Meta genome-wide network from functional linkages of genes in human gut microbial ecosystems.

Abstract:

:The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the basis of a set of functionally coupled genes regardless of their genome origins when considering the co-evolution properties of genes. By analyzing these coupled genes, we showed some basic properties of HGME significantly associated with each other, and further constructed a protein interaction map of human gut meta-genome to discover some functional modules that may relate with essential metabolic processes. Compared with other studies, our method provides a new idea to extract basic function elements from meta-genome systems and investigate complex microbial environment by associating its biological traits with co-evolutionary fingerprints encoded in it.

journal_name

Protein Pept Lett

authors

Ji Y,Shi Y,Wang C,Dai J,Li Y

doi

10.2174/0929866511320030016

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

371-8

issue

3

eissn

0929-8665

issn

1875-5305

pii

PPL-EPUB-20120515-3

journal_volume

20

pub_type

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