The X-ray Crystallographic Structure of Human EAT2 (SH2D1B).

abstract：:Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. In order to understand the different adhesive mechanisms at the T-cell surface, Schubert randomly selected 19 proteins expressed at the T-cell su...

journal_title：Protein and peptide letters

authors： Li FZ,Gao F

更新日期：2012-08-01 00:00:00

abstract：:Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...

journal_title：Protein and peptide letters

authors： Liao B,Fu X,Cai L,Chen H

更新日期：2014-07-01 00:00:00

abstract：:The interaction of nickel tetra sulfunated phthalocyanine( NiTSPc) with human serum albumin (HSA), in 20 mM phosphate buffer pH 7.4 was investigated using advanced techniques including fluorescence, synchronous fluorescence, Fourier transform infrared (FT-IR), circular dichroism (CD) spectroscopy and molecular docking...

journal_title：Protein and peptide letters

authors： Dezhampanah H,Firouzi R,Hasani L

更新日期：2016-01-01 00:00:00

abstract：:Comparison between the BAD complexes indicated that BAD all docks a hydrophobic surface of PKAc regardless of its phosphorylation. PKAc may prevent Bcl-xL from rebinding to BAD by phosphorylating human BAD at Ser118; whereas human BAD is phosphorylated on Ser75 in a BAD-Bcl-xL complex, resulting in the dissociation of...

journal_title：Protein and peptide letters

authors： Yang J

更新日期：2010-02-01 00:00:00

abstract：:Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cos...

journal_title：Protein and peptide letters

authors： Srinivas S,Prakash V

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:NMAAP1 plays a role in regulating macrophage differentiation to the M1 type and exerting antitumoral functions. It is not clear what role and mechanism NMAAP1 does play in the reversal of macrophages from M1 to M2. METHODS:We detected the typing of macrophages with high or low expression of NMAAP1 by QPCR a...

journal_title：Protein and peptide letters

authors： Liu Q,Zhu P,Liu S,Tang M,Wang Y,Tian Y,Jin Z,Li D,Yan D

更新日期：2019-01-01 00:00:00

abstract：:Although macromolecular crystallography is a widely supported technique at synchrotron radiation facilities throughout the world, there are, in comparison, only very few beamlines dedicated to small-molecule crystallography. This limited provision is despite the increasing demand for beamtime from the chemical crystal...

journal_title：Protein and peptide letters

authors： Barnett SA,Nowell H,Warren MR,Wilcox A,Allan DR

更新日期：2016-01-01 00:00:00

abstract：:A missense mutation of Aspartic to Asparagine acid in 113 position of liver-targeting peptide CSP I-plus modified rEndostatin (rES-CSP) happened unexpectedly results in the changes of protein secondary structure and a reduced bioactivity. With the aim to clarify the structure-function relationships featuring the fuse ...

journal_title：Protein and peptide letters

authors： Bao D,Jin X,Ma Y,Zhu J

更新日期：2015-01-01 00:00:00

abstract：:Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthe...

journal_title：Protein and peptide letters

authors： Luo HD,Jin MY,Wu H,Jiang H

更新日期：2016-01-01 00:00:00

abstract：:Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplas...

journal_title：Protein and peptide letters

authors： Ahmad I,Khan TS,Hoessli DC,Walker-Nasir E,Kaleem A,Shakoori AR,Nasir-ud-Din

更新日期：2008-01-01 00:00:00

abstract：:A recombinant human parathyroid hormone (rhPTH) fragment (Gly1-Gln26-rhPTH(1-34)) which contains two amino acids substitutions (Gly1 and Gln26) was acquired through Escherichia coli expression system using a soluble fusion protein strategy. The soluble fusion protein MBP-Gly1-Gln26-rhPTH(1-34) was harvested after puri...

journal_title：Protein and peptide letters

authors： Xu XC,Zhong SD,Kai F,Li LR,Liu C,Liu B,Bao JK

更新日期：2008-01-01 00:00:00

abstract：:Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and t...

journal_title：Protein and peptide letters

authors： Chen W,Nie F,Ding H

更新日期：2020-01-01 00:00:00

abstract：:Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...

journal_title：Protein and peptide letters

authors： Gonçalves DC,Gava LM,Ramos CH

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...

journal_title：Protein and peptide letters

authors： Chukhontseva KN,Salnikov VV,Morenkov OS,Kostrov SV,Demidyuk IV

更新日期：2019-01-01 00:00:00

abstract：:A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformat...

journal_title：Protein and peptide letters

authors： Eldeeb MA,Ragheb MA,Esmaili M,Hussein F

更新日期：2020-01-01 00:00:00

abstract：:Apelin, an endogenous ligand of the G-protein-coupled receptor APJ, is a novel myokine and may play a key role in regulating energy metabolism. The purpose of the present study was to investigate the effects of hypoxic exposure, exercise, and hypoxic exercise training on the expression of apelin and APJ in skeletal mu...

journal_title：Protein and peptide letters

authors： Ji W,Gong L,Wang J,He H,Zhang Y

更新日期：2017-01-01 00:00:00

abstract：:C-terminal peptide alpha-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the c...

journal_title：Protein and peptide letters

authors： Camarero JA,Mitchell AR

更新日期：2005-11-01 00:00:00

abstract：:With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...

journal_title：Protein and peptide letters

authors： Yang L,Xia JF,Gui J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Chickpea is a widely grown legume in India, Australia, Canada, and Mediterranean regions. Seeds of chickpea are good source of protein for both human and animals. Wild relatives of chickpea (Cicer arietinum) are the potential gene pool for crop improvement; however, very little information is available on th...

journal_title：Protein and peptide letters

authors： Dhar S,Bhattacharjee M,Acharjee S,Baishya D

更新日期：2020-09-10 00:00:00

abstract：:A Surface Plasmon Resonance Imaging (SPRI) sensor has been developed for highly selective determination of cathepsin D (Cat D) or/and E (Cat E). The sensor contains immobilised pepstatin A, which binds aspartyl proteases from solution. Pepstatin A activated with N-Hydroxysuccinimide (NHS) and N-Ethyl-N'-(3-dimethylami...

journal_title：Protein and peptide letters

authors： Gorodkiewicz E,Regulska E

更新日期：2010-09-01 00:00:00

abstract：:Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and acts as hydrideaccepting and hydride-donating coenzymes in energy production. Identification of NAD protein interacting sites can significantly aid in understanding the NAD dependent metabolism and pathways, and it could further...

journal_title：Protein and peptide letters

authors： Wang X,Wang CC,Zhang YQ,Mi G,Zhang J,Li ML

更新日期：2012-05-01 00:00:00

abstract：:The P2 protein (equivalent of L7/L12 in prokaryotes), a member of the ribosomal stalk in eukaryotes, is highly conserved, particularly its C-terminal domain. In order to understand the sequence-structure-function relationships in eukaryotic C-terminal stretches, about which nothing is known at the moment, we have inve...

journal_title：Protein and peptide letters

authors： Mishra P,Rajagopal S,Sharma S,Hosur RV

更新日期：2014-01-01 00:00:00

abstract：:Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...

journal_title：Protein and peptide letters

authors： Wang X,Wang D,Zhao J,Qu M,Zhou X,He H,He R

更新日期：2006-01-01 00:00:00

abstract：:During spermiogenesis, the elongating rat spermatid chromatin undergoes a gradual process of condensation which is initiated in the round spermatids at "step 7" of cytodifferentation in stage VII and extending to elongated spermatids at "step 19" of cytodifferentiation in stage VIII. The mechanism of chromatin condens...

journal_title：Protein and peptide letters

authors： Gill-Sharma MK,Choudhuri J,D'Souza S

更新日期：2011-08-01 00:00:00

abstract：:This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29/L37a, S29/L38, S29/S27 and S29/...

journal_title：Protein and peptide letters

authors： Zhou ZD,Bao L,Liu DG,Li MQ,Ge YZ,Huang YL,Liu WY

更新日期：2003-02-01 00:00:00

abstract：:The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in m...

journal_title：Protein and peptide letters

authors： Fulda S,Linseisen J,Wolfram G,Himmerich S,Gedrich K,Pollmächer T,Himmerich H

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:OPT3s are involved in the transport of Fe from xylem to phloem, in loading Fe into phloem, and in the transmission of shoot-to-root iron signaling. Yet, apart from Arabidopsis, little is known about these transporters'functions in other plant species. OBJECTIVE:OPT3 proteins of several plant species were ch...

journal_title：Protein and peptide letters

authors： Kurt F

更新日期：2020-06-25 00:00:00

abstract：:Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune re...

journal_title：Protein and peptide letters

authors： Hirsch T,Jacobsen F,Steinau HU,Steinstraesser L

更新日期：2008-01-01 00:00:00

abstract：:Human beta-defensin-2 (hBD2) is A small cationic peptide with A broad range of antimicrobial activity. An E. coli cell-free system was employed to express the hBD2 fusion protein by using the hBD2 gene with 14 rare codons. The results showed that the expression level of trxA-hBD2 fusion protein was 0.35 mg/ml, which i...

journal_title：Protein and peptide letters

authors： Chen H,Xu Z,Cen P

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Type VI Secretion System (T6SS) has been found in approximately onequarter of the gram-negative bacterial species, and its structural characteristics appear to slightly differ from species to species. The genes encoding T6SS are designated as type six secretion A-M (tssA-M). The expression of the tss gene cl...

journal_title：Protein and peptide letters

authors： Ok CK,Chang JH

更新日期：2019-01-01 00:00:00