Abstract:
:After several studies on prediction of mutation, we examine the effect of three sampling strategies, the sampling based on years, the sampling based on number of mutations, and the sampling based on the unpredictable portion of amino-acid pairs, on the prediction performance in H5N1 hemagglutinins. The results show that the sampling strategy does play an important role in prediction, which should be taken into account when predicting the next generation of mutations in proteins from influenza A virus.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Wu G,Yan Sdoi
10.2174/092986608785133735subject
Has Abstractpub_date
2008-01-01 00:00:00pages
731-8issue
7eissn
0929-8665issn
1875-5305journal_volume
15pub_type
杂志文章abstract::G-protein betagamma dimers are prime regulators transmitting extracellular signals to wide-ranging cellular effectors including phosphoinositide 3-kinase (PI3K) isoforms beta and gamma. Recombinant Gbetagamma purified from Sf9 cells via metal-affinity and anion exchange chromatography exhibited a wortmannin-insensitiv...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789055340
更新日期:2009-01-01 00:00:00
abstract::Interaction between S100P and its target protein is an essential step in several cellular functions. The amphipathic mellitin peptide binds tightly to S100P protein in the presence of calcium cation. Since little is known about the recognition sequence, mellitin interaction form a model for S100P. Interaction between ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775338380
更新日期:2006-01-01 00:00:00
abstract::Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood cells function as bioreactors to deplete bloodstream substrate. This delivery system provides improved pharmacodynamics with protection from circulating proteoly...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:
更新日期:2013-04-01 00:00:00
abstract::Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and r...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986612799080248
更新日期:2012-02-01 00:00:00
abstract::C-terminal peptide alpha-thioesters are valuable intermediates in the synthesis/semisynthesis of proteins by native chemical ligation. They are prepared either by solid-phase peptide synthesis (SPPS) or biosynthetically by protein splicing techniques. The present paper reviews the different methods available for the c...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866054864166
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666191014144015
更新日期:2020-01-01 00:00:00
abstract::Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide syn...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791306625
更新日期:2010-07-01 00:00:00
abstract::Mastoparans are tetradecapeptides found to be the major component of wasp venoms. These peptides possess a variety of biological activities. Three related mastoparans, mastoparan from Polistes jadwagae (MP-PJ), mastoparanX (MP-X) and its carboxyl-free C-terminal form (MP-X-COO-), were crystallized. X-ray diffraction d...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777145896
更新日期:2006-01-01 00:00:00
abstract::Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9), a subunit of an Elongin C-cullin-SOCS box (ECS) E3 ubiquitin ligase complex, is believed to be involved in specific substrate-recognition for ubiquitination and degradation. In fact, this specific substrate-recognition is determined by th...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787601688
更新日期:2009-01-01 00:00:00
abstract::Retro-ACP (74-65) fragment was synthesized on a novel 4% tri-(propylene glycol) glycerolate diacrylate cross-linked polystyrene (PS-TRPGGDA) support. The peptide is grown from the functional site present in the cross-linker, which makes it unique and cost-effective among other styrene based polymer supports. A compara...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478753
更新日期:2003-10-01 00:00:00
abstract::Plants reproductive phase, when grain yield and consequently farmers' investment is most in jeopardy, is considered as the most sensitive stage to drought stress. In this study, we aimed to explore the proteomic response of wheat anther at meiosis stage in a drought tolerant, Darab, and susceptible, Shiraz, wheat geno...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666161130143446
更新日期:2017-01-01 00:00:00
abstract::α-Synuclein forms amyloid deposits in the dopaminergic neurons; a process that is believed to contribute to the Parkinson's disease. An emerging theme in amyloid research is the hypothesis that the toxic species produced during amyloid formation share common physic-chemical features and exert their effects by common m...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150209142649
更新日期:2015-01-01 00:00:00
abstract::Cationic antimicrobial peptides (AMPs) are among the best studied antimicrobial factors expressed in the respiratory tract. AMPs are released by epithelial cells and immune cells into the airway surface liquid covering the epithelial surfaces of the lung where they act as endogenous antibiotics. Plenty of studies show...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/09298665113206660100
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180221122529
更新日期:2018-01-01 00:00:00
abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642760
更新日期:2011-12-01 00:00:00
abstract::Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200212123542
更新日期:2020-01-01 00:00:00
abstract::Chemical probing of histidine residues using specific modifiers, iodoacetic acid (IAA) and diethylpyrocarbonate (DEP) resulted in the inactivation of phytase (phy A). The kinetic theory of the substrate reaction during the modification of enzyme activity was applied to a study of the kinetics of the course of inactiva...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777145788
更新日期:2006-01-01 00:00:00
abstract::With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760306
更新日期:2010-09-01 00:00:00
abstract::Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus and bovine heart, respectively. Initial studies demonstrated that PNX is a rep...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170207154417
更新日期:2017-01-01 00:00:00
abstract::Hepatitis C virus and related viruses in the Flaviviridae family (such as dengue virus, yellow fever virus or West Nile virus) are amongst the most important human pathogens, causing substantial morbidity and mortality world-wide. The production of viral progeny in Flaviviridae is orchestrated by the small, multifunct...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986610791498911
更新日期:2010-08-01 00:00:00
abstract::BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408472
更新日期:2002-10-01 00:00:00
abstract::Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787316243
更新日期:2009-01-01 00:00:00
abstract::Sexual maturation and olfactory bulb defects found in prokineticin 2 (Pk2) and prokineticin receptor 2 (Pkr2) mutant mice resembling the phenotypic characteristics of Kallmann syndrome (KS), gave rise to the question of whether these genes would have a role in KS pathogenesis. Later, mutations in both genes were ident...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160517123331
更新日期:2016-01-01 00:00:00
abstract::Michael Laskowski Jr. (1930-2004) was a pioneer in the field of Standard mechanism serine proteinase inhibitors. He made numerous important contributions in the field. This article highlights some of his most important contributions such as the discovery of the reactive site in serine proteinase inhibitors, the propos...
journal_title:Protein and peptide letters
pub_type: 传,历史文章,杂志文章
doi:10.2174/0929866054395347
更新日期:2005-07-01 00:00:00
abstract::Monoclonal antibody (mAb) MN423 recognizes Alzheimer's disease specific conformation of tau protein assembled into paired helical filaments (PHF). Since the three-dimensional structure of PHF is currently unavailable, the structure of MN423 binding site could provide important information about PHF conformation with t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606778256180
更新日期:2006-01-01 00:00:00
abstract::Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplas...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608783489607
更新日期:2008-01-01 00:00:00
abstract::Familial mediterranean fever (FMF) is a systemic disorder characterized by recurrent attacks of fever and polyserositis. In FMF, several pro-inflammatory cytokines have been found to be elevated during the attacks. In recent years, it is shown that some proteins originated from adipose tissue play important role in in...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610792231555
更新日期:2010-10-01 00:00:00
abstract::Numerous small molecules including cytokines primarily associated with immune response have been shown to play a role in normal mesenchymal stem cells (MSC) and tumour cells' communication. One characteristic that distinguishes MSC from fibroblast and other cells of mesenchymal origin is their pro-tumour migratory beh...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866522666150131123808
更新日期:2015-01-01 00:00:00
abstract::Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate. In this paper, we examined the sequences and structures of the MutT/Nudix...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986608783330350
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Hepatitis C Virus (HCV) is a major cause of chronic liver disease in the world. Many studies showed that T-cell responses to HCV Nonstructural Protein 3 (NS3) play an important role in clearing acute HCV infections, thus NS3 can be considered as a suitable candidate antigen for development of a HCV therapeut...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180925145304
更新日期:2018-01-01 00:00:00