The Structural Alteration and Aggregation of Bovine Lens Gamma-Crystallin by Homocysteinylation; The Pathomechanism Underlying Cataract Development During Hyperhomocysteinimia.

abstract：:Annual ryegrass (Lolium multiflorum) is widely used as a cool-season forage grass for its luxuriant growth, palatable and high digestible. To investigate the salt tolerance mechanism in annual ryegrass under salt stress, salt-tolerant genotype 'R102-3' and salt-sensitive genotype 'Tetragold' were subject to 300mmol/L ...

journal_title：Protein and peptide letters

authors： Wang X,Ma X,Xinquan-Zhang,Linkai-Huang,Li Z,Nie WX

更新日期：2016-01-01 00:00:00

abstract：:The high technical standard of current peptide chemistry, which has evolved over the past three decades, has profoundly facilitated the investigation of proteins and their interactions with other molecules at the level of individual amino acids. Using currently available peptide synthesis methods, sequentially continu...

journal_title：Protein and peptide letters

authors： Eichler J

更新日期：2004-08-01 00:00:00

abstract：:Background. Obesity is a major health problem in both developed and emerging countries. Obesity is a complex disease whose etiology involves genetic factors in strong interplay with environmental determinants and lifestyle. The discovery of genetic factors and biological pathways underlying human obesity is hampered b...

journal_title：Protein and peptide letters

authors： Martelli PL,Fontanesi L,Piovesan D,Fariselli P,Casadio R

更新日期：2014-01-01 00:00:00

abstract：:To achieve the food-grade expression of bile salt hydrolase (BSH, EC 3.5.1.24) from Lactobacillus plantarum BBE7, the nisin controlled gene expression system (NICE), food-grade selection maker and signal peptide of Lactococcus lactis were used in this study. The open reading frame of BSH was optimized based on the cod...

journal_title：Protein and peptide letters

authors： Dong Z,Zhang J,Li H,Du G,Chen J,Lee B

更新日期：2015-01-01 00:00:00

abstract：:Saturation Transfer Difference NMR (STD NMR) is used for the detection of the binding constant of the decapeptide RRRDDDSDDD with CK2α, the catalytic subunit of the proteinkinase CK2. For this work a valid irradiation frequency of the CK2α had to be found ensuring that no peptide resonance is affected by the irradiati...

journal_title：Protein and peptide letters

authors： Raüber C,Berger S

更新日期：2012-09-01 00:00:00

abstract：:We report that the plant oncoprotein RolA from Agrobacterium rhizogenes acts to stabilize beta-glucoronidase (Gus) when the two proteins are expressed as a fusion protein in transformed tobacco. The observed 50-fold increase of Gus activity was shown to be related to protein accumulation, with no significant changes i...

journal_title：Protein and peptide letters

authors： Barros LM,Curtis RH,Viana AA,Campos L,Carneiro M

更新日期：2003-06-01 00:00:00

abstract：:Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...

journal_title：Protein and peptide letters

authors： Wang X,Wang D,Zhao J,Qu M,Zhou X,He H,He R

更新日期：2006-01-01 00:00:00

abstract：:In 2008 cancer was identified by the World Health Organization (WHO) as one of four threats to human health and development. Since the early published reports of the first chemotherapeutic, mustine, in 1946, the anti-cancer drug and development industry has grown into a multi-billion dollar business enterprise. Worldw...

journal_title：Protein and peptide letters

authors： Li Q,Yi L,Marek P

更新日期：2014-01-01 00:00:00

abstract：:A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further syn...

journal_title：Protein and peptide letters

authors： Hanna-Elias A,Thompson PE,Manallack DT,Irving HR,Coupar IM,Berque-Bestel I,Iskander MN

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Peptide: N-glycanase is a deglycosylation enzyme releasing N-glycan from glycoproteins. Although glycan specificity analysis of this enzyme has been reported, recognition requirements for the peptide sequence have not been precisely elucidated. OBJECTIVE:In this study, we carried out peptide specificity ana...

journal_title：Protein and peptide letters

authors： Kuribara T,Ishihara T,Kudo T,Hirano M,Totani K

更新日期：2017-01-01 00:00:00

abstract：:Most proteinaceous pores are characterized as ionic channels. However, some are also involved in protein translocation through phospholipidic membranes. This concept has evolved slowly in cell biology and in biophysics, requiring the development of adapted electrical and biochemical methods. Protein translocation in m...

journal_title：Protein and peptide letters

authors： Henry JP

更新日期：2014-03-01 00:00:00

abstract：:Catalase is an enzyme that occurs in almost all aerobic organisms. Its main metabolic function is to prevent oxidative damage to tissues induced by hydrogen peroxide which is a strong oxidizing agent. Catalase is very effective in performing this task, since it has the highest turnover rate among all the enzymes. The ...

journal_title：Protein and peptide letters

authors： Seixas FA,da Silva MR,Murakami MT,Tosqui P,Colombo MF

更新日期：2011-09-01 00:00:00

abstract：:A new coding sequence of the procarboxypeptidase B gene was obtained from SD rat fresh pancreas by RT-PCR and highly expressed in Escherichia coli in inclusion bodies. The folded procarboxypeptidase B was subjected to trypsin enzymatic cleavage to produce active carboxypeptidase B, subsequently, carboxypeptidase B was...

journal_title：Protein and peptide letters

authors： Su-Xia L,Yu-Jian Z,Li-Ping T,Qin-Sheng Y,Yi G

更新日期：2003-12-01 00:00:00

abstract：:Protein phosphatase magnesium-dependent 1, delta (PPM1D) is a member of the PPM1 (formerly PP2C) protein phosphatase family, and is induced in response to DNA damage. The overexpression of PPM1D is thought to exert oncogenic effects through the inhibition of tumor suppressor proteins. PPM1D shows high selectivity for ...

journal_title：Protein and peptide letters

authors： Chuman Y,Yagi H,Fukuda T,Nomura T,Matsukizono M,Shimohigashi Y,Sakaguchi K

更新日期：2008-01-01 00:00:00

abstract：:During spermiogenesis, the elongating rat spermatid chromatin undergoes a gradual process of condensation which is initiated in the round spermatids at "step 7" of cytodifferentation in stage VII and extending to elongated spermatids at "step 19" of cytodifferentiation in stage VIII. The mechanism of chromatin condens...

journal_title：Protein and peptide letters

authors： Gill-Sharma MK,Choudhuri J,D'Souza S

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The biocatalytic oxidation of UDP-glucose in the presence of NAD+ is catalyzed by UDP-glucose dehydrogenases. OBJECTIVES:The main objective of this study was the characterization of a UDP-glucose dehydrogenase (AmUGD) from Akkermansia muciniphila, a bacterium originally isolated from human faeces in an anae...

journal_title：Protein and peptide letters

authors： Wei S,Zhang XY,Sun Y,Conway LP,Liu L

更新日期：2017-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) constitute an important alternative in the search for new treatments against pathogens. We analyzed the sequence variability in cytokine and chemokine proteins to investigate whether these molecules contain a sequence useful in the development of new AMPs. Cluster analysis allowed the ide...

journal_title：Protein and peptide letters

authors： Robles-Gomez EE,Flores-Villegas MC,Gonzalez-Manjarrez A,Soriano-Garcia M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...

journal_title：Protein and peptide letters

authors： Chukhontseva KN,Salnikov VV,Morenkov OS,Kostrov SV,Demidyuk IV

更新日期：2019-01-01 00:00:00

abstract：:The etiology of multiple sclerosis (MS) remains unclear. To determine if autoantibodies to myelin basic protein (MBP) are produced during parvovirus B19 infection, a competitive ELISA was performed using plasma from MS patients exhibiting high IgG titers for parvovirus. Our results showed the addition of MBP decreased...

journal_title：Protein and peptide letters

authors： Thomas G,Rael L,Shimonkevitz R,Melamed I,Bar-Or D

更新日期：2006-01-01 00:00:00

abstract：:The aerotolerance of the lactic - fermentative bacterium Streptococcus thermophilus is mainly based on the key antioxidant function of superoxide dismutase (StSOD). In this work, the comparison of recombinant StSOD (rStSOD) forms obtained from two different initiation triplets indicated that the enzyme from S. thermop...

journal_title：Protein and peptide letters

authors： De Vendittis A,Marco S,Di Maro A,Chambery A,Albino A,Masullo M,Michniewicz A,Parlato G,De Angelis A,De Vendittis E,Rullo R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Protein-carbohydrate interactions play vital roles in several biological processes in living organisms. The comparative analysis of binding site residues along with stabilizing residues in protein-carbohydrate complexes provides ample insights to understand the structure, function and recognition mechanism. ...

journal_title：Protein and peptide letters

authors： Shanmugam NRS,Selvin JFA,Veluraja K,Gromiha MM

更新日期：2018-01-01 00:00:00

abstract：:Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may be a good target f...

journal_title：Protein and peptide letters

authors： Janka L,Clemente J,Vaiana N,Sparatore A,Romeo S,Dunn BM

更新日期：2008-01-01 00:00:00

abstract：:The formation of amyloid-like fibrils was studied by using the well-known serine protease trypsin as a model protein in the presence of ethanol as organic solvent. Trypsin forms amyloid-like fibrils in aqueous ethanol at pH = 7.0. The dye Congo red (CR) was used to detect the presence of amyloid-like fibrils in the sa...

journal_title：Protein and peptide letters

authors： Kotormán M,Simon ML,Borics A,Szabó MR,Szabó K,Szögi T,Fülöp L

更新日期：2015-01-01 00:00:00

abstract：:A novel cellulase was isolated from the thermoacidophilic bacterium Alicyclobacillus acidocaldarius ATCC27009 grown in medium containing carboxymethylcellulose. The enzyme is a glycosylated monomer of 56.2 kDa, relatively thermostable, with optimal pH and temperature of 4.0 and 65 degrees C, respectively. Enzymatic as...

journal_title：Protein and peptide letters

authors： Morana A,Esposito A,Maurelli L,Ruggiero G,Ionata E,Rossi M,La Cara F

更新日期：2008-01-01 00:00:00

abstract：:Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus and bovine heart, respectively. Initial studies demonstrated that PNX is a rep...

journal_title：Protein and peptide letters

authors： Yuan T,Sun Z,Zhao W,Wang T,Zhang J,Niu D

更新日期：2017-01-01 00:00:00

abstract：:Hop is a tetratricopeptide repeat domain (TPR)-containing co-chaperone that is able to directly associate with both Hsp70 and Hsp90. Previous data showed that the TPR2A-domain is the primary site for dimerization and that the TPR2B-domain may also play a role in dimerization. We present Hop-D456G, a mutant within the ...

journal_title：Protein and peptide letters

authors： Gonçalves DC,Gava LM,Ramos CH

更新日期：2010-04-01 00:00:00

abstract：:We present the results of a study on the influence of albumin and prolactin concentrations and intravascular fluid pH on vein permeability for albumin. Permeability conditions were simulated depending on albumin concentration, pH value and prolactin concentration. In research model an in vitro method was applied using...

journal_title：Protein and peptide letters

authors： Dolińska B,Caban A,Cierpka L,Ryszka F

更新日期：2014-01-01 00:00:00

abstract：:Cationic antimicrobial peptides (AMPs) are among the best studied antimicrobial factors expressed in the respiratory tract. AMPs are released by epithelial cells and immune cells into the airway surface liquid covering the epithelial surfaces of the lung where they act as endogenous antibiotics. Plenty of studies show...

journal_title：Protein and peptide letters

authors： Seiler F,Lepper PM,Bals R,Beisswenger C

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...

journal_title：Protein and peptide letters

authors： Francisco CC,Luis CJ,Marina EJ,Javier CF,Alexis LA,Del Carmen SH,Alfredo RI

更新日期：2019-01-01 00:00:00

abstract：:The immunoglobulin fold (Ig-fold) is a widespread structural motif that is detected in a variety of proteins involved in diversified biological processes. The Ig-fold contains 70-110 residues that are assembled in a characteristic sandwich-like structure formed by two facing β-sheets each made of antiparallel β-strand...

journal_title：Protein and peptide letters

authors： Berisio R,Ciccarelli L,Squeglia F,De Simone A,Vitagliano L

更新日期：2012-10-01 00:00:00