Abstract:
:There is a growing body of evidence that the formation and accumulation of advanced glycation end products (AGE) have been known to progress under diabetic conditions, thereby being involved in diabetic vascular complications. Further, we, along with others, have recently found AGE could disturb insulin actions in cultured adipocytes and skeletal muscles. However, the pathological role of AGE in insulin resistance in vivo is not fully understood. Therefore, in this study, we examined whether pyridoxamine, an inhibitor of AGE formation could ameliorate insulin resistance in KK-A(y) mice, a model animal of obese, type 2 diabetes. Fasting blood glucose, serum levels of insulin and AGE in KK-A(y) mice were elevated as the mice got older (from 5 weeks old to 15 weeks old). Serum levels of AGE were positively correlated with insulin (R(2)=0.3956, P=0.002) in KK-A(y) mice. Administration of pyridoxamine dose-dependently decreased fasting insulin levels and improved insulin sensitivity in KK-A(y) mice of 10 weeks old, although it did not affect fasting blood glucose levels. Our present study suggests the involvement of AGE in insulin resistance in KK-A(y) mice. Inhibition of AGE formation may be a novel therapeutic target for improving insulin resistance in diabetes with obesity.
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Unoki-Kubota H,Yamagishi S,Takeuchi M,Bujo H,Saito Ydoi
10.2174/092986610791760423subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1177-81issue
9eissn
0929-8665issn
1875-5305pii
BSP/ PPL/ E pub/0151journal_volume
17pub_type
杂志文章abstract::To identify proteins involved in the molecular mechanisms of pressure overload-induced heart failure, we quantitatively analyzed the left ventricular proteomic profile in a transverse aortic constriction (TAC) mouse model, a well-established model of cardiac hypertrophy and dysfunction. Multidimensional LC-MS/MS in co...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666151125231747
更新日期:2016-01-01 00:00:00
abstract::Spermadhesins are a family of secretory proteins expressed in the male genital tract of pig, horse and bull. Their function and structure have been widely studied, especially those isolated from boar. However, there are no data concerning spermadhesins isolated from buck. Buck seminal plasma was collected and subjecte...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408670
更新日期:2002-08-01 00:00:00
abstract::Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide syn...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791306625
更新日期:2010-07-01 00:00:00
abstract::Retro-ACP (74-65) fragment was synthesized on a novel 4% tri-(propylene glycol) glycerolate diacrylate cross-linked polystyrene (PS-TRPGGDA) support. The peptide is grown from the functional site present in the cross-linker, which makes it unique and cost-effective among other styrene based polymer supports. A compara...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866033478753
更新日期:2003-10-01 00:00:00
abstract::Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in ce...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777790566
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:NMAAP1 plays a role in regulating macrophage differentiation to the M1 type and exerting antitumoral functions. It is not clear what role and mechanism NMAAP1 does play in the reversal of macrophages from M1 to M2. METHODS:We detected the typing of macrophages with high or low expression of NMAAP1 by QPCR a...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190503105343
更新日期:2019-01-01 00:00:00
abstract::Saturation Transfer Difference NMR (STD NMR) is used for the detection of the binding constant of the decapeptide RRRDDDSDDD with CK2α, the catalytic subunit of the proteinkinase CK2. For this work a valid irradiation frequency of the CK2α had to be found ensuring that no peptide resonance is affected by the irradiati...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612802084447
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:The Renin-Angiotensin System (RAS) has emerged as being related to vascular disease. Recently the RAS has been associated with obesity, diabetes, and even cancer. OBJECTIVE:This review and Bioinformatics analyses focuses on the investigation of Angiotensinconverting enzymes (ACE and ACE2) as therapeutical...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170815161621
更新日期:2017-11-17 00:00:00
abstract::We present the results of a study on the influence of albumin and prolactin concentrations and intravascular fluid pH on vein permeability for albumin. Permeability conditions were simulated depending on albumin concentration, pH value and prolactin concentration. In research model an in vitro method was applied using...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113209990082
更新日期:2014-01-01 00:00:00
abstract::The physiological stability curve--a plot of the free energy of unfolding versus temperature--is calculated for hen egg white lysozyme from a combination of extrapolated unfolding thermodynamic data from reversible conditions and isothermal titrations with guanidine hydrochloride. The shape of the curve suggests the e...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777841163
更新日期:2006-01-01 00:00:00
abstract::Sexual maturation and olfactory bulb defects found in prokineticin 2 (Pk2) and prokineticin receptor 2 (Pkr2) mutant mice resembling the phenotypic characteristics of Kallmann syndrome (KS), gave rise to the question of whether these genes would have a role in KS pathogenesis. Later, mutations in both genes were ident...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866523666160517123331
更新日期:2016-01-01 00:00:00
abstract::The identification of interfaces in protein complexes is effective for the elucidation of protein function and helps us to understand their roles in biological processes. With the exponentially growing amount of protein sequence data, an exploration of new methods that predict protein interaction sites based solely on...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986613804725208
更新日期:2013-02-01 00:00:00
abstract::The formation of local structure, in short peptides has been probed by examining cleavage patterns and rates of proteolysis of designed sequences with a high tendency to form beta-hairpin structures. Three model sequences which bear fluorescence donor and acceptor groups have been investigated: [see text]. Fluorescenc...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606776819501
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171221114658
更新日期:2018-01-01 00:00:00
abstract::A missense mutation of Aspartic to Asparagine acid in 113 position of liver-targeting peptide CSP I-plus modified rEndostatin (rES-CSP) happened unexpectedly results in the changes of protein secondary structure and a reduced bioactivity. With the aim to clarify the structure-function relationships featuring the fuse ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150302125218
更新日期:2015-01-01 00:00:00
abstract::The development of a stable L-BDH chimera was attempted by exchanging whole domains between two native structural analogs, L-BDH and meso-BDH, because the S-configuration specificity of L-BDH is valuable from the standpoint of its application but its activity is unstable, whereas meso-BDH is stable. The domain chimera...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795713970
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Type VI Secretion System (T6SS) has been found in approximately onequarter of the gram-negative bacterial species, and its structural characteristics appear to slightly differ from species to species. The genes encoding T6SS are designated as type six secretion A-M (tssA-M). The expression of the tss gene cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190119121859
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Cathepsin D is a lysosomal enzyme that is found in all organisms acting in protein turnover, in humans it is present in some types of carcinomas, and it has a high activity in Parkinson's disease and a low activity in Alzheimer disease. In marine organisms, most of the research has been limited to corroborat...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666190405124353
更新日期:2019-01-01 00:00:00
abstract::VML is a lectin from Vatairea macrocarpa seeds that has various biological activities. Here, we describe three new lectin isoforms from V. macrocarpa identified through genomic DNA analysis. One of these isoforms has high similarity to VML, while another that has noteworthy differences. We have denoted the new isoform...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/09298665113209990049
更新日期:2013-11-01 00:00:00
abstract::The prediction of protein function is a difficult and important problem in computational biology. In this study, an efficient method is presented to predict protein function with sequence composition information. Four kinds of basic building blocks of protein sequences are investigated, including N-grams, binary profi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791190336
更新日期:2010-06-01 00:00:00
abstract::Currently, prion phenomena have been detected in various organisms, in addition to mammals affected by transmissible spongiform encephalopathies. In the budding yeast Saccharomyces cerevisiae, various proteins have prion properties and adopt atypical phenotypes as genetic elements, such as the Sup35 and Ure2 proteins,...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609787601796
更新日期:2009-01-01 00:00:00
abstract::Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788681724
更新日期:2009-01-01 00:00:00
abstract::S-adenosyl-l-homocysteine hydrolase from a malaria parasite Plasmodium falciparum (PfSAHH) has been crystallized by the vapor diffusion method. The crystals belong to an orthorhombic space group P212121 with the cell dimensions of a = 76.66 A, b = 86.31 A, and c = 335.6 A. There are four subunits (one tetramer) per as...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866043478248
更新日期:2004-04-01 00:00:00
abstract::The study of rat proteins is an indispensable task in experimental medicine and drug development. The function of a rat protein is closely related to its subcellular location. Based on the above concept, we construct the benchmark rat proteins dataset and develop a combined approach for predicting the subcellular loca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795222768
更新日期:2011-06-01 00:00:00
abstract::Natural, synthetic and analogues of peptides have shown prospects for application in cancer chemotherapy. Notably, some food protein-derived peptides are known to possess anticancer activities in cultured cancer cells, and also in animal cancer models via different mechanisms including induction of apoptosis, cell cyc...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866523666160816152755
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Cryptochrome is a flavin-binding blue-light photoreceptor that functions in growth and development in plants, the circadian clock in animals and navigation in birds. However, a lack of purified cryptochrome has hindered studies of the structure and function of this protein. In this study, we obtained a subst...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666181004112308
更新日期:2018-01-01 00:00:00
abstract::Supramolecular self-assembled functional materials comprised of cyclic dipeptide building blocks have excellent prospects for biotechnology applications due to their exceptional structural rigidity, morphological flexibility, ease of preparation and modification. Although the pharmacological uses of many natural cycli...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866527666200212123542
更新日期:2020-01-01 00:00:00
abstract::With a huge amount of protein sequence data, the computational method for protein-protein interaction (PPI) prediction using only the protein sequences information have drawn increasing interest. In this article, we propose a sequence-based method based on a novel representation of local protein sequence descriptors. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610791760306
更新日期:2010-09-01 00:00:00
abstract::Since their recent identification, eukaryotic Hsp70 nucleotide exchange factors (NEFs) have gained increasing interest due to their engagement in vital cellular processes. Here, I summarize our current knowledge of their mechanisms of action, regulations and cellular functions as well as their relevance for human dise...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986609788490186
更新日期:2009-01-01 00:00:00
abstract::The mutation, conferring streptomycin and deoxyglucose resistance on cells, had profound effect on the kinetic and thermodynamic parameters inferring thermostabilization of beta-glucosidase from mutant 51 SM(r) of Cellulomonas biazotea. Free energy of activation for substrate binding, enthalpy and entropy of activatio...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866053587183
更新日期:2005-04-01 00:00:00