Purification and properties of laticeptin, an antimicrobial peptide from skin secretions of the South American frog Leptodactylus laticeps.

Abstract:

:Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of selected Gram-negative bacteria but the lack of activity against Gram-positive bacteria and the very low hemolytic activity is probably a consequence of the weak amphipathicity of the peptide in its alpha-helical conformation.

journal_name

Protein Pept Lett

authors

Conlon JM,Al-Ghaferi N,Abraham B,Sonnevend A,King JD,Nielsen PF

doi

10.2174/092986606775974410

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

411-5

issue

4

eissn

0929-8665

issn

1875-5305

journal_volume

13

pub_type

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