Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors.

Abstract:

:Plasmepsin 4 (PM4) is a digestive vacuole enzyme found in all Plasmodium species examined to date. While P. falciparum has three additional aspartic proteinases in its digestive vacuole in addition to plasmepsin 4, other Plasmodium species have only PM4 in their digestive vacuole. Therefore, PM4 may be a good target for the development of an antimalarial drug. This study presents data obtained with PM4s from several Plasmodium species. Low nanomolar K(i) values have been observed for all PM4s studied.

journal_name

Protein Pept Lett

authors

Janka L,Clemente J,Vaiana N,Sparatore A,Romeo S,Dunn BM

doi

10.2174/092986608785849218

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

868-73

issue

9

eissn

0929-8665

issn

1875-5305

journal_volume

15

pub_type

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