COILCHECK: an interactive server for the analysis of interface regions in coiled coils.

abstract：BACKGROUND:Hepatitis C Virus (HCV) is a major cause of chronic liver disease in the world. Many studies showed that T-cell responses to HCV Nonstructural Protein 3 (NS3) play an important role in clearing acute HCV infections, thus NS3 can be considered as a suitable candidate antigen for development of a HCV therapeut...

journal_title：Protein and peptide letters

authors： Basirnejad M,Bolhassani A

更新日期：2018-01-01 00:00:00

abstract：:Migraine is a common neurologic condition marked by recurrent episodes of headache. Its pathophysiology is highly complex involving neuronal, inflammatory and vascular mechanisms. The Renin-Angiotensin System (RAS) can modulate all these mechanism, being a potential pharmacological target for migraine treatment. We ca...

journal_title：Protein and peptide letters

authors： Sassi KLM,Martins LB,de Miranda AS,Teixeira AL

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Nanosheets of SnO2 which an n-type semiconductor with a rutile-type crystalline structure are predominantly used as gas sensors. SnO2 nanosheets have a tetragonal crystal structure where growth along the c-axis is suppressed to form a sheet. The major exposed facets of SnO2 nanosheets have {110}, {101} and {...

journal_title：Protein and peptide letters

authors： Nakazawa H,Seta Y,Hirose T,Masuda Y,Umetsu M

更新日期：2018-01-01 00:00:00

abstract：:The cyclotides are a large family of plant proteins that have a cyclic backbone and a knotted arrangement of three conserved disulfide bonds. Despite the apparent complexity of their cystine knot motif it is possible to efficiently fold these proteins, as exemplified by oxidative folding studies on the prototypic cycl...

journal_title：Protein and peptide letters

authors： Craik DJ,Daly NL

更新日期：2005-02-01 00:00:00

abstract：:Spermadhesins are a family of secretory proteins expressed in the male genital tract of pig, horse and bull. Their function and structure have been widely studied, especially those isolated from boar. However, there are no data concerning spermadhesins isolated from buck. Buck seminal plasma was collected and subjecte...

journal_title：Protein and peptide letters

authors： Teixeira DI,Cavada BS,Sampaio AH,Havt A,Bloch C Jr,Prates MV,Moreno FB,Santos EA,Gadelha CA,Gadelha TS,Crisóstomo FS,Freitas VJ

更新日期：2002-08-01 00:00:00

abstract：:The development of a stable L-BDH chimera was attempted by exchanging whole domains between two native structural analogs, L-BDH and meso-BDH, because the S-configuration specificity of L-BDH is valuable from the standpoint of its application but its activity is unstable, whereas meso-BDH is stable. The domain chimera...

journal_title：Protein and peptide letters

authors： Shimegi T,Takusagawa Y,Ohtsuki T,Noda S,Kurisu G,Kusunoki M,Ui S

更新日期：2011-08-01 00:00:00

abstract：:Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus and bovine heart, respectively. Initial studies demonstrated that PNX is a rep...

journal_title：Protein and peptide letters

authors： Yuan T,Sun Z,Zhao W,Wang T,Zhang J,Niu D

更新日期：2017-01-01 00:00:00

abstract：:We used a de novo designed, beta-hairpin forming T1 peptide as a model to investigate the kinetics of peptide fibrogenesis by a combination of light scattering (LS), circular dichroism (CD), fluorescence, and atomic force microscopy (AFM). The results demonstrate that the T1 fibrogenesis undergoes a consecutive stepwi...

journal_title：Protein and peptide letters

authors： Wang C,Sha Y

更新日期：2010-04-01 00:00:00

abstract：:A halophilic nucleoside diphosphate kinase from a moderate halophile, Halomonas sp. 593 (593NDK), was found to be resistant to heat treatment, as indicated by the high level of activity recovery after heating at high temperatures. This is due to reversibility of thermal unfolding, not the high melting temperature, of ...

journal_title：Protein and peptide letters

authors： Tokunaga H,Oda Y,Yonezawa Y,Arakawa T,Tokunaga M

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Unstructured regions in proteins can vary from several amino acid residues to a completely disordered sequence. Since such regions play an important role in the protein functioning, much attention is being paid to their prediction. Special different programs are available for this purpose; however, predictio...

journal_title：Protein and peptide letters

authors： Deryusheva E,Machulin A,Nemashkalova E,Glyakina A,Galzitskaya O

更新日期：2018-01-01 00:00:00

abstract：:The Saccaromices cerevisiae D-serine dehydratase is a pyridoxal 5'-phosphate dependent enzyme that requires zinc for its function. It catalyses the conversion of D-serine into pyruvate and ammonia with the K(m) and k(cat) values of 0.39 mM and 13.1 s(-1) respectively. In this work, a new methodology for monitoring D-s...

journal_title：Protein and peptide letters

authors： Staiano M,Strianese M,Varriale A,Di Giovanni S,di Mase DS,Dell'Angelo V,Ruggiero G,Labella T,Pellecchia C,D'Auria S

更新日期：2012-06-01 00:00:00

abstract：:Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...

journal_title：Protein and peptide letters

authors： Charloteaux B,Lorin A,Brasseur R,Lins L

更新日期：2009-01-01 00:00:00

abstract：:We report a new prohormone convertase gene of insect origin, Trichoplusia ni furin, which was cloned from BTI-Tn-5B-4 (Tn5) insect cells. We constructed a truncated mutant that lacked Cys-rich repeated segments. Using baculovirus expression system and standard enzymatic assay, we obtained recombinant Tn furin and eval...

journal_title：Protein and peptide letters

authors： Wang L,Xu D,Qian M,Yang G,Wu X

更新日期：2006-01-01 00:00:00

abstract：:We present the results of a study on the influence of albumin and prolactin concentrations and intravascular fluid pH on vein permeability for albumin. Permeability conditions were simulated depending on albumin concentration, pH value and prolactin concentration. In research model an in vitro method was applied using...

journal_title：Protein and peptide letters

authors： Dolińska B,Caban A,Cierpka L,Ryszka F

更新日期：2014-01-01 00:00:00

abstract：:The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...

journal_title：Protein and peptide letters

authors： Joshi RR,Manda C

更新日期：2007-01-01 00:00:00

abstract：:Alpha-gliadins isolated by carboxymethylcellulose chromatography contain noncovalently bound glucose probably due to contaminating proteoglycans and to material shed from the column. Traces of carbohydrate remain strongly bound to alpha-gliadins even after harsh denaturation, but our results indicate alpha-gliadins ar...

journal_title：Protein and peptide letters

authors： Turner JB,Garner GV,Gordon DB,Brookes SJ,Smith CA

更新日期：2002-02-01 00:00:00

abstract：:After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show th...

journal_title：Protein and peptide letters

authors： Wu G,Yan S

更新日期：2008-01-01 00:00:00

abstract：:In 2008 cancer was identified by the World Health Organization (WHO) as one of four threats to human health and development. Since the early published reports of the first chemotherapeutic, mustine, in 1946, the anti-cancer drug and development industry has grown into a multi-billion dollar business enterprise. Worldw...

journal_title：Protein and peptide letters

authors： Li Q,Yi L,Marek P

更新日期：2014-01-01 00:00:00

abstract：:Cinnamomin is a type II ribosome-inactivating protein (RIP) and its A-chain (CTA) is a RNA N-glycosidase. It is observed that modification of tyrosine residues by N-acetylimidazole (N-AI) causes almost complete loss of CTA activity. Adenine partially protects tyrosine residues from modification by N-AI. It is proposed...

journal_title：Protein and peptide letters

authors： Xu H,Liu WY

更新日期：2003-10-01 00:00:00

abstract：:Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone Psi, omega and Phi torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also...

journal_title：Protein and peptide letters

authors： Gupta S,Grail BM,Payne JW

更新日期：2002-04-01 00:00:00

abstract：:The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in m...

journal_title：Protein and peptide letters

authors： Fulda S,Linseisen J,Wolfram G,Himmerich S,Gedrich K,Pollmächer T,Himmerich H

更新日期：2010-11-01 00:00:00

abstract：:The physiological stability curve--a plot of the free energy of unfolding versus temperature--is calculated for hen egg white lysozyme from a combination of extrapolated unfolding thermodynamic data from reversible conditions and isothermal titrations with guanidine hydrochloride. The shape of the curve suggests the e...

journal_title：Protein and peptide letters

authors： Younvanich SS,Britt BM

更新日期：2006-01-01 00:00:00

abstract：:Endonuclease tRNase Z catalyzes the generation of the mature 3' end of tRNA precursors through specific endonucleolytic cleavage. The enzyme has been characterized from organisms representative of all domains of life as well as from organelles, and the crystal structure of three bacterial enzymes has been determined. ...

journal_title：Protein and peptide letters

authors： Ceballos M,Vioque A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Paraoxonase (PON; arilesterase, [EC 3.1.8.1]) is an enzyme from the group arilesterases (ARE). This enzyme is capable of hydrolyzing paraoxone which is the active metabolite of parathion, an organic phosphorus insecticide. PON activity was found to be low in individuals prone to development of atherosclerosi...

journal_title：Protein and peptide letters

authors： Yılmaz A,Dilek E

更新日期：2019-01-01 00:00:00

abstract：:Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...

journal_title：Protein and peptide letters

authors： Yu DY,Qiao N,Liu P,Wei Q

更新日期：2009-01-01 00:00:00

abstract：:Human butyrylcholinesterase (BuChE) is a serine enzyme present in most organs and plasma. No clear physiological function has yet been assigned to BuChE, but it is a pharmacologically and toxicologically important enzyme that plays a role in degradation of numerous ester-containing drugs and poisonous esters. Thus, Bu...

journal_title：Protein and peptide letters

authors： Masson P,Carletti E,Nachon F

更新日期：2009-01-01 00:00:00

abstract：:Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...

journal_title：Protein and peptide letters

authors： Chen Y,Tao K,Ji W,Makam P,Rencus-Lazar S,Gazit E

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Assisted Reproduction Techniques (ART) have significantly advanced since the first successful In Vitro Fertilization (IVF). However, most in vitro-produced embryos fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individualised treatments, and the assessment of ...

journal_title：Protein and peptide letters

authors： De Rose MB,Piccolomini MM,Soares Belo AS,Borges E Jr,Filho FF

更新日期：2018-01-01 00:00:00

abstract：:To investigate the function of plant plasma membrane, proteins of rice plasma membrane were analyzed and the proteins changed by cold stress were identified. Plasma membrane proteins were purified with an aqueous two-phase partitioning method from root of rice seedlings, and activity of specific H(+)-ATPase localized ...

journal_title：Protein and peptide letters

authors： Hashimoto M,Toorchi M,Matsushita K,Iwasaki Y,Komatsu S

更新日期：2009-01-01 00:00:00

abstract：:For biophysical studies using heteronuclear NMR analysis of amyloid beta peptide, construction of an efficient and high yield expression system of uniformly isotopic labeled amyloid beta peptide is desirable. Here we succeeded in obtaining (15)N-labeled amyloid beta 1-40 expressed by attachment to hen egg white lysozy...

journal_title：Protein and peptide letters

authors： Nagata-Uchiyama M,Yaguchi M,Hirano Y,Ueda T

更新日期：2007-01-01 00:00:00