Optimization of Protein and Peptide Drugs Based on the Mechanisms of Kidney Clearance.

abstract：BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...

journal_title：Protein and peptide letters

authors： Chukhontseva KN,Salnikov VV,Morenkov OS,Kostrov SV,Demidyuk IV

更新日期：2019-01-01 00:00:00

abstract：:Endonuclease tRNase Z catalyzes the generation of the mature 3' end of tRNA precursors through specific endonucleolytic cleavage. The enzyme has been characterized from organisms representative of all domains of life as well as from organelles, and the crystal structure of three bacterial enzymes has been determined. ...

journal_title：Protein and peptide letters

authors： Ceballos M,Vioque A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:CsaA is among the few chaperones which are present in both bacteria and archaea, but absent in eukaryotes. There are no reports on interactome analysis of CsaA from archaea, till date. Identification of binding partners of CsaA might be helpful in understanding CsaA-associated processes in Picrophilus torrid...

journal_title：Protein and peptide letters

authors： Singhal N,Sharma A,Aswal M,Singh N,Kumar M,Goel M

更新日期：2020-11-26 00:00:00

abstract：:Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...

journal_title：Protein and peptide letters

authors： Yu DY,Qiao N,Liu P,Wei Q

更新日期：2009-01-01 00:00:00

abstract：:Src is a non-receptor protein tyrosine kinase ubiquitously expressed in animals. It is involved in various cellular processes, including the innate immune response in mammals. However, less is known about the function of insect Src. Here we presented a homologue of Src in silkworm (Bombyx mori), named as BmSrc by phyl...

journal_title：Protein and peptide letters

authors： Li X,Hua X,Song L,Xia Q,Wang F

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Laminin, a member of the Extracellular Matrix (ECM), is a glycoprotein that is used as a factor that affects cell adhesion, proliferation, survival, and differentiation. Of these, five globular domains (LG domains) of the alpha chain play an important role in influencing the cell by binding to the integrin. ...

journal_title：Protein and peptide letters

authors： Kim JE,Seo HJ,Lee S,Jang JH

更新日期：2019-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) represent a large and ubiquitous group of peptides. The current crisis in antibiotic therapy has led to an intensified search for new antimicrobial agents. In this regard, scorpion venom constitutes a rich source of biologically active peptides including AMPs. In the present study, the pu...

journal_title：Protein and peptide letters

authors： Dueñas-Cuellar RA,Kushmerick C,Naves LA,Batista IF,Guerrero-Vargas JA,Pires OR Jr,Fontes W,Castro MS

更新日期：2015-01-01 00:00:00

abstract：:Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...

journal_title：Protein and peptide letters

authors： Wang X,Wang D,Zhao J,Qu M,Zhou X,He H,He R

更新日期：2006-01-01 00:00:00

abstract：:A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformat...

journal_title：Protein and peptide letters

authors： Eldeeb MA,Ragheb MA,Esmaili M,Hussein F

更新日期：2020-01-01 00:00:00

abstract：:Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity o...

journal_title：Protein and peptide letters

authors： Zhang HT,Li HC,Li ZW,Guo CH,Chen YJ

更新日期：2011-06-15 00:00:00

abstract：:The mutation, conferring streptomycin and deoxyglucose resistance on cells, had profound effect on the kinetic and thermodynamic parameters inferring thermostabilization of beta-glucosidase from mutant 51 SM(r) of Cellulomonas biazotea. Free energy of activation for substrate binding, enthalpy and entropy of activatio...

journal_title：Protein and peptide letters

authors： Rajoka MI,Durrani IS,Khalid AM

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...

journal_title：Protein and peptide letters

authors： Khan AZ,Shahid A,Cheng H,Mahboob S,Al-Ghanim KA,Bilal M,Liang F,Nawaz MZ

更新日期：2018-01-01 00:00:00

abstract：:Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...

journal_title：Protein and peptide letters

authors： Xu H,Liu WY

更新日期：2003-10-01 00:00:00

abstract：:F(0)F(1)-ATPase is a rotary molecular motor. It is well known that the rotary torque is generated by ATP hydrolysis in F(1) but little is known about how it produces the proton-motive force (PMF) in F(0). Here a cross-linking approach was used to estimate the rotary torque produced by PMF. Three mutant E. coli strains...

journal_title：Protein and peptide letters

authors： Liu X,Cui Y,Chen C,Lai B,Yue J,Zhang Z

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Recently, the small molecule that inhibits the human copper-trafficking proteins Atox1 and CCS was reported, which suggested that small molecule has an effect on the copper regulation system in the cell. The copper chaperones CopC is regarded as a redox switch and possess barrel structure, thus the interacti...

journal_title：Protein and peptide letters

authors： Song Z,Liu J,Yuan W,Bai Z,Gao N

更新日期：2020-01-01 00:00:00

abstract：:We report a new prohormone convertase gene of insect origin, Trichoplusia ni furin, which was cloned from BTI-Tn-5B-4 (Tn5) insect cells. We constructed a truncated mutant that lacked Cys-rich repeated segments. Using baculovirus expression system and standard enzymatic assay, we obtained recombinant Tn furin and eval...

journal_title：Protein and peptide letters

authors： Wang L,Xu D,Qian M,Yang G,Wu X

更新日期：2006-01-01 00:00:00

abstract：:We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (H-GLLKXIKTLL-NH(2)). The most active compounds showed MIC-values of 12.5 and 25 microM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 microM and 11 microM against E. ...

journal_title：Protein and peptide letters

authors： Meinike K,Hansen PR

更新日期：2009-01-01 00:00:00

abstract：:In 2008 cancer was identified by the World Health Organization (WHO) as one of four threats to human health and development. Since the early published reports of the first chemotherapeutic, mustine, in 1946, the anti-cancer drug and development industry has grown into a multi-billion dollar business enterprise. Worldw...

journal_title：Protein and peptide letters

authors： Li Q,Yi L,Marek P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Peptide: N-glycanase is a deglycosylation enzyme releasing N-glycan from glycoproteins. Although glycan specificity analysis of this enzyme has been reported, recognition requirements for the peptide sequence have not been precisely elucidated. OBJECTIVE:In this study, we carried out peptide specificity ana...

journal_title：Protein and peptide letters

authors： Kuribara T,Ishihara T,Kudo T,Hirano M,Totani K

更新日期：2017-01-01 00:00:00

abstract：:In this paper(1) we present a novel framework for protein secondary structure prediction. In this prediction framework, firstly we propose a novel parameterized semi-probability profile, which combines single sequence with evolutionary information effectively. Secondly, different semi-probability profiles are respecti...

journal_title：Protein and peptide letters

authors： Huang DS,Huang X

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer. OBJECTIVE:This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical...

journal_title：Protein and peptide letters

authors： de Carvalho Fraga CA,Farias LC,Jones KM,Batista de Paula AM,Guimaraes ALS

更新日期：2017-11-17 00:00:00

abstract：:For biophysical studies using heteronuclear NMR analysis of amyloid beta peptide, construction of an efficient and high yield expression system of uniformly isotopic labeled amyloid beta peptide is desirable. Here we succeeded in obtaining (15)N-labeled amyloid beta 1-40 expressed by attachment to hen egg white lysozy...

journal_title：Protein and peptide letters

authors： Nagata-Uchiyama M,Yaguchi M,Hirano Y,Ueda T

更新日期：2007-01-01 00:00:00

abstract：:The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...

journal_title：Protein and peptide letters

authors： Joshi RR,Manda C

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to design and develop stable nanoemulsion formulations containing IFN-γ to probe their use as an immunomodulating agent. The nanoemulsions comprising distilled water, triglycerides of capric acid/caprylic, sobitan-oleate (SP), polysorbate 80 (TW) and propylene glycol (PG) were prepared throug...

journal_title：Protein and peptide letters

authors： Ribeiro EB,Honorio-França AC,França EL,Soler MA

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Wheat germ, one of the byproducts of flour milling, contains abundant physiologically active components. Globulins in wheat germ are a class of high-quality functional proteins and have received widespread attention. However, the composition of wheat germ globulin（ WGG）and the structure of the typical protei...

journal_title：Protein and peptide letters

authors： Ji XG,Huang JH,Hui M,Zhang YQ,Zhao Y

更新日期：2018-02-08 00:00:00

abstract：:Proteases have been used not only for proteolysis but also in organic solvent-assisted religation processes. Here, we demonstrated the effect of salts on peptide bond resynthesis in Glutathione-S-transferase (GST) and have found it to be in the purview of the Hofmeister phenomena. Our results show that the efficiency ...

journal_title：Protein and peptide letters

authors： Kishan KV,Sharma A

更新日期：2010-01-01 00:00:00

abstract：:Alpha-gliadins isolated by carboxymethylcellulose chromatography contain noncovalently bound glucose probably due to contaminating proteoglycans and to material shed from the column. Traces of carbohydrate remain strongly bound to alpha-gliadins even after harsh denaturation, but our results indicate alpha-gliadins ar...

journal_title：Protein and peptide letters

authors： Turner JB,Garner GV,Gordon DB,Brookes SJ,Smith CA

更新日期：2002-02-01 00:00:00

abstract：:AB204 is an Activin/BMP2 chimera, which has been found to exhibit a higher activity than Bone Morphogenetic Protein 2 (BMP2) in osteogenic activity. To prepare AB204 for its preclinical studies, AB204 has been characterized in various formulation buffers. We observed that AB204 purified by ion-exchange chromatography ...

journal_title：Protein and peptide letters

authors： Ahn C,Maslennikov I,Choi JY,Oh H,Cheong C,Choe S

更新日期：2014-05-01 00:00:00

abstract：:DrTI was effective against trypsin-like enzymes from A. kuehniella and C. cephalonica, however an artificial diet was insufficient to affect the survival and body weight of either insect. The inhibitor stimulated chymotrypsin-like enzymes and probably induced the synthesis of enzymes insensitive to TLCK in neonate lar...

journal_title：Protein and peptide letters

authors： Macedo ML,Pando SC,Chevreuil LR,Marangoni S

更新日期：2009-01-01 00:00:00

abstract：:Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Nucleotide-sugars, lipid phosphate sugars and phosphate sugars can act as activated donor molecules while acceptor substrate...

journal_title：Protein and peptide letters

authors： Gomez-Casati DF,Martín M,Busi MV

更新日期：2013-08-01 00:00:00