Abstract:
:Hepatitis C virus and related viruses in the Flaviviridae family (such as dengue virus, yellow fever virus or West Nile virus) are amongst the most important human pathogens, causing substantial morbidity and mortality world-wide. The production of viral progeny in Flaviviridae is orchestrated by the small, multifunctional core protein, which coats and condenses the viral genomic RNA during Nucleocapsid formation. In addition to their structural role, mounting experimental evidence links core proteins to viral persistence and pathogenesis, by virtue of their promiscuous interactions with host cell factors. In this review, we summarize the present knowledge about the structure of Flaviviridae core proteins and discuss the importance of flexible, intrinsically unstructured protein regions in viral assembly and hub formation in the virus-host protein-protein interaction network (infection network).
journal_name
Protein Pept Lettjournal_title
Protein and peptide lettersauthors
Ivanyi-Nagy R,Darlix JLdoi
10.2174/092986610791498911subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1019-25issue
8eissn
0929-8665issn
1875-5305pii
BSP/ PPL/ E pub/0161journal_volume
17pub_type
杂志文章,评审abstract::The study of rat proteins is an indispensable task in experimental medicine and drug development. The function of a rat protein is closely related to its subcellular location. Based on the above concept, we construct the benchmark rat proteins dataset and develop a combined approach for predicting the subcellular loca...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795222768
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Hepatitis C Virus (HCV) is a major cause of chronic liver disease in the world. Many studies showed that T-cell responses to HCV Nonstructural Protein 3 (NS3) play an important role in clearing acute HCV infections, thus NS3 can be considered as a suitable candidate antigen for development of a HCV therapeut...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666180925145304
更新日期:2018-01-01 00:00:00
abstract::Nicotinamide adenine dinucleotide (NAD) plays an important role in cellular metabolism and acts as hydrideaccepting and hydride-donating coenzymes in energy production. Identification of NAD protein interacting sites can significantly aid in understanding the NAD dependent metabolism and pathways, and it could further...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612800191017
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Development of proteins and peptides into drugs has been considered as a promising strategy to target certain diseases. However, only few proteins and peptides have been approved as new drugs into the market each year. One major problem is that proteins and peptides often exhibit short plasma half-life times...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180530122835
更新日期:2018-01-01 00:00:00
abstract::We examined the production and secretion of fusion constructs containing alpha-N-acetylglucosaminidase, the enzyme deficient in Sanfilippo B, and either wildtype TAT or modified TAT in cultured Spodoptera frugiperda cells. All constructs exhibited successful expression of active enzyme, suggesting the future possibili...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606775974456
更新日期:2006-01-01 00:00:00
abstract::Though protein folding is a regular phenomenon inside the cellular milieu, slight differences in the folding pattern of proteins may lead to disease-causing forms. Many diseases have been identified that are caused by these misfolded macromolecules and a considerable amount of focus is still directed towards better un...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866043406409
更新日期:2004-12-01 00:00:00
abstract::Mastoparans are tetradecapeptides found to be the major component of wasp venoms. These peptides possess a variety of biological activities. Three related mastoparans, mastoparan from Polistes jadwagae (MP-PJ), mastoparanX (MP-X) and its carboxyl-free C-terminal form (MP-X-COO-), were crystallized. X-ray diffraction d...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986606777145896
更新日期:2006-01-01 00:00:00
abstract::Polymyositis is an inflammatory myopathy characterized by muscle invasion of T-cells penetrating the basal lamina and displacing the plasma membrane of normal muscle fibers. In order to understand the different adhesive mechanisms at the T-cell surface, Schubert randomly selected 19 proteins expressed at the T-cell su...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986612801619534
更新日期:2012-08-01 00:00:00
abstract::Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known to interact with different biomolecules and was implicated in many novel cellular activities including programmed cell death, nuclear RNA transport unrelated to the commonly known carbohydrate metabolism. We reported here the purification of GAPDH from Chironom...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320090002
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:A core sequence (the 9 C-terminal residues) of calcification-associated peptide (CAP- 1) isolated from the exoskeleton of the red swamp crayfish was previously shown to control calcium carbonate precipitation with chitin. In addition, a modified core sequence in which the phosphorylated serine at the N termi...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866525666171221114658
更新日期:2018-01-01 00:00:00
abstract::The present study dealt with the isolation, identification and characterization of pigments from red snow samples of the Quito coastal front glacier (S 62º 27,217', W 059º 45,960') in Greenwich, Archipelago South Shetland, Antarctica, during summer 2013. As a strain of Shewanella was found to be the most common and ab...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866522666150915122247
更新日期:2015-01-01 00:00:00
abstract::Aspergillus sp. phytase contains five disulfide bonds. In order to elucidate their role, the reactivation and refolding of phytase in the absence and presence of dithiothreitol (DTT) was investigated. The results indicated that the disulfide bonds play an important role in the catalytic activity and conformational sta...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866054395752
更新日期:2005-08-01 00:00:00
abstract::Alpha-gliadins isolated by carboxymethylcellulose chromatography contain noncovalently bound glucose probably due to contaminating proteoglycans and to material shed from the column. Traces of carbohydrate remain strongly bound to alpha-gliadins even after harsh denaturation, but our results indicate alpha-gliadins ar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408995
更新日期:2002-02-01 00:00:00
abstract::Prediction of thermophilic and mesophilic protein plays a crucial role in both biochemistry and bioengineering. In this study, a different mode of pseudo amino acid composition (PseAAC) was proposed to formulate the protein samples by integrating the amino acid composition, the physic chemical features, as well as the...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611795446085
更新日期:2011-07-01 00:00:00
abstract::The importance of the intestinal microbiota of animals is widely acknowledged because of its vital role in the health of animals. There are complex communities of microbiota, which colonize the gastrointestinal tract. Intestinal microbiota are conductive to animal health and the development of the host immune system. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866524666170223143615
更新日期:2017-01-01 00:00:00
abstract::Bromelain inhibitor, "bromein", is a proteinase-inhibitor specific to the cysteine proteinase bromelain from pineapple stem. In the stem, eight bromein isoforms are known to exist, and each isoform has a short peptide (light chain) and a long one (heavy chain) with five disulfide bonds. The three-dimensional structure...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/0929866525666180821115432
更新日期:2018-01-01 00:00:00
abstract::Galanin is a neuropeptide that is widely distributed in the central and peripheral nervous systems. Some small cell lung carcinoma (SCLC) cell lines such as SBC-3A release only the high-molecular-mass form, with lower molecular mass forms being undetectable. To investigate the mechanism of processing of progalanin to ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611796378693
更新日期:2011-10-01 00:00:00
abstract::BmK ITa1 cDNA was cloned and highly expressed in E. coli and insect cell. SDS-PAGE and western blot analysis revealed that subunit molecular weight of expression products is about 40 kDa and 10 kDa respectively. The expression product purified by a Ni(2+)-IDA-sepharose 6B column was toxic for insect, which indicated t...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866023408472
更新日期:2002-10-01 00:00:00
abstract::Antimicrobial peptides (AMPs) constitute an important alternative in the search for new treatments against pathogens. We analyzed the sequence variability in cytokine and chemokine proteins to investigate whether these molecules contain a sequence useful in the development of new AMPs. Cluster analysis allowed the ide...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866511320050001
更新日期:2013-05-01 00:00:00
abstract::Protein-splicing inteins are widespread in nature and have found many applications in protein research and engineering. The mechanism of protein splicing typically requires a nucleophilic amino acid residue at both position 1 (first residue of intein) and position +1 (first residue after intein), however it was not cl...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986611797642760
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Protealysin, a zinc metalloprotease of Serratia proteamaculans, is the prototype of a new group within the peptidase family M4. Protealysin-like proteases (PLPs) are widely spread in bacteria but are also found in fungi and archaea. The biological functions of PLPs have not been well studied, but published d...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866526666181212114907
更新日期:2019-01-01 00:00:00
abstract::DrTI was effective against trypsin-like enzymes from A. kuehniella and C. cephalonica, however an artificial diet was insufficient to affect the survival and body weight of either insect. The inhibitor stimulated chymotrypsin-like enzymes and probably induced the synthesis of enzymes insensitive to TLCK in neonate lar...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789839395
更新日期:2009-01-01 00:00:00
abstract::PD-L1 is a highly glycosylated type 1 ribosome inactivating protein, from Phytolacca dioica leaves, with the peculiarity to act also as a DNase. PD-L1 has been successfully crystallized using vapour diffusion and seeding techniques. Crystals belong to the monoclinic C2 space group, with unit cell dimensions a=161.01, ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780363899
更新日期:2007-01-01 00:00:00
abstract::In recent years, therapeutic proteins have become an important growing class of drugs in the pharmaceutics industry. The development of recombinant DNA technology has caused to appreciation of therapeutic value of many proteins and peptides in medicine. Currently, approximately 100 therapeutic proteins obtained approv...
journal_title:Protein and peptide letters
pub_type: 杂志文章,评审
doi:10.2174/092986652012131112125148
更新日期:2013-12-01 00:00:00
abstract::Proteases have been used not only for proteolysis but also in organic solvent-assisted religation processes. Here, we demonstrated the effect of salts on peptide bond resynthesis in Glutathione-S-transferase (GST) and have found it to be in the purview of the Hofmeister phenomena. Our results show that the efficiency ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986610789909395
更新日期:2010-01-01 00:00:00
abstract::Here, we show for the first time that non-fibrillar and spherical aggregates produced from PrP-(23-98) in the presence of NADPH plus copper ions are toxic to cultured cells and induce apoptotic signals. It is also confirmed that endogenous cellular PrP isoform is not required for toxicity to occur. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609787049475
更新日期:2009-01-01 00:00:00
abstract::It is important to understand the conformational biases that are present in unfolded states to understand protein folding. In this context, it is surprising that even a short tripeptide like AFA samples folded/ordered conformation as demonstrated recently by NMR experiments of the peptide in aqueous solution at 280 K....
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986607780989886
更新日期:2007-01-01 00:00:00
abstract::We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (H-GLLKXIKTLL-NH(2)). The most active compounds showed MIC-values of 12.5 and 25 microM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 microM and 11 microM against E. ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/092986609789055421
更新日期:2009-01-01 00:00:00
abstract::Identifying protein complexes in protein-protein interaction (PPI) networks is a fundamental problem in computational biology. High-throughput experimental techniques have generated large, experimentally detected PPI datasets. These interactions represent a rich source of data that can be used to detect protein comple...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866521666140320111720
更新日期:2014-07-01 00:00:00
abstract::Porins are integral membrane proteins found in the outer membrane of bacteria, mitochondria and chloroplasts. Herein, we have reviewed sequence and structural understanding about bacterial porins. The first porin structure from Rhodobacter capsulatus at 1.8 Å resolution in 1991 till the recent structural advancement, ...
journal_title:Protein and peptide letters
pub_type: 杂志文章
doi:10.2174/0929866521666140827110755
更新日期:2015-01-01 00:00:00