Abstract:
:Twenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of patients performed above chance when generating short spans of the sequence. This high-generation group showed SRT learning that was similar in magnitude to that of controls. Their learning was evident from the very 1st block; however, unlike controls, learning did not develop further with continued testing. A subset of 12 patients and 11 controls performed the SRT in conjunction with positron emission tomography. High-generation performance, which corresponded to SRT learning in patients, correlated to activity in the premotor cortex and parahippocampus. These areas have been associated with stimulus-driven visuospatial processing. Taken together, these results suggest that a subset of patients who showed moderate success on the SRT used an explicit stimulus-driven strategy to process the sequential stimuli. This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern.
journal_name
Neuropsychologyjournal_title
Neuropsychologyauthors
Marvel CL,Turner BM,O'Leary DS,Johnson HJ,Pierson RK,Ponto LL,Andreasen NCdoi
10.1037/0894-4105.21.6.761subject
Has Abstractpub_date
2007-11-01 00:00:00pages
761-77issue
6eissn
0894-4105issn
1931-1559pii
2007-15625-014journal_volume
21pub_type
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