Autoantibody reaction to myelin basic protein by plasma parvovirus B19 IgG in MS patients.

Abstract:

:The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, a competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased the binding of IgG to B19 antigen in a dose dependent fashion suggesting a possible link between parvovirus B19 and a subset of patients with clinical MS.

journal_name

Protein Pept Lett

authors

Thomas G,Rael L,Shimonkevitz R,Melamed I,Bar-Or D

doi

10.2174/092986606775101715

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

109-11

issue

2

eissn

0929-8665

issn

1875-5305

journal_volume

13

pub_type

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