Abstract:
:Rheumatoid arthritis (RA) is a chronic disease with an autoimmunological background. RA is mostly characterized by systemic inflammation and injuries of synovial joints. There is a hypothesis that bacterial infections may be connected with development of the disease. It has been suggested that molecular mimicry between bacterial and human antigens may be one of possible mechanisms of RA development. One of potential antigens involved in this mechanism is urease - enzyme with high structural conservatism, occurring in pathogenic and commensal bacteria. We found that the level of antibodies against peptide mimicking urease "flap" region is significantly higher in sera from patients with rheumatoid arthritis in comparison with volunteer blood donor sera. We also observed that antibodies present in RA sera may bind not only specific peptide antigens but also peptides with a slightly different structure.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Konieczna I,Kwinkowski M,Kolesińska B,Kamiński Z,Zarnowiec P,Kaca Wdoi
10.2174/092986612803217123subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1149-54issue
11eissn
0929-8665issn
1875-5305pii
PPL-EPUB-20120508-001journal_volume
19pub_type
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