Abstract:
:The role of interaction between Asn259 (catalytic domain) with Gln821 (C-terminal domain) in PeptidaseN was investigated. The k(cat) of PeptidaseN containing Asn259Asp or Gln821Glu is enhanced whereas it is suppressed in Asn259AspGln821Glu. Structural analysis shows this interaction to change the relative disposition of active site residues, which modulates catalytic activity.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Kumar A,Reddy S,Srinivasan N,Nandi Ddoi
10.2174/092986609787848081subject
Has Abstractpub_date
2009-01-01 00:00:00pages
415-22issue
4eissn
0929-8665issn
1875-5305journal_volume
16pub_type
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