Abstract:
:The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the basis of a set of functionally coupled genes regardless of their genome origins when considering the co-evolution properties of genes. By analyzing these coupled genes, we showed some basic properties of HGME significantly associated with each other, and further constructed a protein interaction map of human gut meta-genome to discover some functional modules that may relate with essential metabolic processes. Compared with other studies, our method provides a new idea to extract basic function elements from meta-genome systems and investigate complex microbial environment by associating its biological traits with co-evolutionary fingerprints encoded in it.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Ji Y,Shi Y,Wang C,Dai J,Li Ydoi
10.2174/0929866511320030016subject
Has Abstractpub_date
2013-03-01 00:00:00pages
371-8issue
3eissn
0929-8665issn
1875-5305pii
PPL-EPUB-20120515-3journal_volume
20pub_type
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