Abstract:
:A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformations in proteins and often help them to regain their correct conformation. However, if repair is not an option, the abnormal protein is selectively degraded to prevent its oligomerization into toxic multimeric complexes. Autophagiclysosomal system and the ubiquitin-proteasome system mediate the targeted degradation of the aberrant protein fragments. Despite the increasing understanding of the molecular counteracting responses toward the accumulation of dysfunctional misfolded proteins, the molecular links between the upstream physiological inputs and the clearance of abnormal misfolded proteins is relatively poorly understood. Recent work has demonstrated that certain physiological states such as vigorous exercise and fasting may enhance the ability of mammalian cells to clear misfolded, toxic and aberrant protein fragments. These findings unveil a novel mechanism that activates the cells' protein-disposal machinery, facilitating the adaptation process of cellular proteome to fluctuations in cellular demands and alterations of environmental cues. Herein, we briefly discuss the molecular interconnection between certain physiological cues and proteasomal degradation pathway in the context of these interesting findings and highlight some of the future prospects.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Eldeeb MA,Ragheb MA,Esmaili M,Hussein Fdoi
10.2174/0929866526666191026111951subject
Has Abstractpub_date
2020-01-01 00:00:00pages
251-255issue
3eissn
0929-8665issn
1875-5305pii
PPL-EPUB-101925journal_volume
27pub_type
杂志文章abstract::Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190410124642
更新日期:2020-01-01 00:00:00
abstract::Background. Obesity is a major health problem in both developed and emerging countries. Obesity is a complex disease whose etiology involves genetic factors in strong interplay with environmental determinants and lifestyle. The discovery of genetic factors and biological pathways underlying human obesity is hampered b...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113209990053
更新日期:2014-01-01 00:00:00
abstract::The studies presented here explore antimicrobial peptide preferential binding behavior for a target pathogen, Escherichia coli O157:H7. A modified immunoassay and surface plasmon resonance were employed to evaluate immobilized peptide binding of whole bacterial cells. The knowledge gained may guide the rational design...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608786071049
更新日期:2008-01-01 00:00:00
abstract::The high technical standard of current peptide chemistry, which has evolved over the past three decades, has profoundly facilitated the investigation of proteins and their interactions with other molecules at the level of individual amino acids. Using currently available peptide synthesis methods, sequentially continu...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866043406931
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200916142305
更新日期:2020-09-16 00:00:00
abstract::A new coding sequence of the procarboxypeptidase B gene was obtained from SD rat fresh pancreas by RT-PCR and highly expressed in Escherichia coli in inclusion bodies. The folded procarboxypeptidase B was subjected to trypsin enzymatic cleavage to produce active carboxypeptidase B, subsequently, carboxypeptidase B was...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478627
更新日期:2003-12-01 00:00:00
abstract::The formation of amyloid-like fibrils was studied by using the well-known serine protease trypsin as a model protein in the presence of ethanol as organic solvent. Trypsin forms amyloid-like fibrils in aqueous ethanol at pH = 7.0. The dye Congo red (CR) was used to detect the presence of amyloid-like fibrils in the sa...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666151002154324
更新日期:2015-01-01 00:00:00
abstract::We report a new prohormone convertase gene of insect origin, Trichoplusia ni furin, which was cloned from BTI-Tn-5B-4 (Tn5) insect cells. We constructed a truncated mutant that lacked Cys-rich repeated segments. Using baculovirus expression system and standard enzymatic assay, we obtained recombinant Tn furin and eval...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775101553
更新日期:2006-01-01 00:00:00
abstract::Eukaryotic translation initiation factor 5A (eIF-5A) is universally found in all eukaryotic cells. It is the only protein in nature known to contain the unusual amino acid hypusine, a post-translationally modified lysine. Recombinant human eIF-5A was crystallized by the hanging-drop vapor diffusion method. Crystals we...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866054696091
更新日期:2005-10-01 00:00:00
abstract::Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the d...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986606777790502
更新日期:2006-01-01 00:00:00
abstract::Human histatins are histidine-rich, low molecular weight salivary proteins that contribute to the immune system of the oral cavity. In this work, nucleotide sequences of the HIS1 (coding for histatin 1) and HIS2 (coding for histatin 3) genes, homologous to the human ones, have been sequenced and analysed in five prima...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791306715
更新日期:2010-07-01 00:00:00
abstract::We report that the plant oncoprotein RolA from Agrobacterium rhizogenes acts to stabilize beta-glucoronidase (Gus) when the two proteins are expressed as a fusion protein in transformed tobacco. The observed 50-fold increase of Gus activity was shown to be related to protein accumulation, with no significant changes i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478951
更新日期:2003-06-01 00:00:00
abstract::The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320030016
更新日期:2013-03-01 00:00:00
abstract::Glycation, a non-enzymatic reaction between glucose and protein is the primary cause of diabetic complications. Albumin, the most abundant plasma protein undergoes glycation both in vivo and in vitro. The influence of albumin on glycation of less abundant proteins has not been addressed. For the first time, we show th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785133690
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Microbe-Binding Peptides (MBPs) are currently being investigated to address the problem of antimicrobial resistance. Strategies enhancing their antimicrobial activity have been developed, including peptide dimerization. Here, we present an alternative approach based on peptide polymerization, yielding hapten...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200427212940
更新日期:2020-01-01 00:00:00
abstract::Influenza viruses cause a significant level of morbidity and mortality in the population every year. Their resistance to current anti-influenza drugs increases the difficulty of flu treatment. Thus, development of new anti-influenza drugs is necessary in regards of prevent the tragedy of influenza pandemic. The Polyme...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611796378675
更新日期:2011-10-01 00:00:00
abstract::In this article we review the current status of our understanding of membrane mediated interactions from theory and experiment. Phenomenological mean field and molecular models will be discussed and compared to recent experimental results from dynamical neutron scattering and atomic force microscopy. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986611794653941
更新日期:2011-04-01 00:00:00
abstract::Free radicals induce protein modifications, often associated to many biological phenomena. This mini-review overviews the approaches we have used to elucidate the radical-induced damages on sulfur-containing enzymes, such as ribonuclease and lysozyme, and the possible post-translational mechanism of the damage to anot...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986607781483840
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Malignant tumor is still one of the important diseases worldwide, cytotoxic CD8+ T lymphocytes (CTLs) play an important role in killing tumor cells. OBJECTIVE:To enhance the immune response of our previously identified HLA-A2-restricted CTL epitopes, we designed a multiepitope YL66. METHOD:The fusion prote...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866524666170419152700
更新日期:2017-01-01 00:00:00
abstract::Nucleobindin-2 is a 420 amino acid EF-hand Ca²⁺ binding protein that can be further processed to generate an 82 amino terminal peptide termed Nesfatin-1. To examine the function of secreted Nucleobindin-2 in adipocyte differentiation, cultured 3T3-L1 cells were incubated with either 0 or 100 nM of GST, GST-Nucleobindi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612802084546
更新日期:2012-09-01 00:00:00
abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642760
更新日期:2011-12-01 00:00:00
abstract::Protein structure information is very useful for the confirmation of protein function. The protein structural class can provide information for protein 3D structure analysis, causing the conformation of the protein overall folding type plays a significant part in molecular biology. In this paper, we focus on the predi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612803217051
更新日期:2012-11-01 00:00:00
abstract::A novel cellulase was isolated from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius ATCC27009 grown in medium containing carboxymethylcellulose. The enzyme is a glycosylated monomer of 56.2 kDa, relatively thermostable, with optimal pH and temperature of 4.0 and 65 degrees C, respectively. Enzymatic as...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785849209
更新日期:2008-01-01 00:00:00
abstract::The aerotolerance of the lactic - fermentative bacterium Streptococcus thermophilus is mainly based on the key antioxidant function of superoxide dismutase (StSOD). In this work, the comparison of recombinant StSOD (rStSOD) forms obtained from two different initiation triplets indicated that the enzyme from S. thermop...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612799363127
更新日期:2012-03-01 00:00:00
abstract::Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788681724
更新日期:2009-01-01 00:00:00
abstract::The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511009011436
更新日期:2010-11-01 00:00:00
abstract::Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478771
更新日期:2003-10-01 00:00:00
abstract::Ewing's Sarcoma transcript-2 (EAT2) also known as SH2D1B is involved in regulation of signalling lymphocytic activation molecule (SLAM) family receptor functions. Cytoplasmic tails of SLAM family receptors contain tyrosine residues which mediate the downstream signal transduction through their phosphorylation. EAT2, c...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160831162239
更新日期:2016-01-01 00:00:00
abstract::Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986607782541114
更新日期:2007-01-01 00:00:00
abstract::Bacterial ADP-ribosyltransferases (BADPRTs) are extensively contributed to determine the strain-specific virulence state and pathogenesis in human hosts. Understanding molecular evolution and functional diversity of the BADPRTs is an important standpoint to describe the fundamental behind in the vaccine designing for ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320090012
更新日期:2013-09-01 00:00:00