当前位置： SCI文献检索 > ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS期刊下所有文献 > Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.

Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members.

Abstract：

:Constitutive androstane receptor (CAR) transactivation is enhanced by p160 coactivators, which include three members, SRC-1, SRC-2, and SRC-3. Each of the p160 coactivators enhanced mouse CAR (mCAR) transactivation of the CYP2B1 phenobarbital (PB)-responsive enhancer in transfected cultured cells and mouse hepatocytes in vivo. The cellular localization of the p160 coactivators in hepatocytes in vivo was not altered by PB treatment, nor did any of the p160 coactivators selectively colocalize with mCAR in the nucleus. Exogenous expression of each p160 coactivator mediated the PB-independent nuclear accumulation of mCAR in hepatocytes in vivo. Induction of Cyp2b10 gene expression by PB was equivalent or greater in mice null for each of the p160 coactivators than in wild type mice. These results indicate that the p160 coactivators are redundant with regard to enhancing CAR-mediated induction of cytochrome P450 genes. SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Xia J,Liao L,Sarkar J,Matsumoto K,Reddy JK,Xu J,Kemper B

doi

10.1016/j.abb.2007.09.005

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

49-57

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(07)00449-3

journal_volume

468

pub_type

杂志文章

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