The relationships between apathy and executive dysfunction in multiple sclerosis.

Abstract:

BACKGROUND:Neuropsychiatric symptoms are common in multiple sclerosis (MS). Among these, apathy is relatively frequent but its relationships with cognitive dysfunctions have been poorly investigated. OBJECTIVE:To explore cognitive correlates of apathy with or without depression ("pure apathy") in MS patients. MATERIAL AND METHOD:Nondemented MS patients (n = 125), consecutively referred to the Multiple Sclerosis Center of Moscati Hospital, in Avellino, Italy, underwent the Apathy Evaluation Scale Self-Rated (AES-S), the Hamilton Depression Rating Scale (HDRS), and a comprehensive neuropsychological battery. RESULTS:According to cut-off scores of AES-S (≥36), of HDRS (≥15) and criteria for diagnosis of apathy and major depression, the sample was divided into 4 subgroups: 49 patients without apathy or depression (A-D-), 20 patients with "pure" apathy (A+D-), 29 patients with depression only (A-D+), and 27 patients with apathy and depression (A+D+). Cognitive performance significantly differed in the 4 groups: in particular MS patients with apathy (A+D- and A+D+) performed significantly worse on executive tasks than patients without apathy, whereas patients with "pure" apathy (A+D-) performed significantly worse than patients without apathy only on executive tasks tapping cognitive control abilities. CONCLUSIONS:We found a significant relationship between apathy and dysexecutive defects in MS, consistent with the hypothesis that dysfunctions of prefrontal cortico-subcortical circuits contribute to specific neuropsychiatric syndromes in MS patients. (PsycINFO Database Record

journal_name

Neuropsychology

journal_title

Neuropsychology

authors

Raimo S,Trojano L,Spitaleri D,Petretta V,Grossi D,Santangelo G

doi

10.1037/neu0000279

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

767-74

issue

6

eissn

0894-4105

issn

1931-1559

pii

2016-16655-001

journal_volume

30

pub_type

杂志文章
  • Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort.

    abstract:INTRODUCTION:Nonmotor symptoms, including depression, anxiety, apathy, and cognitive dysfunction, are common in Parkinson's disease (PD). Although a link between mood symptoms and cognitive impairment in PD has been theorized vis-à-vis striatal dopamine depletion, studies have been inconsistent regarding the relationsh...

    journal_title:Neuropsychology

    pub_type: 杂志文章,多中心研究

    doi:10.1037/neu0000583

    authors: Jones JD,Kurniadi NE,Kuhn TP,Szymkowicz SM,Bunch J,Rahmani E

    更新日期:2019-11-01 00:00:00

  • Developmental gender differences in children in a virtual spatial memory task.

    abstract:OBJECTIVE:Behavioral achievements are the product of brain maturation. During postnatal development, the medial temporal lobe completes its maturation, and children acquire new memory abilities. In recent years, virtual reality-based tasks have been introduced in the neuropsychology field to assess different cognitive ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000054

    authors: León I,Cimadevilla JM,Tascón L

    更新日期:2014-07-01 00:00:00

  • Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type.

    abstract::Twenty-seven research participants with dementia of the Alzheimer type were studied with the California Verbal Learning Test (D. C. Delis, J. H. Kramer, E. Kaplan, & B. A. Ober, 1987) and standardized volume measures of the mesial temporal cortical gray matter, neocortical gray matter, thalamus, and caudate nuclei, fr...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章

    doi:10.1037//0894-4105.13.2.188

    authors: Stout JC,Bondi MW,Jernigan TL,Archibald SL,Delis DC,Salmon DP

    更新日期:1999-04-01 00:00:00

  • Hemispheric interactions during a face--word Stroop-analog task.

    abstract::A Stroop-analog task with faces and words was developed to investigate intrahemispheric and interhemispheric Stroop effects (SEs). Lateralized faces and words were used in an attempt to invoke right- and left-hemispheric specialization, respectively. A prototypical male face, female face, and baby face and the corresp...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.14.4.579

    authors: Kavcic V,Clarke JM

    更新日期:2000-10-01 00:00:00

  • Cognition and daily life functioning among persons with serious mental illness: A cluster analytic examination of heterogeneity on the Test of Grocery Shopping Skills.

    abstract:OBJECTIVE:To characterize variability in daily life functioning among individuals with serious mental illness based on a naturalistic performance measure of grocery shopping and standard neuropsychological tasks using cluster analytic methods. METHODS:A naturalistic performance measure, the Test of Grocery Shopping Sk...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000700

    authors: Harris M,Blanco EA,Rempfer M

    更新日期:2021-01-01 00:00:00

  • Neural correlates of recognition and naming of musical instruments.

    abstract:OBJECTIVE:Retrieval of lexical (names) and conceptual (semantic) information is frequently impaired in individuals with neurological damage. One category of items that is often affected is musical instruments. However, distinct neuroanatomical correlates underlying lexical and conceptual knowledge for musical instrumen...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000273

    authors: Belfi AM,Bruss J,Karlan B,Abel TJ,Tranel D

    更新日期:2016-10-01 00:00:00

  • The beneficial influence of inattention on visual interference in schizophrenia.

    abstract:OBJECTIVE:Schizophrenia is associated with poor spatial attention. However, although this deficit undermines the perception of target information, it may be helpful for ignoring irrelevant inputs. The present study examined whether event-related brain potential (ERP) indices of visual spatial attention predicted the ma...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000280

    authors: Brodeur MB,Kiang M,Christensen BK

    更新日期:2016-09-01 00:00:00

  • Interpreting high scores on the NIH Toolbox Cognition Battery: Potential utility for detecting cognitive decline in high-functioning individuals.

    abstract:OBJECTIVE:It is well established that it is common for healthy adults to obtain one or more low scores when multiple neuropsychological tests are administered; however, very little is known about the normal frequency of high scores. The current study reports high-score base rates for the National Institutes of Health T...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000691

    authors: Karr JE,Iverson GL

    更新日期:2020-07-30 00:00:00

  • Trauma-related psychiatric and behavioral conditions are uniquely associated with sustained attention dysfunction.

    abstract:OBJECTIVE:It is increasingly recognized that trauma victims, particularly Veterans, have co-occurring psychological and physical conditions that impact cognition, especially the domains of sustained attention and executive functioning. Although previous work has generally attempted to isolate the unique cognitive effec...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000525

    authors: Esterman M,Fortenbaugh FC,Pierce ME,Fonda JR,DeGutis J,Milberg W,McGlinchey R

    更新日期:2019-07-01 00:00:00

  • Alerting and orienting in Alzheimer's disease.

    abstract::Recently, researchers (E. Festa-Martino, B. R. Ott, & W. C. Heindel, 2004; A. Tales, J. L. Muir, A. Bayer, R. Jones, & R. J. Snowden, 2002; A. Tales, J. L. Muir, A. Bayer, & R. J. Snowden, 2002 have found significantly abnormal spatial orienting together with the abolishment of the alerting effect in Alzheimer's disea...

    journal_title:Neuropsychology

    pub_type: 评论,杂志文章

    doi:10.1037/0894-4105.20.6.752

    authors: Tales A,Snowden RJ,Brown M,Wilcock G

    更新日期:2006-11-01 00:00:00

  • The mechanisms of far transfer from cognitive training: Review and hypothesis.

    abstract:OBJECTIVE:General intelligence is important for success in daily life, fueling interest in developing cognitive training as an intervention to improve fluid ability (Gf). A major obstacle to the design of effective cognitive interventions has been the paucity of hypotheses bearing on mechanisms underlying transfer of c...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000235

    authors: Greenwood PM,Parasuraman R

    更新日期:2016-09-01 00:00:00

  • Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity.

    abstract:OBJECTIVE:The last 25 years have seen profound changes in neurocognitive rehabilitation that continue to motivate its evolution. Although the concept of nervous system plasticity was discussed by William James (1890), the foundation for experience-based plasticity had not reached the critical empirical mass to seriousl...

    journal_title:Neuropsychology

    pub_type: 杂志文章,评审

    doi:10.1037/neu0000396

    authors: Crosson B,Hampstead BM,Krishnamurthy LC,Krishnamurthy V,McGregor KM,Nocera JR,Roberts S,Rodriguez AD,Tran SM

    更新日期:2017-11-01 00:00:00

  • Implicit and explicit memory in children with congenital and acquired brain disorder.

    abstract::Implicit and explicit memory were examined in 8- to 15-year-old children with myelomeningocele and shunted hydrocephalus, severe traumatic brain injuries, or orthopedic injuries. Each group included between 22 and 29 children. Children completed a fragmented picture identification task to assess perceptual priming and...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.19.5.618

    authors: Yeates KO,Enrile BG

    更新日期:2005-09-01 00:00:00

  • Abstract reasoning in autism: a dissociation between concept formation and concept identification.

    abstract::The concept identification and concept formation aspects of abstract reasoning were examined in 90 nonmentally retarded individuals with autism and 107 normal controls. It was hypothesized that pronounced deficits would be found on concept formation tests, whereas performance on concept identification tests would be r...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.16.3.327

    authors: Minshew NJ,Meyer J,Goldstein G

    更新日期:2002-07-01 00:00:00

  • Benefits of immediate repetition versus long study presentation on memory in amnesia.

    abstract:OBJECTIVE:This study aimed to resolve discrepant findings in the literature regarding the effects of massed repetition and a single long study presentation on memory in amnesia. METHOD:Experiment 1 assessed recognition memory in 9 amnesic patients and 18 controls following presentation of a study list that contained i...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0018625

    authors: Verfaellie M,LaRocque KF,Rajaram S

    更新日期:2010-07-01 00:00:00

  • Visual confrontation naming following left anterior temporal lobectomy: a comparison of surgical approaches.

    abstract::Change in visual confrontation naming was examined following left (speech dominant) anterior temporal lobectomy (ATL) as a function of surgical technique and patient characteristics. Two hundred seventeen patients with intractable left temporal lobe epilepsy were selected according to standard criteria across 8 center...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.13.1.3

    authors: Hermann BP,Perrine K,Chelune GJ,Barr W,Loring DW,Strauss E,Trenerry MR,Westerveld M

    更新日期:1999-01-01 00:00:00

  • Individual differences in reasoning and visuospatial attention are associated with prefrontal and parietal white matter tracts in healthy older adults.

    abstract:OBJECTIVE:Although reasoning and attention are 2 cognitive processes necessary for ensuring the efficiency of many everyday activities in older adults, the role of white matter integrity in these processes has been little studied. This is an important question due to the role of white matter integrity as a neural subst...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000264

    authors: Monge ZA,Greenwood PM,Parasuraman R,Strenziok M

    更新日期:2016-07-01 00:00:00

  • Time perception and reproduction in young adults with attention deficit hyperactivity disorder.

    abstract::Adults with attention deficit hyperactivity disorder (ADHD; n = 104) were compared with a control group (n = 64) on time estimation and reproduction tasks. Results were unaffected by ADHD subtype or gender. The ADHD group provided larger time estimations than the control group, particularly at long intervals. This bec...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.15.3.351

    authors: Barkley RA,Murphy KR,Bush T

    更新日期:2001-07-01 00:00:00

  • Relations between volumetric measures of brain structure and attentional function in spina bifida: utilization of robust statistical approaches.

    abstract:OBJECTIVE:Weak structure-function relations for brain and behavior may stem from problems in estimating these relations in small clinical samples with frequently occurring outliers. In the current project, we focused on the utility of using alternative statistics to estimate these relations. METHOD:Fifty-four children...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000166

    authors: Kulesz PA,Tian S,Juranek J,Fletcher JM,Francis DJ

    更新日期:2015-03-01 00:00:00

  • Memory consolidation in aging and MCI after 1 week.

    abstract:OBJECTIVE:To assess consolidation in amnestic mild cognitive impairment (aMCI), controlling for differences in initial learning and using a protracted delay period for recall. METHOD:15 individuals with aMCI were compared with 15 healthy older adult controls on a story learning task. Subjects were trained to criteria ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000013

    authors: Walsh CM,Wilkins S,Bettcher BM,Butler CR,Miller BL,Kramer JH

    更新日期:2014-03-01 00:00:00

  • Sex differences favoring women in verbal but not in visuospatial episodic memory.

    abstract::Sex differences favoring women have been found in a number of studies of episodic memory. This study examined sex differences in verbal, nonverbal, and visuospatial episodic memory tasks. Results showed that although women performed at a higher level on a composite verbal and nonverbal episodic memory score, men perfo...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.15.2.165

    authors: Lewin C,Wolgers G,Herlitz A

    更新日期:2001-04-01 00:00:00

  • Neurocognitive intra-individual variability within HIV+ adults with and without current substance use.

    abstract:OBJECTIVE:HIV infection and current substance use (SU) are linked to cognitive and functional deficits, yet findings on their combined effects are mixed. Neurocognitive intraindividual variability, measured as dispersion of scores across a neuropsychological battery, is associated with worse cognitive outcomes and func...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000612

    authors: Arce Rentería M,Byrd D,Coulehan K,Miranda C,Fuentes A,Rosario AK,Morris EP,Rivera Mindt M

    更新日期:2020-03-01 00:00:00

  • Patients with Parkinson's disease display a dopamine therapy related negative bias and an enlarged range in emotional responses to facial emotional stimuli.

    abstract:OBJECTIVE:The literature on emotional processing in Parkinson's disease (PD) patients shows mixed results. This may be because of various methodological and/or patient-related differences, such as failing to adjust for cognitive functioning, depression, and/or mood. METHOD:In the current study, we tested PD patients a...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000371

    authors: Lundqvist D,Svärd J,Michelgård Palmquist Å,Fischer H,Svenningsson P

    更新日期:2017-09-01 00:00:00

  • Differential impairments in irony comprehension in brain-damaged individuals: Insight from contextual processing, theory of mind, and executive functions.

    abstract:OBJECTIVE:The comprehension of irony can be affected after brain injuries. The cognitive mechanisms accounting for such disorders remain yet unclear. The heterogeneity of cognitive profiles of brain-damaged individuals and the use of independent tests to measure the links between these mechanisms and the comprehension ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/neu0000682

    authors: Cordonier N,Fossard M,Champagne-Lavau M

    更新日期:2020-07-27 00:00:00

  • Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of Cicerone et al.'s (2000, 2005) systematic reviews.

    abstract::The present study provides a meta-analysis of cognitive rehabilitation literature (K = 115, N = 2,014) that was originally reviewed by K. D. Cicerone et al. (2000, 2005) for the purpose of providing evidence-based practice guidelines for persons with acquired brain injury. The analysis yielded a small treatment effect...

    journal_title:Neuropsychology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1037/a0013659

    authors: Rohling ML,Faust ME,Beverly B,Demakis G

    更新日期:2009-01-01 00:00:00

  • Neuropsychological impairment among manic, depressed, and mixed-episode inpatients with bipolar disorder.

    abstract::Previous research has demonstrated broad neurobehavioral abnormalities in bipolar affective disorder (cf. G. Cassens, L. Wolfe, & M. Zola, 1990). However, there have been no comparisons of neuropsychological function across patients with manic, depressed, or mixed subtypes. In the present study, 37 manic, 24 mixed-epi...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.16.1.84

    authors: Basso MR,Lowery N,Neel J,Purdie R,Bornstein RA

    更新日期:2002-01-01 00:00:00

  • Growth mixture modeling of academic achievement in children of varying birth weight risk.

    abstract::The extremes of birth weight and preterm birth are known to result in a host of adverse outcomes, yet studies to date largely have used cross-sectional designs and variable-centered methods to understand long-term sequelae. Growth mixture modeling (GMM) that utilizes an integrated person- and variable-centered approac...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/a0015676

    authors: Espy KA,Fang H,Charak D,Minich N,Taylor HG

    更新日期:2009-07-01 00:00:00

  • Sustained attention in children with two etiologies of early hydrocephalus.

    abstract::Several studies have shown that children with spina bifida meningomyelocele (SBM) and hydrocephalus have attention problems on parent ratings and difficulties in stimulus orienting associated with a posterior brain attention system. Less is known about response control and inhibition associated with an anterior brain ...

    journal_title:Neuropsychology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1037/a0013373

    authors: Swartwout MD,Cirino PT,Hampson AW,Fletcher JM,Brandt ME,Dennis M

    更新日期:2008-11-01 00:00:00

  • Perceptual priming of proper names in young and older normal adults and a patient with prosopanomia.

    abstract::The purpose of this study was to determine if normal participants and a patient with prosopanomia can be perceptually primed for proper names. To this end, 2 experiments were conducted. In Experiment 1, normative data were collected on 4 proper-name priming tasks. The variables of levels of processing at encoding and ...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037//0894-4105.11.2.232

    authors: Geva A,Moscovitch M,Leach L

    更新日期:1997-04-01 00:00:00

  • Orthography and the hemispheres: visual and linguistic aspects of letter processing.

    abstract::Hebrew and Arabic are Semitic languages with a similar morphological structure and orthographies that differ in visual complexity. Two experiments explored the interaction of the characteristics of orthography and hemispheric abilities on lateralized versions of a letter-matching task (Experiment 1) and a global-local...

    journal_title:Neuropsychology

    pub_type: 杂志文章

    doi:10.1037/0894-4105.18.1.174

    authors: Eviatar Z,Ibrahim R,Ganayim D

    更新日期:2004-01-01 00:00:00