Abstract:
BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass for commercial purposes is still in its infancy due to the dearth of the knowledge regarding state-of-the-art sophisticated technologies. OBJECTIVES:The main objective of the study was to review the explosions of innovative strategies that biological sciences have witnessed over the past several years, enabling the scientific community and research-based organizations to scrutinize entire classes of biomolecules from a cell type or whole organism, collectively titled as 'Omics, including genomics, transcriptomics, proteomics and lipidomics. METHODS:An effort has been made to analyze the relative advantages and drawbacks of these technologies by reviewing and consulting the available literature. RESULTS:Nevertheless, these 'Omics strategies have played a key role in the better understanding of the underlying mechanisms of specific gene products, regulatory constraints, metabolic pathways and potential genes and protein targets which might be employed in tailoring microalgae for enhanced productivity. In this critical review, an understanding of recent omics technologies, their potential applications, and limitations for microalgae-based fuel and other commodity chemicals are comprehensively discussed. CONCLUSION:In the scenario of uncertain petro-based reserves, global warming and energy insecurity, the exploration of metabolic potentialities of microalgae using "Omics" are believed to be a green and environmentally-responsive approach that will further expand its industrial and environmental scope.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Khan AZ,Shahid A,Cheng H,Mahboob S,Al-Ghanim KA,Bilal M,Liang F,Nawaz MZdoi
10.2174/0929866525666180122100722subject
Has Abstractpub_date
2018-01-01 00:00:00pages
99-107issue
2eissn
0929-8665issn
1875-5305pii
PPL-EPUB-88085journal_volume
25pub_type
杂志文章,评审abstract::A method for seed proteome analysis using MALDI-TOF mass spectrometry is described. The data were used to estimate the genetic diversity degree among twelve genotypes of pepper (Capsicum). The resulting spectra were converted into a binary matrix consisting of 23 protein data sets, and genetic similarity values were c...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866043478482
更新日期:2004-02-01 00:00:00
abstract::Globulins are a major class of seed storage proteins which were thought to be enzymatically inactive. These proteins belong to the most ancient cupin superfamily. They can be graded into 11S legumin type and 7S vicilin type based on their sedimentation coefficients. Members from both classes share structural homology ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666161220112641
更新日期:2017-01-01 00:00:00
abstract::Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780363989
更新日期:2007-01-01 00:00:00
abstract::The formation of amyloid-like fibrils was studied by using the well-known serine protease trypsin as a model protein in the presence of ethanol as organic solvent. Trypsin forms amyloid-like fibrils in aqueous ethanol at pH = 7.0. The dye Congo red (CR) was used to detect the presence of amyloid-like fibrils in the sa...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666151002154324
更新日期:2015-01-01 00:00:00
abstract::Most proteinaceous pores are characterized as ionic channels. However, some are also involved in protein translocation through phospholipidic membranes. This concept has evolved slowly in cell biology and in biophysics, requiring the development of adapted electrical and biochemical methods. Protein translocation in m...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/09298665113209990076
更新日期:2014-03-01 00:00:00
abstract::Two cell-penetrating peptides, a Pro-rich peptide derivative, acetyl-(Val-Arg-Leu-Pro-Pro-Pro)(3)-Gly-Cys amide, and an octaarginine derivative, acetyl-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys amide, were prepared by the solid phase method. Each peptide was coupled to the heterobifunctional cross-linking reagent, 6-mal...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610790225978
更新日期:2010-02-01 00:00:00
abstract::The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and car...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170728144357
更新日期:2017-11-17 00:00:00
abstract::BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408472
更新日期:2002-10-01 00:00:00
abstract::Src is a non-receptor protein tyrosine kinase ubiquitously expressed in animals. It is involved in various cellular processes, including the innate immune response in mammals. However, less is known about the function of insect Src. Here we presented a homologue of Src in silkworm (Bombyx mori), named as BmSrc by phyl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666161129114520
更新日期:2017-01-01 00:00:00
abstract::Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may be a good target f...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608785849218
更新日期:2008-01-01 00:00:00
abstract::Allergy prevalence has increased worldwide over the last 25 years along with industrialization and westernized lifestyles. Indoor allergens are primarily responsible for the sensitization and development of atopic diseases. The main indoor allergens are known to be derived from various arthropods which account for up ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986607782541114
更新日期:2007-01-01 00:00:00
abstract::Human endophilin 1 (hEndo1) is a multifunctional protein that was found to bind a wide spectrum of prolinerich endocytic proteins through its Src homology 3 (SH3) domain. In order to elucidate the unknown biological functions of hEndo1, it is essential to find out the cytoplasmic components that hEndo1 recognizes and ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612802762606
更新日期:2012-10-01 00:00:00
abstract::The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, a competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775101715
更新日期:2006-01-01 00:00:00
abstract::Hepatitis C virus (HCV) triggers coordinated innate and adaptive response in host cell. HCV genome and proteins of the replicating virus are recognized as non-self-antigens by host cell to activate Toll Like Receptors (TLRs). Activated TLRs ultimately express cytokines, which can clear virus either by activating inter...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160419150136
更新日期:2016-01-01 00:00:00
abstract::Peptides with more than one biological activity are many a times multifunctional peptides. Two peptides with multifunctional properties from alpha (S2)-casein were stabilized in presence of cosolvents for their biological activities like ACE inhibition activity and antioxidant activity. These bioactive peptides in cos...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608784246416
更新日期:2008-01-01 00:00:00
abstract::To achieve the food-grade expression of bile salt hydrolase (BSH, EC 3.5.1.24) from Lactobacillus plantarum BBE7, the nisin controlled gene expression system (NICE), food-grade selection maker and signal peptide of Lactococcus lactis were used in this study. The open reading frame of BSH was optimized based on the cod...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150610094829
更新日期:2015-01-01 00:00:00
abstract::The mutation, conferring streptomycin and deoxyglucose resistance on cells, had profound effect on the kinetic and thermodynamic parameters inferring thermostabilization of beta-glucosidase from mutant 51 SM(r) of Cellulomonas biazotea. Free energy of activation for substrate binding, enthalpy and entropy of activatio...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053587183
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Cryptochrome is a flavin-binding blue-light photoreceptor that functions in growth and development in plants, the circadian clock in animals and navigation in birds. However, a lack of purified cryptochrome has hindered studies of the structure and function of this protein. In this study, we obtained a subst...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666181004112308
更新日期:2018-01-01 00:00:00
abstract::To investigate the processing of transforming growth factor beta1 (TGFbeta1) pro-protein by furin protease we expressed a GST-pro-TGFbeta1 fusion protein in bacteria. Analysis of the furin digestion pattern revealed the liberation of 12.5 kDa TGFbeta1 monomers. There was no evidence for cleavage of an alternative furi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610790963609
更新日期:2010-04-01 00:00:00
abstract::Marine species are comprising about a half of the whole global biodiversity; the sea offers an enormous resource for novel bioactive compounds. Several of the marine origin species show multifunctional bioactivities and characteristics that are useful for a discovery and/or reinvention of biologically active compounds...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160802160222
更新日期:2017-01-01 00:00:00
abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642760
更新日期:2011-12-01 00:00:00
abstract::Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866521666140320111720
更新日期:2014-07-01 00:00:00
abstract::Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788681724
更新日期:2009-01-01 00:00:00
abstract::To investigate the function of plant plasma membrane, proteins of rice plasma membrane were analyzed and the proteins changed by cold stress were identified. Plasma membrane proteins were purified with an aqueous two-phase partitioning method from root of rice seedlings, and activity of specific H(+)-ATPase localized ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609788490140
更新日期:2009-01-01 00:00:00
abstract::During spermiogenesis, the elongating rat spermatid chromatin undergoes a gradual process of condensation which is initiated in the round spermatids at "step 7" of cytodifferentation in stage VII and extending to elongated spermatids at "step 19" of cytodifferentiation in stage VIII. The mechanism of chromatin condens...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986611795714005
更新日期:2011-08-01 00:00:00
abstract::In 2008 cancer was identified by the World Health Organization (WHO) as one of four threats to human health and development. Since the early published reports of the first chemotherapeutic, mustine, in 1946, the anti-cancer drug and development industry has grown into a multi-billion dollar business enterprise. Worldw...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866521666140626102802
更新日期:2014-01-01 00:00:00
abstract::Mastoparans are tetradecapeptides found to be the major component of wasp venoms. These peptides possess a variety of biological activities. Three related mastoparans, mastoparan from Polistes jadwagae (MP-PJ), mastoparanX (MP-X) and its carboxyl-free C-terminal form (MP-X-COO-), were crystallized. X-ray diffraction d...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777145896
更新日期:2006-01-01 00:00:00
abstract::Sexual maturation and olfactory bulb defects found in prokineticin 2 (Pk2) and prokineticin receptor 2 (Pkr2) mutant mice resembling the phenotypic characteristics of Kallmann syndrome (KS), gave rise to the question of whether these genes would have a role in KS pathogenesis. Later, mutations in both genes were ident...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160517123331
更新日期:2016-01-01 00:00:00
abstract::Infections by antibiotic-resistant bacteria are becoming a great risk for human health, leading to an urgent need for new efficient antibacterial therapies. The short, proline-rich antimicrobial peptides from insects gained a lot of interest as a potential antibacterial treatment, having a low toxicity profile and bei...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113206660110
更新日期:2014-04-01 00:00:00
abstract::Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611796378693
更新日期:2011-10-01 00:00:00