Misfolded proteins and human diseases.

Abstract:

:Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better understanding of the processes that lead to these misfolded structures. Further progress in the field of how soluble proteins begin to misfold and how resultant oligomers begin dysfunction offers exciting prospects for specific molecular intervention.

journal_name

Protein Pept Lett

authors

Nayeem MS,Khan RH

doi

10.2174/0929866043406409

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

593-600

issue

6

eissn

0929-8665

issn

1875-5305

journal_volume

11

pub_type

杂志文章,评审
  • Conjugation of resveratrol with RGD and KGD derivatives.

    abstract::The reaction between Arg-Gly-Asp (RGD) and Lys-Gly-Asp (KGD) derivatives with 3,4',5-trihydroxy-trans-stilbene (resveratrol) was investigated. Knowing that resveratrol, RGD as well as KGD analogues inhibit human platelet aggregation in vitro, it was tempting for us to examine whether their coupling products present en...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986607782541141

    authors: Koutsas C,Sarigiannis Y,Stavropoulos G,Liakopoulou-Kyriakides M

    更新日期:2007-01-01 00:00:00

  • Development and Characterization of Polymeric Peptides for Antibody Tagging of Bacterial Targets.

    abstract:BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866527666200427212940

    authors: Climacosa FMM,King RAN,Santos BMM,Caoili SEC

    更新日期:2020-01-01 00:00:00

  • Proteome analysis of rice root plasma membrane and detection of cold stress responsive proteins.

    abstract::To investigate the function of plant plasma membrane, proteins of rice plasma membrane were analyzed and the proteins changed by cold stress were identified. Plasma membrane proteins were purified with an aqueous two-phase partitioning method from root of rice seedlings, and activity of specific H(+)-ATPase localized ...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986609788490140

    authors: Hashimoto M,Toorchi M,Matsushita K,Iwasaki Y,Komatsu S

    更新日期:2009-01-01 00:00:00

  • Incorporating secondary features into the general form of Chou's PseAAC for predicting protein structural class.

    abstract::Protein structure information is very useful for the confirmation of protein function. The protein structural class can provide information for protein 3D structure analysis, causing the conformation of the protein overall folding type plays a significant part in molecular biology. In this paper, we focus on the predi...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986612803217051

    authors: Liao B,Xiang Q,Li D

    更新日期:2012-11-01 00:00:00

  • Preparation and characterization of a novel recombinant human parathyroid hormone (1-34) analog (Gly1-Gln26-rhPTH(1-34)) with enhanced biological activity.

    abstract::A recombinant human parathyroid hormone (rhPTH) fragment (Gly1-Gln26-rhPTH(1-34)) which contains two amino acids substitutions (Gly1 and Gln26) was acquired through Escherichia coli expression system using a soluble fusion protein strategy. The soluble fusion protein MBP-Gly1-Gln26-rhPTH(1-34) was harvested after puri...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986608785203773

    authors: Xu XC,Zhong SD,Kai F,Li LR,Liu C,Liu B,Bao JK

    更新日期:2008-01-01 00:00:00

  • Irbesartan inhibits albumin-elicited proximal tubular cell apoptosis and injury in vitro.

    abstract::There is accumulating evidence that proteinuria is not merely a biomarker for the progression of chronic kidney disease (CKD), but also a mediator of this devastating disorder. Indeed, albumin, one of the major components found in proteinuria, causes proinflammatory and profibrotic changes in cultured proximal tubular...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986610789909430

    authors: Matsui T,Yamagishi S,Ueda S,Fukami K,Okuda S

    更新日期:2010-01-01 00:00:00

  • Autoantibody reaction to myelin basic protein by plasma parvovirus B19 IgG in MS patients.

    abstract::The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, a competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986606775101715

    authors: Thomas G,Rael L,Shimonkevitz R,Melamed I,Bar-Or D

    更新日期:2006-01-01 00:00:00

  • Biochemical characterization of a new maize (Zea mays L.) peptide growth factor.

    abstract::Coordination of cell growth and cell division is very important for living organisms in order for these to develop harmonically. The present research is concerned with the purification and characterization of a new peptide hormone, namely ZmIGF (Zea mays insulin-like growth factor), which regulates growth and cell div...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986611794328636

    authors: Rodríguez-López CD,Rodríguez-Romero A,Aguilar R,de Jiménez ES

    更新日期:2011-01-01 00:00:00

  • Construction of a tailor-made L (2S,3S)-butanediol dehydrogenase by exchanging domains between native structural analogs.

    abstract::The development of a stable L-BDH chimera was attempted by exchanging whole domains between two native structural analogs, L-BDH and meso-BDH, because the S-configuration specificity of L-BDH is valuable from the standpoint of its application but its activity is unstable, whereas meso-BDH is stable. The domain chimera...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986611795713970

    authors: Shimegi T,Takusagawa Y,Ohtsuki T,Noda S,Kurisu G,Kusunoki M,Ui S

    更新日期:2011-08-01 00:00:00

  • Logical Analysis of Regulation of Interleukin-12 Expression Pathway Regulation During HCV Infection.

    abstract::Hepatitis C virus (HCV) triggers coordinated innate and adaptive response in host cell. HCV genome and proteins of the replicating virus are recognized as non-self-antigens by host cell to activate Toll Like Receptors (TLRs). Activated TLRs ultimately express cytokines, which can clear virus either by activating inter...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866523666160419150136

    authors: Farooqi ZU,Tareen SH,Ahmed J,Zaidi NU

    更新日期:2016-01-01 00:00:00

  • Modification of the N-Terminus of a Calcium Carbonate Precipitating Peptide Affects Calcium Carbonate Mineralization.

    abstract:BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866525666171221114658

    authors: Usui K,Yokota SI,Ozaki M,Sakashita S,Imai T,Tomizaki KY

    更新日期:2018-01-01 00:00:00

  • Proteinase K-resistant aggregates of recombinant prion protein PrP-(23-98) are toxic to cultured cells.

    abstract::Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur. ...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986609787049475

    authors: Shiraishi N,Inai Y,Ihara Y

    更新日期:2009-01-01 00:00:00

  • Peptoid analogues of anoplin show antibacterial activity.

    abstract::We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (H-GLLKXIKTLL-NH(2)). The most active compounds showed MIC-values of 12.5 and 25 microM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 microM and 11 microM against E. ...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986609789055421

    authors: Meinike K,Hansen PR

    更新日期:2009-01-01 00:00:00

  • Structural, Functional and Evolutionary Aspects of Seed Globulins.

    abstract::Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology ...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章,评审

    doi:10.2174/0929866523666161220112641

    authors: Kesari P,Neetu,Sharma A,Katiki M,Kumar P,Gurjar BR,Tomar S,Sharma AK,Kumar P

    更新日期:2017-01-01 00:00:00

  • Kinetic and structural studies on the interactions of heparin and proteins of human seminal plasma using surface plasmon resonance.

    abstract::Heparin is naturally occurring polysaccharides which interacts with seminal plasma proteins and regulate multiple steps in fertilization process. Qualitative and quantitative information regarding the affinity for heparin-seminal plasma proteins interactions is not generally well documented and there are no reports of...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986612801619525

    authors: Kumar V,Yadav VK,Hassan MI,Singh AK,Dey S,Singh S,Singh TP,Yadav S

    更新日期:2012-08-01 00:00:00

  • Chemical and thermal unfolding of calreticulin.

    abstract::Calreticulin is a soluble endoplasmic reticulum chaperone, which has a relatively low melting point due to its remarkable structure with a relatively high content of flexible structural elements. Using far ultraviolet circular dichroism (CD) spectroscopy and a fluorescent dye binding thermal shift assay, we have inves...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866511320050009

    authors: Duus K,Larsen N,Tran TA,Güven E,Skov LK,Jespersgaard C,Gajhede M,Houen G

    更新日期:2013-05-01 00:00:00

  • Synthesis of N-succinyl-L,L-diaminopimelic acid mimetics via selective protection.

    abstract::The search for potential inhibitors that target so far unexplored bacterial enzyme mono-N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) has stimulated a development of methodology for quick and efficient preparation of mono-N-acylated 2,6-diaminopimelic acid (DAP) derivatives bearing the different carboxyl gro...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986610790780387

    authors: Vanek V,Pícha J,Budesínský M,Sanda M,Jirácek J,Holz RC,Hlavácek J

    更新日期:2010-03-01 00:00:00

  • Evidences of monomer, dimer and trimer of recombinant human cyclophilin A.

    abstract::Cyclophilin A (CyPA) is a cytosolic receptor of immunosuppressive drug cyclosporin A (CsA) which possesses peptidyl-prodyl cis/trans isomerase (PPIase) activity. The recombinant human CyPA (rhCyPA) gene has been expressed in E. coli M15. Purification was performed using salting-out, as well as Sephacryl S-100 and DEAE...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986611797642670

    authors: Zhang XC,Wang WD,Wang JS,Pan JC,Zou GL

    更新日期:2011-12-01 00:00:00

  • Brown recluse spider venom: proteomic analysis and proposal of a putative mechanism of action.

    abstract::Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986609788923383

    authors: dos Santos LD,Dias NB,Roberto J,Pinto AS,Palma MS

    更新日期:2009-01-01 00:00:00

  • The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).

    abstract::Ewing's Sarcoma transcript-2 (EAT2) also known as SH2D1B is involved in regulation of signalling lymphocytic activation molecule (SLAM) family receptor functions. Cytoplasmic tails of SLAM family receptors contain tyrosine residues which mediate the downstream signal transduction through their phosphorylation. EAT2, c...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866523666160831162239

    authors: Taha M,Nezerwa E,Nam HJ

    更新日期:2016-01-01 00:00:00

  • Solubility improvement of an anthrax toxin peptide inhibitor by rational amino acid randomization.

    abstract::We previously described a potent anthrax toxin inhibitor, based on a phage-library-selected peptide sequence, synthesized as a tetra-branched molecule on a lysine core and further modified for improvement of activity [Pini et al., Biochem. J., 2006, 395, 157]. This branched peptide had very low solubility because of s...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986608784966958

    authors: Pini A,Brunetti J,Falciani C,Fabbrini M,Bracci L

    更新日期:2008-01-01 00:00:00

  • Structural and dynamic properties of incomplete immunoglobulin-like fold domains.

    abstract::The immunoglobulin fold (Ig-fold) is a widespread structural motif that is detected in a variety of proteins involved in diversified biological processes. The Ig-fold contains 70-110 residues that are assembled in a characteristic sandwich-like structure formed by two facing β-sheets each made of antiparallel β-strand...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章,评审

    doi:10.2174/092986612802762732

    authors: Berisio R,Ciccarelli L,Squeglia F,De Simone A,Vitagliano L

    更新日期:2012-10-01 00:00:00

  • Precursor mass dependent filtering of mass spectra for proteomics analysis.

    abstract::Identification and elimination of noise peaks in mass spectra from large proteomics data streams simultaneously improves the accuracy of peptide identification and significantly decreases the size of the data. There are a number of peak filtering strategies that can achieve this goal. Here we present a simple algorith...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/09298665113209990065

    authors: Reiz B,Myers MP,Pongor S,Kertesz-Farkas A

    更新日期:2014-01-01 00:00:00

  • Structure formation in short designed peptides probed by proteolytic cleavage.

    abstract::The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986606776819501

    authors: Saikumari YK,Ravindra G,Balaram P

    更新日期:2006-01-01 00:00:00

  • Histatins in non-human primates: gene variations and functional effects.

    abstract::Human histatins are histidine-rich, low molecular weight salivary proteins that contribute to the immune system of the oral cavity. In this work, nucleotide sequences of the HIS1 (coding for histatin 1) and HIS2 (coding for histatin 3) genes, homologous to the human ones, have been sequenced and analysed in five prima...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986610791306715

    authors: Padovan L,Segat L,Pontillo A,Antcheva N,Tossi A,Crovella S

    更新日期:2010-07-01 00:00:00

  • Protein structure classification using geometric invariants and dynamic programming.

    abstract::Classification of newly determined protein structures is important in understanding their function and mechanism of action. Currently available methods employ a global structure alignment strategy and are computationally expensive. We propose a two-step methodology with a quick screen to significantly reduce the numbe...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986607781483877

    authors: Dalal A,Deshmukh S,Wangika PP

    更新日期:2007-01-01 00:00:00

  • Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.

    abstract:BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866526666190405124353

    authors: Francisco CC,Luis CJ,Marina EJ,Javier CF,Alexis LA,Del Carmen SH,Alfredo RI

    更新日期:2019-01-01 00:00:00

  • Human Hsp70/Hsp90 organizing protein (Hop) D456G is a mixture of monomeric and dimeric species.

    abstract::Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986610790963708

    authors: Gonçalves DC,Gava LM,Ramos CH

    更新日期:2010-04-01 00:00:00

  • Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis.

    abstract::Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthe...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/0929866523666160920095131

    authors: Luo HD,Jin MY,Wu H,Jiang H

    更新日期:2016-01-01 00:00:00

  • Alternative nucleophilic residues in intein catalysis of protein splicing.

    abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...

    journal_title:Protein and peptide letters

    pub_type: 杂志文章

    doi:10.2174/092986611797642760

    authors: Qi X,Wang J,Meng Q,Liu XQ

    更新日期:2011-12-01 00:00:00