Presence of distinct virtual backbone torsion angles in dipeptide conformers.

abstract：:Self-Interacting Proteins (SIPs), whose two or more copies can interact with each other, have significant roles in cellular functions and evolution of Protein Interaction Networks (PINs). Knowing whether a protein can act on itself is important to understand its functions. Previous studies on SIPs have focused on thei...

journal_title：Protein and peptide letters

authors： Qu J,Zhao Y,Zhang L,Cai SB,Ming Z,Wang CC

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Microalgae have been suggested as promising feedstocks of significant biotechnological interest due to their enormous potential for the sustainable production of industrially valuable compounds such as lipids/fatty acids, proteins, metabolites, pigments, and biofuels. However, exploitation of algal biomass f...

journal_title：Protein and peptide letters

authors： Khan AZ,Shahid A,Cheng H,Mahboob S,Al-Ghanim KA,Bilal M,Liang F,Nawaz MZ

更新日期：2018-01-01 00:00:00

abstract：:Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies. The enzyme-loaded red blood cells function as bioreactors to deplete bloodstream substrate. This delivery system provides improved pharmacodynamics with protection from circulating proteoly...

journal_title：Protein and peptide letters

authors： Agrawal V,Woo JH,Borthakur G,Kantarjian H,Frankel AE

更新日期：2013-04-01 00:00:00

abstract：:Coiled coils are important structural modules and domains of protein-protein interactions. Further, they provide the required framework to proteins, like kinesins, myosins and SNAREs, which are either structural or involved in transport of biomolecules. We provide an interactive webserver to measure the strength of in...

journal_title：Protein and peptide letters

authors： Alva V,Syamala Devi DP,Sowdhamini R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Paraoxonase (PON; arilesterase, [EC 3.1.8.1]) is an enzyme from the group arilesterases (ARE). This enzyme is capable of hydrolyzing paraoxone which is the active metabolite of parathion, an organic phosphorus insecticide. PON activity was found to be low in individuals prone to development of atherosclerosi...

journal_title：Protein and peptide letters

authors： Yılmaz A,Dilek E

更新日期：2019-01-01 00:00:00

abstract：:The study of rat proteins is an indispensable task in experimental medicine and drug development. The function of a rat protein is closely related to its subcellular location. Based on the above concept, we construct the benchmark rat proteins dataset and develop a combined approach for predicting the subcellular loca...

journal_title：Protein and peptide letters

authors： Shi R,Xu C

更新日期：2011-06-01 00:00:00

abstract：:Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur. ...

journal_title：Protein and peptide letters

authors： Shiraishi N,Inai Y,Ihara Y

更新日期：2009-01-01 00:00:00

abstract：:Heat shock proteins (HSPs) consist of a large group of proteins with negligible expressions under physiological conditions. Their expressions are highly induced under stress conditions and they are ubiquitously expressed in various tissues and organs. HSPs possess chaperone functions, thus facilitating the correct fol...

journal_title：Protein and peptide letters

authors： Lu WJ,Lee NP,Fatima S,Luk JM

更新日期：2009-01-01 00:00:00

abstract：:Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...

journal_title：Protein and peptide letters

authors： Agueci F,Polticelli F,Sinibaldi F,Piro MC,Santucci R,Fiorucci L

更新日期：2007-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are short, cationic, membrane-interacting proteins that exhibit broad-spectrum antimicrobial activity, and are hence of significant biomedical interest. They exert their activity by selectively binding to and lysing target cell membranes, but the precise molecular details of their mechani...

journal_title：Protein and peptide letters

authors： Bond PJ,Khalid S

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:It is currently believed that protein folding rates are influenced by protein structure, environment and temperature, amino acid sequence and so on. We have been working for long to determine whether and in what ways mRNA affects the protein folding rate. A large number of palindromes aroused our attention i...

journal_title：Protein and peptide letters

authors： Li R,Li H,Yang S,Feng X

更新日期：2020-01-01 00:00:00

abstract：:A Surface Plasmon Resonance Imaging (SPRI) sensor has been developed for highly selective determination of cathepsin D (Cat D) or/and E (Cat E). The sensor contains immobilised pepstatin A, which binds aspartyl proteases from solution. Pepstatin A activated with N-Hydroxysuccinimide (NHS) and N-Ethyl-N'-(3-dimethylami...

journal_title：Protein and peptide letters

authors： Gorodkiewicz E,Regulska E

更新日期：2010-09-01 00:00:00

abstract：:DNA ligase is an important enzyme and it plays vital role in the replication and repair; also catalyzes nick joining between adjacent bases of DNA. The NAD(+) dependent DNA ligase is selectively present in eubacteria and few viruses; but missing in humans. Homology modeling was used to generate 3-D structure of NAD(+)...

journal_title：Protein and peptide letters

authors： Singh V,Somvanshi P

更新日期：2010-02-01 00:00:00

abstract：:We used a de novo designed, beta-hairpin forming T1 peptide as a model to investigate the kinetics of peptide fibrogenesis by a combination of light scattering (LS), circular dichroism (CD), fluorescence, and atomic force microscopy (AFM). The results demonstrate that the T1 fibrogenesis undergoes a consecutive stepwi...

journal_title：Protein and peptide letters

authors： Wang C,Sha Y

更新日期：2010-04-01 00:00:00

abstract：:The present paper reviews the use of expressed protein ligation for the biosynthesis of backbone cyclized polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibil...

journal_title：Protein and peptide letters

authors： Kimura R,Camarero JA

更新日期：2005-11-01 00:00:00

abstract：:S-adenosyl-l-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 A, b = 86.31 A, and c = 335.6 A. There are four subunits (one tetramer) per as...

journal_title：Protein and peptide letters

authors： Tanaka N,Kusakabe Y,Shiraiwa K,Sakamoto Y,Nakanishi M,Kitade Y,Nakamura KT

更新日期：2004-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic disease with an autoimmunological background. RA is mostly characterized by systemic inflammation and injuries of synovial joints. There is a hypothesis that bacterial infections may be connected with development of the disease. It has been suggested that molecular mimicry betwee...

journal_title：Protein and peptide letters

authors： Konieczna I,Kwinkowski M,Kolesińska B,Kamiński Z,Zarnowiec P,Kaca W

更新日期：2012-11-01 00:00:00

abstract：:Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, a...

journal_title：Protein and peptide letters

authors： Yu DY,Qiao N,Liu P,Wei Q

更新日期：2009-01-01 00:00:00

abstract：:Coordination of cell growth and cell division is very important for living organisms in order for these to develop harmonically. The present research is concerned with the purification and characterization of a new peptide hormone, namely ZmIGF (Zea mays insulin-like growth factor), which regulates growth and cell div...

journal_title：Protein and peptide letters

authors： Rodríguez-López CD,Rodríguez-Romero A,Aguilar R,de Jiménez ES

更新日期：2011-01-01 00:00:00

abstract：:A significant association between increased level of blood homocysteine (hyperhomocysteinimia) and various eye pathological disorders including cataract has been reported. This metabolic byproduct is converted into a highly reactive cyclic thioester compound, homocysteine thiolactone (HCTL), which can potentially reac...

journal_title：Protein and peptide letters

authors： Hajjari S,Masoudi R,Javadi S,Hemmateenejad B,Yousefi R

更新日期：2016-01-01 00:00:00

abstract：:A proof-of-principle methodology is presented in which all commercially-available cysteine (Cys) and selenocysteine (Sec) solid phase peptide synthesis (SPPS) derivatives are synthesized in high yield from easily prepared protected dichalcogenide precursors. A Zn-mediated biphasic reduction process applied to a series...

journal_title：Protein and peptide letters

authors： Flemer S

更新日期：2014-01-01 00:00:00

abstract：:The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...

journal_title：Protein and peptide letters

authors： Saikumari YK,Ravindra G,Balaram P

更新日期：2006-01-01 00:00:00

abstract：:Human histatins are histidine-rich, low molecular weight salivary proteins that contribute to the immune system of the oral cavity. In this work, nucleotide sequences of the HIS1 (coding for histatin 1) and HIS2 (coding for histatin 3) genes, homologous to the human ones, have been sequenced and analysed in five prima...

journal_title：Protein and peptide letters

authors： Padovan L,Segat L,Pontillo A,Antcheva N,Tossi A,Crovella S

更新日期：2010-07-01 00:00:00

abstract：:Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide syn...

journal_title：Protein and peptide letters

authors： Bayryamov SG,Vassilev NG,Petkov DD

更新日期：2010-07-01 00:00:00

abstract：:We investigated the in vitro antibiotic activity of the 19-amino acid antimicrobial peptide HP (2-20), derived from the N-terminus of Helicobacter pylori Ribosomal Protein L1 (RPL1), against antibiotic susceptible and resistant pathogens from a patient with gallstones. HP (2-20) was active against antibiotic-susceptib...

journal_title：Protein and peptide letters

authors： Park Y,Hahm JS,Hahm KS

更新日期：2006-01-01 00:00:00

abstract：:A computer-aided docking study was carried out to quickly clarify the binding structure of the ligand-receptor complex between bisphenol A (BPA), a well-known endocrine disruptor, and estrogen-related receptor gamma (ERRgamma). The resulting complex indicated that BPA binds to the ligand-binding pocket of ERRgamma wit...

journal_title：Protein and peptide letters

authors： Nose T,Shimohigashi Y

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:CsaA is among the few chaperones which are present in both bacteria and archaea, but absent in eukaryotes. There are no reports on interactome analysis of CsaA from archaea, till date. Identification of binding partners of CsaA might be helpful in understanding CsaA-associated processes in Picrophilus torrid...

journal_title：Protein and peptide letters

authors： Singhal N,Sharma A,Aswal M,Singh N,Kumar M,Goel M

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...

journal_title：Protein and peptide letters

authors： Ikram Ul Haq,Shakoor S,Nawaz A,Arshad Y,Mukhtar H

更新日期：2020-09-16 00:00:00

abstract：:VML is a lectin from Vatairea macrocarpa seeds that has various biological activities. Here, we describe three new lectin isoforms from V. macrocarpa identified through genomic DNA analysis. One of these isoforms has high similarity to VML, while another that has noteworthy differences. We have denoted the new isoform...

journal_title：Protein and peptide letters

authors： Alves Filho JG,do Nascimento AS,Gondim AC,Pereira RH,da Cunha RM,Nagano CS,Teixeira EH,Nascimento KS,Cavada BS

更新日期：2013-11-01 00:00:00

abstract：:Transgelin was solubly expressed in E. coli. Crystals of transgelin have been grown at 291K using sodium formate or PEG-4000 as precipitants. X-ray diffraction by the crystal extends to 2.3 A resolution. The crystal belongs to the space group P2(1), with the unit cell parameters a=39.3, b=61.9, c=56.0 A and beta=90.2 ...

journal_title：Protein and peptide letters

authors： Liao X,Li S,Lou Z,Chen Z,Bartlam M

更新日期：2007-01-01 00:00:00