Irbesartan inhibits albumin-elicited proximal tubular cell apoptosis and injury in vitro.

abstract：:Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...

journal_title：Protein and peptide letters

authors： Rajendran SR,Ejike CE,Gong M,Hannah W,Udenigwe CC

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Reversibly glycosylated polypeptide (RGP), a kind of hydrosoluble and plasmodesmal-associated protein found in plants, plays a crucial role in the development of pollen. OBJECTIVE:A novel RGP 2 was isolated and identified from rape (Brassica napus L.) bee pollen. METHOD:RGP2 was isolated and purified by io...

journal_title：Protein and peptide letters

authors： Zhang Q,Sun T,Tuo X,Li Y,Yang H,Deng J

更新日期：2020-11-03 00:00:00

abstract：:A Surface Plasmon Resonance Imaging (SPRI) sensor has been developed for highly selective determination of cathepsin D (Cat D) or/and E (Cat E). The sensor contains immobilised pepstatin A, which binds aspartyl proteases from solution. Pepstatin A activated with N-Hydroxysuccinimide (NHS) and N-Ethyl-N'-(3-dimethylami...

journal_title：Protein and peptide letters

authors： Gorodkiewicz E,Regulska E

更新日期：2010-09-01 00:00:00

abstract：:We present two efficient network propagation algorithms that operate on a binary tree, i.e., a sparse-edged substitute of an entire similarity network. TreeProp-N is based on passing increments between nodes while TreeProp-E employs propagation to the edges of the tree. Both algorithms improve protein classification e...

journal_title：Protein and peptide letters

authors： Kocsor A,Busa-Fekete R,Pongor S

更新日期：2008-01-01 00:00:00

abstract：:Classification of newly determined protein structures is important in understanding their function and mechanism of action. Currently available methods employ a global structure alignment strategy and are computationally expensive. We propose a two-step methodology with a quick screen to significantly reduce the numbe...

journal_title：Protein and peptide letters

authors： Dalal A,Deshmukh S,Wangika PP

更新日期：2007-01-01 00:00:00

abstract：:The small heat shock protein SsHSP14.1 from the hyper-thermophilic archeaon, Sulfolobus solfataricus (S. solfataricus) was able to protect proteins from thermal aggregation and prevent enzymes from heat induced inactivation. According to the 3D (dimensional) structural model of SsHSP14.1 developed by us before, the re...

journal_title：Protein and peptide letters

authors： Wen ZZ,Wang YH,Yang B,Xie MQ,Chou KC

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Radical Probe Mass Spectrometry (RP-MS) describes a pioneering methodology in structural biology that enables the study of protein structures, their interactions, and dynamics on fast timescales (down to sub-milliseconds). Hydroxyl radicals (•OH) generated directly from water within aqueous solutions induce ...

journal_title：Protein and peptide letters

authors： Maleknia SD,Downard KM

更新日期：2019-01-01 00:00:00

abstract：:F(0)F(1)-ATPase is a rotary molecular motor. It is well known that the rotary torque is generated by ATP hydrolysis in F(1) but little is known about how it produces the proton-motive force (PMF) in F(0). Here a cross-linking approach was used to estimate the rotary torque produced by PMF. Three mutant E. coli strains...

journal_title：Protein and peptide letters

authors： Liu X,Cui Y,Chen C,Lai B,Yue J,Zhang Z

更新日期：2007-01-01 00:00:00

abstract：:Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...

journal_title：Protein and peptide letters

authors： Chen Y,Tao K,Ji W,Makam P,Rencus-Lazar S,Gazit E

更新日期：2020-01-01 00:00:00

abstract：:Michael Laskowski Jr. (1930-2004) was a pioneer in the field of Standard mechanism serine proteinase inhibitors. He made numerous important contributions in the field. This article highlights some of his most important contributions such as the discovery of the reactive site in serine proteinase inhibitors, the propos...

journal_title：Protein and peptide letters

authors： Qasim MA

更新日期：2005-07-01 00:00:00

abstract：:Human butyrylcholinesterase (BuChE) is a serine enzyme present in most organs and plasma. No clear physiological function has yet been assigned to BuChE, but it is a pharmacologically and toxicologically important enzyme that plays a role in degradation of numerous ester-containing drugs and poisonous esters. Thus, Bu...

journal_title：Protein and peptide letters

authors： Masson P,Carletti E,Nachon F

更新日期：2009-01-01 00:00:00

abstract：:Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...

journal_title：Protein and peptide letters

authors： Qi X,Wang J,Meng Q,Liu XQ

更新日期：2011-12-01 00:00:00

abstract：:The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and car...

journal_title：Protein and peptide letters

authors： Rein J,Bader M

更新日期：2017-11-17 00:00:00

abstract：BACKGROUND:Uterine Leiomyoma is mainly widespread non-malignant tumor. Around more than 80% woman have these particular tumor among them only 30% of them are detected. Integrin-ᵦ1 is one of the up regulated biomarkers during tumorigenesis which is also associated with structural disordered. Intrinsically disordered pro...

journal_title：Protein and peptide letters

authors： Maulik U,Uversky VN,Sen S

更新日期：2018-01-01 00:00:00

abstract：:Human histatins are histidine-rich, low molecular weight salivary proteins that contribute to the immune system of the oral cavity. In this work, nucleotide sequences of the HIS1 (coding for histatin 1) and HIS2 (coding for histatin 3) genes, homologous to the human ones, have been sequenced and analysed in five prima...

journal_title：Protein and peptide letters

authors： Padovan L,Segat L,Pontillo A,Antcheva N,Tossi A,Crovella S

更新日期：2010-07-01 00:00:00

abstract：:The outcome of protein crystallization attempts is often uncertain due to inherent features of the protein or to the crystallization process that are not fully under control of the experimentalist. The aim of this contribution is to propose user-friendly tools that can increase the success rate of a protein crytalliza...

journal_title：Protein and peptide letters

authors： Sánchez-Puig N,Sauter C,Lorber B,Giegé R,Moreno A

更新日期：2012-07-01 00:00:00

abstract：:Sry-related box (Sox) transcription factors share a conserved high-mobility-group box domain (HMG-domain) that binds DNA in the minor groove and bends DNA for further assembly of transcriptional machineries. During organogenesis, each member of the Sox family triggers a specific cell lineage differentiation, indicatin...

journal_title：Protein and peptide letters

authors： Gao N,Jiang W,Gao H,Cheng Z,Qian H,Si S,Xie Y

更新日期：2013-04-01 00:00:00

abstract：:Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better un...

journal_title：Protein and peptide letters

authors： Nayeem MS,Khan RH

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...

journal_title：Protein and peptide letters

authors： Francisco CC,Luis CJ,Marina EJ,Javier CF,Alexis LA,Del Carmen SH,Alfredo RI

更新日期：2019-01-01 00:00:00

abstract：:The aim of this study was to design and develop stable nanoemulsion formulations containing IFN-γ to probe their use as an immunomodulating agent. The nanoemulsions comprising distilled water, triglycerides of capric acid/caprylic, sobitan-oleate (SP), polysorbate 80 (TW) and propylene glycol (PG) were prepared throug...

journal_title：Protein and peptide letters

authors： Ribeiro EB,Honorio-França AC,França EL,Soler MA

更新日期：2016-01-01 00:00:00

abstract：:This study revealed that the content of protein S29 in ribosomes of cancer cell line A549 was distinctly low (equivalent to about 30% of that of 2BS). The conclusion was acquired based on the ratios of spot volume of ribosomal protein S29 to that of several other ribosomal proteins (S29/L37a, S29/L38, S29/S27 and S29/...

journal_title：Protein and peptide letters

authors： Zhou ZD,Bao L,Liu DG,Li MQ,Ge YZ,Huang YL,Liu WY

更新日期：2003-02-01 00:00:00

abstract：:Numerous small molecules including cytokines primarily associated with immune response have been shown to play a role in normal mesenchymal stem cells (MSC) and tumour cells' communication. One characteristic that distinguishes MSC from fibroblast and other cells of mesenchymal origin is their pro-tumour migratory beh...

journal_title：Protein and peptide letters

authors： Motaln H,Turnsek TL

更新日期：2015-01-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known to interact with different biomolecules and was implicated in many novel cellular activities including programmed cell death, nuclear RNA transport unrelated to the commonly known carbohydrate metabolism. We reported here the purification of GAPDH from Chironom...

journal_title：Protein and peptide letters

authors： Chong IK,Ho WS

更新日期：2013-09-01 00:00:00

abstract：:DrTI was effective against trypsin-like enzymes from A. kuehniella and C. cephalonica, however an artificial diet was insufficient to affect the survival and body weight of either insect. The inhibitor stimulated chymotrypsin-like enzymes and probably induced the synthesis of enzymes insensitive to TLCK in neonate lar...

journal_title：Protein and peptide letters

authors： Macedo ML,Pando SC,Chevreuil LR,Marangoni S

更新日期：2009-01-01 00:00:00

abstract：:Arginine kinase is an essential enzyme which is closely related to energy metabolism in marine invertebrates. Arginine kinase provides a significant role in quick response to environmental change and stress. In this study, we simulated a tertiary structure of Sepia pharaonis arginine kinase (SPAK) based on the gene se...

journal_title：Protein and peptide letters

authors： Si YX,Lee J,Cheng JG,Yin SJ,Park YD,Qian GY,Jiang XM

更新日期：2016-01-01 00:00:00

abstract：:A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further syn...

journal_title：Protein and peptide letters

authors： Hanna-Elias A,Thompson PE,Manallack DT,Irving HR,Coupar IM,Berque-Bestel I,Iskander MN

更新日期：2009-01-01 00:00:00

abstract：:A proof-of-principle methodology is presented in which all commercially-available cysteine (Cys) and selenocysteine (Sec) solid phase peptide synthesis (SPPS) derivatives are synthesized in high yield from easily prepared protected dichalcogenide precursors. A Zn-mediated biphasic reduction process applied to a series...

journal_title：Protein and peptide letters

authors： Flemer S

更新日期：2014-01-01 00:00:00

abstract：:DNA fragmentation factor 45 (DFF45) regulates DNase DFF40 as its inhibitor and chaperone. It was reported that the N-terminal domain (NTD) of DFF45 alone is disordered and DFF40 is necessary as a mutual chaperone for the folding of NTD. However, here we reported the crystallization of DFF45 NTD. These crystals diffrac...

journal_title：Protein and peptide letters

authors： Li T,Li X,Yang W,Rao Z,Zhai Zh

更新日期：2003-04-01 00:00:00

abstract：:Porcine β defensin 2(pBD2)is a cationic 37-amino acid antimicrobial peptide with disulfide bonds. Synthetic pBD2 had broad antimicrobial activity against pathogenic bacteria, and thus pBD2 could be a good candidate as a bactericidal agent for pigs. This study reported the successful recombinant expression of pBD2 in E...

journal_title：Protein and peptide letters

authors： Li CL,Zhao YC,Song XY,Huang XX,Zhao WD

更新日期：2013-06-01 00:00:00

abstract：:Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur. ...

journal_title：Protein and peptide letters

authors： Shiraishi N,Inai Y,Ihara Y

更新日期：2009-01-01 00:00:00