Abstract:
:Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of selected Gram-negative bacteria but the lack of activity against Gram-positive bacteria and the very low hemolytic activity is probably a consequence of the weak amphipathicity of the peptide in its alpha-helical conformation.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Conlon JM,Al-Ghaferi N,Abraham B,Sonnevend A,King JD,Nielsen PFdoi
10.2174/092986606775974410subject
Has Abstractpub_date
2006-01-01 00:00:00pages
411-5issue
4eissn
0929-8665issn
1875-5305journal_volume
13pub_type
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