The stability curve of hen egg white lysozyme.

abstract：:Successful approaches of de novo protein design suggest a great potential to create novel structural folds and to understand natural rules of protein folding. For these purposes, smaller and simpler de novo proteins have been developed. Here, we constructed smaller proteins by removing the terminal sequences from stab...

journal_title：Protein and peptide letters

authors： Okura H,Takahashi T,Mihara H

更新日期：2012-06-01 00:00:00

abstract：:Utilizing different computational methods; phosphorylation, O-GlcNAc modification and Yin Yang sites are predicted in HMGN-1. Prediction results suggest that interplay of phosphorylation and O-GlcNAc modification regulates binding and removal of HMGN-1 with the nucleosome and its translocation from nucleus to cytoplas...

journal_title：Protein and peptide letters

authors： Ahmad I,Khan TS,Hoessli DC,Walker-Nasir E,Kaleem A,Shakoori AR,Nasir-ud-Din

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The biocatalytic oxidation of UDP-glucose in the presence of NAD+ is catalyzed by UDP-glucose dehydrogenases. OBJECTIVES:The main objective of this study was the characterization of a UDP-glucose dehydrogenase (AmUGD) from Akkermansia muciniphila, a bacterium originally isolated from human faeces in an anae...

journal_title：Protein and peptide letters

authors： Wei S,Zhang XY,Sun Y,Conway LP,Liu L

更新日期：2017-01-01 00:00:00

abstract：:Bromelain inhibitor, "bromein", is a proteinase-inhibitor specific to the cysteine proteinase bromelain from pineapple stem. In the stem, eight bromein isoforms are known to exist, and each isoform has a short peptide (light chain) and a long one (heavy chain) with five disulfide bonds. The three-dimensional structure...

journal_title：Protein and peptide letters

authors： Hatano KI,Takahashi K,Tanokura M

更新日期：2018-01-01 00:00:00

abstract：:Aspergillus sp. phytase contains five disulfide bonds. In order to elucidate their role, the reactivation and refolding of phytase in the absence and presence of dithiothreitol (DTT) was investigated. The results indicated that the disulfide bonds play an important role in the catalytic activity and conformational sta...

journal_title：Protein and peptide letters

authors： Song GY,Wang XY,Wang M

更新日期：2005-08-01 00:00:00

abstract：:Although the tertiary structures of mitochondrial cytochromes c (cyts c) seem to be remarkably similar, there are variations in their amino acid sequences, stability and functional properties. GdnHCl-induced unfolding experiments on engineered yeast and horse cyt c were carried out with the aim to to clarify, at molec...

journal_title：Protein and peptide letters

authors： Agueci F,Polticelli F,Sinibaldi F,Piro MC,Santucci R,Fiorucci L

更新日期：2007-01-01 00:00:00

abstract：:3-Isopropylmalate dehydrogenase (IPMDH) from Mycobacterium tuberculosis (Mtb) may be a target for specific drugs against this pathogenic bacterium. We have expressed and purified Mtb IPMDH and determined its physicalchemical and enzymological properties. Size-exclusion chromatography and dynamic light scattering measu...

journal_title：Protein and peptide letters

authors： Graczer E,Bacso A,Konya D,Kazi A,Soos T,Molnar L,Szimler T,Beinrohr L,Szilagyi A,Zavodszky P,Vas M

更新日期：2014-01-01 00:00:00

abstract：:A significant association between increased level of blood homocysteine (hyperhomocysteinimia) and various eye pathological disorders including cataract has been reported. This metabolic byproduct is converted into a highly reactive cyclic thioester compound, homocysteine thiolactone (HCTL), which can potentially reac...

journal_title：Protein and peptide letters

authors： Hajjari S,Masoudi R,Javadi S,Hemmateenejad B,Yousefi R

更新日期：2016-01-01 00:00:00

abstract：:The catalytic regions of Protein Kinases are known to have similarity in primary chains. However, it is not known whether there is a signature profile specific to a particular catalytic region? Whether the signature profile, if any, is unique to a protein kinases family in a particular species or in a group of species...

journal_title：Protein and peptide letters

authors： Joshi RR,Manda C

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Fruit juice clarification is a challenging aspect of beverage industry which needs to be addressed for economical and hygienic production of fruit juices. OBJECTIVE:Current study is focused on the complete purification, characterization and thermodynamic analysis of an efficient mannanase enzyme to analyze ...

journal_title：Protein and peptide letters

authors： Ikram Ul Haq,Shakoor S,Nawaz A,Arshad Y,Mukhtar H

更新日期：2020-09-16 00:00:00

abstract：:A pivotal feature that underlies the development of neurodegeneration is the accumulation of protein aggregates. In response, eukaryotic cells have evolved sophisticated quality control mechanisms to identify, repair and/or eliminate the misfolded abnormal proteins. Chaperones identify any otherwise abnormal conformat...

journal_title：Protein and peptide letters

authors： Eldeeb MA,Ragheb MA,Esmaili M,Hussein F

更新日期：2020-01-01 00:00:00

abstract：:A novel cellulase was isolated from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius ATCC27009 grown in medium containing carboxymethylcellulose. The enzyme is a glycosylated monomer of 56.2 kDa, relatively thermostable, with optimal pH and temperature of 4.0 and 65 degrees C, respectively. Enzymatic as...

journal_title：Protein and peptide letters

authors： Morana A,Esposito A,Maurelli L,Ruggiero G,Ionata E,Rossi M,La Cara F

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...

journal_title：Protein and peptide letters

authors： Francisco CC,Luis CJ,Marina EJ,Javier CF,Alexis LA,Del Carmen SH,Alfredo RI

更新日期：2019-01-01 00:00:00

abstract：:Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage...

journal_title：Protein and peptide letters

authors： dos Santos LD,Dias NB,Roberto J,Pinto AS,Palma MS

更新日期：2009-01-01 00:00:00

abstract：:The study of rat proteins is an indispensable task in experimental medicine and drug development. The function of a rat protein is closely related to its subcellular location. Based on the above concept, we construct the benchmark rat proteins dataset and develop a combined approach for predicting the subcellular loca...

journal_title：Protein and peptide letters

authors： Shi R,Xu C

更新日期：2011-06-01 00:00:00

abstract：:The superoxide anion radical is a highly reactive toxic species produced during the metabolic processes. A number of copper (II) complexes with amino acids and peptides are known to show superoxide dismutase (SOD) like activity. The design and application of synthetic low molecular weight metal complexes as SOD mimics...

journal_title：Protein and peptide letters

authors： Singh RK,Srivastava VC,Singh UP

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Type VI Secretion System (T6SS) has been found in approximately onequarter of the gram-negative bacterial species, and its structural characteristics appear to slightly differ from species to species. The genes encoding T6SS are designated as type six secretion A-M (tssA-M). The expression of the tss gene cl...

journal_title：Protein and peptide letters

authors： Ok CK,Chang JH

更新日期：2019-01-01 00:00:00

abstract：:Monoclonal antibody (mAb) MN423 recognizes Alzheimer's disease specific conformation of tau protein assembled into paired helical filaments (PHF). Since the three-dimensional structure of PHF is currently unavailable, the structure of MN423 binding site could provide important information about PHF conformation with t...

journal_title：Protein and peptide letters

authors： Csóková N,Skrabana R,Urbániková L,Kovácech B,Popov A,Sevcík J,Novák M

更新日期：2006-01-01 00:00:00

abstract：:Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...

journal_title：Protein and peptide letters

authors： Yamamoto H,Iguchi K,Ohno S,Yokogawa T,Nishikawa K,Hoshino M

更新日期：2011-10-01 00:00:00

abstract：:In this paper(1) we present a novel framework for protein secondary structure prediction. In this prediction framework, firstly we propose a novel parameterized semi-probability profile, which combines single sequence with evolutionary information effectively. Secondly, different semi-probability profiles are respecti...

journal_title：Protein and peptide letters

authors： Huang DS,Huang X

更新日期：2006-01-01 00:00:00

abstract：:Src is a non-receptor protein tyrosine kinase ubiquitously expressed in animals. It is involved in various cellular processes, including the innate immune response in mammals. However, less is known about the function of insect Src. Here we presented a homologue of Src in silkworm (Bombyx mori), named as BmSrc by phyl...

journal_title：Protein and peptide letters

authors： Li X,Hua X,Song L,Xia Q,Wang F

更新日期：2017-01-01 00:00:00

abstract：:With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...

journal_title：Protein and peptide letters

authors： Yang L,Xia JF,Gui J

更新日期：2010-09-01 00:00:00

abstract：:Prediction of thermophilic and mesophilic protein plays a crucial role in both biochemistry and bioengineering. In this study, a different mode of pseudo amino acid composition (PseAAC) was proposed to formulate the protein samples by integrating the amino acid composition, the physic chemical features, as well as the...

journal_title：Protein and peptide letters

authors： Wang D,Yang L,Fu Z,Xia J

更新日期：2011-07-01 00:00:00

abstract：:The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, s...

journal_title：Protein and peptide letters

authors： Bera S,Gazit E

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Unstructured regions in proteins can vary from several amino acid residues to a completely disordered sequence. Since such regions play an important role in the protein functioning, much attention is being paid to their prediction. Special different programs are available for this purpose; however, predictio...

journal_title：Protein and peptide letters

authors： Deryusheva E,Machulin A,Nemashkalova E,Glyakina A,Galzitskaya O

更新日期：2018-01-01 00:00:00

abstract：:Ewing's Sarcoma transcript-2 (EAT2) also known as SH2D1B is involved in regulation of signalling lymphocytic activation molecule (SLAM) family receptor functions. Cytoplasmic tails of SLAM family receptors contain tyrosine residues which mediate the downstream signal transduction through their phosphorylation. EAT2, c...

journal_title：Protein and peptide letters

authors： Taha M,Nezerwa E,Nam HJ

更新日期：2016-01-01 00:00:00

abstract：:The present paper reviews the use of expressed protein ligation for the biosynthesis of backbone cyclized polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibil...

journal_title：Protein and peptide letters

authors： Kimura R,Camarero JA

更新日期：2005-11-01 00:00:00

abstract：:Mastoparans are tetradecapeptides found to be the major component of wasp venoms. These peptides possess a variety of biological activities. Three related mastoparans, mastoparan from Polistes jadwagae (MP-PJ), mastoparanX (MP-X) and its carboxyl-free C-terminal form (MP-X-COO-), were crystallized. X-ray diffraction d...

journal_title：Protein and peptide letters

authors： Wang F,Liu X,Li H,Lang X,Peng H,Liu S,Jiang T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:NMAAP1 plays a role in regulating macrophage differentiation to the M1 type and exerting antitumoral functions. It is not clear what role and mechanism NMAAP1 does play in the reversal of macrophages from M1 to M2. METHODS:We detected the typing of macrophages with high or low expression of NMAAP1 by QPCR a...

journal_title：Protein and peptide letters

authors： Liu Q,Zhu P,Liu S,Tang M,Wang Y,Tian Y,Jin Z,Li D,Yan D

更新日期：2019-01-01 00:00:00

abstract：:PD-L1 is a highly glycosylated type 1 ribosome inactivating protein, from Phytolacca dioica leaves, with the peculiarity to act also as a DNase. PD-L1 has been successfully crystallized using vapour diffusion and seeding techniques. Crystals belong to the monoclinic C2 space group, with unit cell dimensions a=161.01, ...

journal_title：Protein and peptide letters

authors： Ruggiero A,Chambery A,Di Maro A,Mastroianni A,Parente A,Berisio R

更新日期：2007-01-01 00:00:00