The neural correlates of implicit sequence learning in schizophrenia.

Abstract:

:Twenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of patients performed above chance when generating short spans of the sequence. This high-generation group showed SRT learning that was similar in magnitude to that of controls. Their learning was evident from the very 1st block; however, unlike controls, learning did not develop further with continued testing. A subset of 12 patients and 11 controls performed the SRT in conjunction with positron emission tomography. High-generation performance, which corresponded to SRT learning in patients, correlated to activity in the premotor cortex and parahippocampus. These areas have been associated with stimulus-driven visuospatial processing. Taken together, these results suggest that a subset of patients who showed moderate success on the SRT used an explicit stimulus-driven strategy to process the sequential stimuli. This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern.

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Marvel CL,Turner BM,O'Leary DS,Johnson HJ,Pierson RK,Ponto LL,Andreasen NC

doi

10.1037/0894-4105.21.6.761

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

761-77

issue

6

eissn

0894-4105

issn

1931-1559

pii

2007-15625-014

journal_volume

21

pub_type

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