tRNase Z.

abstract：:Rheumatoid arthritis (RA) is a chronic disease with an autoimmunological background. RA is mostly characterized by systemic inflammation and injuries of synovial joints. There is a hypothesis that bacterial infections may be connected with development of the disease. It has been suggested that molecular mimicry betwee...

journal_title：Protein and peptide letters

authors： Konieczna I,Kwinkowski M,Kolesińska B,Kamiński Z,Zarnowiec P,Kaca W

更新日期：2012-11-01 00:00:00

abstract：:After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show th...

journal_title：Protein and peptide letters

authors： Wu G,Yan S

更新日期：2008-01-01 00:00:00

abstract：:We previously described a potent anthrax toxin inhibitor, based on a phage-library-selected peptide sequence, synthesized as a tetra-branched molecule on a lysine core and further modified for improvement of activity [Pini et al., Biochem. J., 2006, 395, 157]. This branched peptide had very low solubility because of s...

journal_title：Protein and peptide letters

authors： Pini A,Brunetti J,Falciani C,Fabbrini M,Bracci L

更新日期：2008-01-01 00:00:00

abstract：:Retro-ACP (74-65) fragment was synthesized on a novel 4% tri-(propylene glycol) glycerolate diacrylate cross-linked polystyrene (PS-TRPGGDA) support. The peptide is grown from the functional site present in the cross-linker, which makes it unique and cost-effective among other styrene based polymer supports. A compara...

journal_title：Protein and peptide letters

authors： Sasikumar PG,Kumar KS,Pillai VN

更新日期：2003-10-01 00:00:00

abstract：:S-adenosyl-l-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 A, b = 86.31 A, and c = 335.6 A. There are four subunits (one tetramer) per as...

journal_title：Protein and peptide letters

authors： Tanaka N,Kusakabe Y,Shiraiwa K,Sakamoto Y,Nakanishi M,Kitade Y,Nakamura KT

更新日期：2004-04-01 00:00:00

abstract：:The high technical standard of current peptide chemistry, which has evolved over the past three decades, has profoundly facilitated the investigation of proteins and their interactions with other molecules at the level of individual amino acids. Using currently available peptide synthesis methods, sequentially continu...

journal_title：Protein and peptide letters

authors： Eichler J

更新日期：2004-08-01 00:00:00

abstract：:The stability of Merrifield linker in Fmoc deprotection process was quantitatively investigated by establishing working curve of two major decomposition components from two resin bound dipeptide models. By sampling reaction solution and analyzing with RP-HPLC, decomposition rate was determined. The results indicated t...

journal_title：Protein and peptide letters

authors： Yang X,Lin H,Lu W,Wang D

更新日期：2013-02-01 00:00:00

abstract：:Heat shock proteins (HSPs) consist of a large group of proteins with negligible expressions under physiological conditions. Their expressions are highly induced under stress conditions and they are ubiquitously expressed in various tissues and organs. HSPs possess chaperone functions, thus facilitating the correct fol...

journal_title：Protein and peptide letters

authors： Lu WJ,Lee NP,Fatima S,Luk JM

更新日期：2009-01-01 00:00:00

abstract：:Catalase is an enzyme that occurs in almost all aerobic organisms. Its main metabolic function is to prevent oxidative damage to tissues induced by hydrogen peroxide which is a strong oxidizing agent. Catalase is very effective in performing this task, since it has the highest turnover rate among all the enzymes. The ...

journal_title：Protein and peptide letters

authors： Seixas FA,da Silva MR,Murakami MT,Tosqui P,Colombo MF

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Paraoxonase (PON; arilesterase, [EC 3.1.8.1]) is an enzyme from the group arilesterases (ARE). This enzyme is capable of hydrolyzing paraoxone which is the active metabolite of parathion, an organic phosphorus insecticide. PON activity was found to be low in individuals prone to development of atherosclerosi...

journal_title：Protein and peptide letters

authors： Yılmaz A,Dilek E

更新日期：2019-01-01 00:00:00

abstract：:Norepinephrine-stimulated skin secretions from the Sante Fe frog Leptodactylus laticeps contained high concentrations of a peptide, termed laticeptin, with the primary structure Gly-Val-Val-Asp-Ile-Leu-Lys-Gly-Ala-Ala-Lys-Asp-Leu-Ala-Gly-His-Leu-Ala-Thr-Lys-Val-Met-Asn-Lys-Leu.NH(2). Laticeptin inhibited the growth of...

journal_title：Protein and peptide letters

authors： Conlon JM,Al-Ghaferi N,Abraham B,Sonnevend A,King JD,Nielsen PF

更新日期：2006-01-01 00:00:00

abstract：:α-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common m...

journal_title：Protein and peptide letters

authors： Ruzza P,Gazziero M,Marchi MD,Massalongo G,Marchiani A,Autiero I,Tessari I,Bubacco L,Calderan A

更新日期：2015-01-01 00:00:00

abstract：:Successful approaches of de novo protein design suggest a great potential to create novel structural folds and to understand natural rules of protein folding. For these purposes, smaller and simpler de novo proteins have been developed. Here, we constructed smaller proteins by removing the terminal sequences from stab...

journal_title：Protein and peptide letters

authors： Okura H,Takahashi T,Mihara H

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...

journal_title：Protein and peptide letters

authors： Li R,Li H,Yang S,Feng X

更新日期：2020-01-01 00:00:00

abstract：:The superoxide anion radical is a highly reactive toxic species produced during the metabolic processes. A number of copper (II) complexes with amino acids and peptides are known to show superoxide dismutase (SOD) like activity. The design and application of synthetic low molecular weight metal complexes as SOD mimics...

journal_title：Protein and peptide letters

authors： Singh RK,Srivastava VC,Singh UP

更新日期：2011-12-01 00:00:00

abstract：:Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. In order to understand the different adhesive mechanisms at the T-cell surface, Schubert randomly selected 19 proteins expressed at the T-cell su...

journal_title：Protein and peptide letters

authors： Li FZ,Gao F

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Breast cancer demands safe adjuvant to overcome the side effects of standard drug tamoxifen. Diet derived bioactive compounds are reported to exhibit modulation of cancer growth leading to cell death. Chickpea is a protein rich edible legume with several bioactive compounds that includes lectin as well. Char...

journal_title：Protein and peptide letters

authors： Gupta N,Bisen PS,Bhagyawant SS

更新日期：2018-01-01 00:00:00

abstract：:Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide syn...

journal_title：Protein and peptide letters

authors： Bayryamov SG,Vassilev NG,Petkov DD

更新日期：2010-07-01 00:00:00

abstract：:Application of complementary B and T cell epitopes in inducing anti-idiotypic and anti-clonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many rese...

journal_title：Protein and peptide letters

authors： Sakarellos-Daitsiotis M,Cung MT,Sakarellos C,El Hilali Z,Kosmopoulou A,Voitharou C

更新日期：2004-08-01 00:00:00

abstract：:Many polyketides show biological activities and have thus been applied in clinics, as food additives, and in agriculture. Type II thioesterases (TEIIs) play an important role in polyketide biosynthesis. Most TEIIs belong to α/β-hydrolase family and usually contain a catalytic triad Ser-His-Asp. In polyketide biosynthe...

journal_title：Protein and peptide letters

authors： Luo HD,Jin MY,Wu H,Jiang H

更新日期：2016-01-01 00:00:00

abstract：:Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage...

journal_title：Protein and peptide letters

authors： dos Santos LD,Dias NB,Roberto J,Pinto AS,Palma MS

更新日期：2009-01-01 00:00:00

abstract：:Identification on protein folding types is always based on the 27-class folds dataset, which was provided by Ding & Dubchak in 2001. But with the avalanche of protein sequences, fold data is also expanding, so it will be the inevitable trend to improve the existing dataset and expand more folding types. In this paper,...

journal_title：Protein and peptide letters

authors： Liu L,Hu XZ,Liu XX,Wang Y,Li SB

更新日期：2012-04-01 00:00:00

abstract：:Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Nucleotide-sugars, lipid phosphate sugars and phosphate sugars can act as activated donor molecules while acceptor substrate...

journal_title：Protein and peptide letters

authors： Gomez-Casati DF,Martín M,Busi MV

更新日期：2013-08-01 00:00:00

abstract：:Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...

journal_title：Protein and peptide letters

authors： Rajendran SR,Ejike CE,Gong M,Hannah W,Udenigwe CC

更新日期：2017-01-01 00:00:00

abstract：:Cationic antimicrobial peptides (AMPs) are among the best studied antimicrobial factors expressed in the respiratory tract. AMPs are released by epithelial cells and immune cells into the airway surface liquid covering the epithelial surfaces of the lung where they act as endogenous antibiotics. Plenty of studies show...

journal_title：Protein and peptide letters

authors： Seiler F,Lepper PM,Bals R,Beisswenger C

更新日期：2014-04-01 00:00:00

abstract：:Prediction of thermophilic and mesophilic protein plays a crucial role in both biochemistry and bioengineering. In this study, a different mode of pseudo amino acid composition (PseAAC) was proposed to formulate the protein samples by integrating the amino acid composition, the physic chemical features, as well as the...

journal_title：Protein and peptide letters

authors： Wang D,Yang L,Fu Z,Xia J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Malignant tumor is still one of the important diseases worldwide, cytotoxic CD8+ T lymphocytes (CTLs) play an important role in killing tumor cells. OBJECTIVE:To enhance the immune response of our previously identified HLA-A2-restricted CTL epitopes, we designed a multiepitope YL66. METHOD:The fusion prote...

journal_title：Protein and peptide letters

authors： Wu Y,Zhai W,Sun M,Zou Z,Zhou X,Li G,Yan Z,Qi Y,Gao Y

更新日期：2017-01-01 00:00:00

abstract：:Current advancements in biological protein discovery utilize bi-partite methods of fluorescence detection where chromophore and scaffold are uncoupled. One such technology, called fluorogen-activating proteins (FAPs), consists of single-chain-variable-fragments (scFvs) selected against small organic molecules (fluorog...

journal_title：Protein and peptide letters

authors： Gallo E,Wienbar S,Snyder AC,Vasilev KV,Armitage BA,Jarvik JW

更新日期：2014-01-01 00:00:00

abstract：:From the extensive analysis, we identified three highly conserved sequence segments in HCV NS5A proteins and one binding motif in human proteins. The binding motif of human proteins often forms a full helix or an extended strand-loop structure, and is in good agreement with the experimental findings of previous studie...

journal_title：Protein and peptide letters

authors： Zhang GZ,Han K

更新日期：2008-01-01 00:00:00

abstract：:Apomyoglobin (apoMb) folds through at least two partially folded forms that are detected both as transient intermediates during folding/unfolding kinetics or as stable intermediates at equilibrium. Here, I summarize the results of recent kinetic studies, which combined with detailed characterizations of equilibrium fo...

journal_title：Protein and peptide letters

authors： Jamin M

更新日期：2005-04-01 00:00:00