AB204 for its preclinical studies, AB204 has been characterized in various formulation buffers. We observed that AB204 purified by ion-exchange chromatography ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986652105140218110302
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer. OBJECTIVE:This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170815161621
更新日期:2017-11-17 00:00:00
abstract::Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777790566
更新日期:2006-01-01 00:00:00
abstract::Bromelain inhibitor, "bromein", is a proteinase-inhibitor specific to the cysteine proteinase bromelain from pineapple stem. In the stem, eight bromein isoforms are known to exist, and each isoform has a short peptide (light chain) and a long one (heavy chain) with five disulfide bonds. The three-dimensional structure...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180821115432
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Chickpea is a widely grown legume in India, Australia, Canada, and Mediterranean regions. Seeds of chickpea are good source of protein for both human and animals. Wild relatives of chickpea (Cicer arietinum) are the potential gene pool for crop improvement; however, very little information is available on th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200910164118
更新日期:2020-09-10 00:00:00
abstract::Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cos...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608784246416
更新日期:2008-01-01 00:00:00
abstract::Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190410124642
更新日期:2020-01-01 00:00:00
abstract::The physiological stability curve--a plot of the free energy of unfolding versus temperature--is calculated for hen egg white lysozyme from a combination of extrapolated unfolding thermodynamic data from reversible conditions and isothermal titrations with guanidine hydrochloride. The shape of the curve suggests the e...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777841163
更新日期:2006-01-01 00:00:00
abstract::Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788681724
更新日期:2009-01-01 00:00:00
abstract::The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180917163142
更新日期:2019-01-01 00:00:00
abstract::Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Nucleotide-sugars, lipid phosphate sugars and phosphate sugars can act as activated donor molecules while acceptor substrate...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866511320080003
更新日期:2013-08-01 00:00:00
abstract::This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29/L37a, S29/L38, S29/S27 and S29/...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033408273
更新日期:2003-02-01 00:00:00
abstract::Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9), a subunit of an Elongin C-cullin-SOCS box (ECS) E3 ubiquitin ligase complex, is believed to be involved in specific substrate-recognition for ubiquitination and degradation. In fact, this specific substrate-recognition is determined by th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787601688
更新日期:2009-01-01 00:00:00
abstract::After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785133735
更新日期:2008-01-01 00:00:00
abstract::Cationic antimicrobial peptides (AMPs) are among the best studied antimicrobial factors expressed in the respiratory tract. AMPs are released by epithelial cells and immune cells into the airway surface liquid covering the epithelial surfaces of the lung where they act as endogenous antibiotics. Plenty of studies show...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/09298665113206660100
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Radical Probe Mass Spectrometry (RP-MS) describes a pioneering methodology in structural biology that enables the study of protein structures, their interactions, and dynamics on fast timescales (down to sub-milliseconds). Hydroxyl radicals (•OH) generated directly from water within aqueous solutions induce ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866526666181128124241
更新日期:2019-01-01 00:00:00
abstract::Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and r...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986612799080248
更新日期:2012-02-01 00:00:00
abstract::We report the physical-chemical characterization of the major alcohol-soluble proteins present in seeds of pearl millet (Pennisetum glaucum) by SDS-PAGE, bidimensional gel electrophoresis, MALDI-TOF/MS and RP-HPLC. We demonstrate the presence of three major prolamins, called A-, B- and C-pennisetin with mass values ar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408724
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Peptide: N-glycanase is a deglycosylation enzyme releasing N-glycan from glycoproteins. Although glycan specificity analysis of this enzyme has been reported, recognition requirements for the peptide sequence have not been precisely elucidated. OBJECTIVE:In this study, we carried out peptide specificity ana...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866524666170818160159
更新日期:2017-01-01 00:00:00
abstract::The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320030016
更新日期:2013-03-01 00:00:00
abstract::α-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150209142649
更新日期:2015-01-01 00:00:00
abstract::Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in in...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610792231555
更新日期:2010-10-01 00:00:00
abstract::Coordination of cell growth and cell division is very important for living organisms in order for these to develop harmonically. The present research is concerned with the purification and characterization of a new peptide hormone, namely ZmIGF (Zea mays insulin-like growth factor), which regulates growth and cell div...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611794328636
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Bursa of Fabricius plays the vital functions on B cell development and antibody production in poultry. The bursal-derived peptide plays the essential roles on avian immature B cell development. OBJECTIVES:Here we explored the functions of the recently reported bursal nonapeptide (BP9) on the antibody produc...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190730101455
更新日期:2019-01-01 00:00:00
abstract::An efficient preparation of Periplaneta americana nymphae allergen, Cr PI (54 kDa) is described. It was expressed as a GST-tag fusion protein in Escherichia coli, strain BL21 (DE3). Expression of recombinant Cr PI (rCr PI), denaturation/renaturation of the inclusion bodies and the effects of protein and L-arginine con...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607782110266
更新日期:2007-01-01 00:00:00
abstract::Calreticulin is a soluble endoplasmic reticulum chaperone, which has a relatively low melting point due to its remarkable structure with a relatively high content of flexible structural elements. Using far ultraviolet circular dichroism (CD) spectroscopy and a fluorescent dye binding thermal shift assay, we have inves...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320050009
更新日期:2013-05-01 00:00:00