Abstract:
:Phoenixin (PNX), a newly identified peptide cleaved from the C-terminus of protein C4orf52, mainly exists in two active isoforms, phoenixin-14 (PNX-14) amide and phoenixin-20 (PNX-20) amide that were first isolated from the rat hypothalamus and bovine heart, respectively. Initial studies demonstrated that PNX is a reproductive peptide, which affects the hypothalamus pituitary genital (HPG) axis through regulating the expression of kisspeptin, GnRH, GnRH receptor, LH and oestrus process. However, further studies indicated that PNX might play a wide range of roles in additional physiological process such as inhibiting visceral pain and eliciting pruritus, inducing anxiety, improving memory retention. Recently, Gpr173, also designated as SREB3, was identified as the cognate receptor of PNX. Whereas, the regulatory mechanism of PNX has not been fully clarified. This review aims to provide the current knowledge of PNX and propose some study directions for future research.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Yuan T,Sun Z,Zhao W,Wang T,Zhang J,Niu Ddoi
10.2174/0929866524666170207154417subject
Has Abstractpub_date
2017-01-01 00:00:00pages
472-475issue
6eissn
0929-8665issn
1875-5305pii
PPL-EPUB-81603journal_volume
24pub_type
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