Abstract:
:Background. Obesity is a major health problem in both developed and emerging countries. Obesity is a complex disease whose etiology involves genetic factors in strong interplay with environmental determinants and lifestyle. The discovery of genetic factors and biological pathways underlying human obesity is hampered by the difficulty in controlling the genetic background of human cohorts. Animal models are then necessary to further dissect the genetics of obesity. Pig has emerged as one of the most attractive models, because of the similarity with humans in the mechanisms regulating the fat deposition. Results. We collected the genes related to obesity in humans and to fat deposition traits in pig. We localized them on both human and pig genomes, building a map useful to interpret comparative studies on obesity. We characterized the collected genes structurally and functionally with BAR+ and mapped them on KEGG pathways and on STRING protein interaction network. Conclusions. The collected set consists of 361 obesity related genes in human and pig genomes. All genes were mapped on the human genome, and 54 could not be localized on the pig genome (release 2012). Only for 3 human genes there is no counterpart in pig, confirming that this animal is a good model for human obesity studies. Obesity related genes are mostly involved in regulation and signaling processes/pathways and relevant connection emerges between obesity-related genes and diseases such as cancer and infectious diseases.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Martelli PL,Fontanesi L,Piovesan D,Fariselli P,Casadio Rdoi
10.2174/09298665113209990053subject
Has Abstractpub_date
2014-01-01 00:00:00pages
840-6issue
8eissn
0929-8665issn
1875-5305pii
PPL-EPUB-53867journal_volume
21pub_type
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journal_title:Protein and peptide letters
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journal_title:Protein and peptide letters
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journal_title:Protein and peptide letters
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journal_title:Protein and peptide letters
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journal_title:Protein and peptide letters
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更新日期:2013-02-01 00:00:00
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journal_title:Protein and peptide letters
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journal_title:Protein and peptide letters
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更新日期:2009-01-01 00:00:00
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