Binding studies on aluminum(III)-albumin interaction.

Abstract:

:The present paper reports a quantitative investigation on the binding of aluminum to human serum albumin. Equilibrium dialysis and a general thermodynamic approach have been used to determine the binding parameters. Two aluminum binding sites have been identified on the albumin molecule, involving sites with single and double occupancy modes. The binding properties of these two distinct sites appear to undergo reciprocal influences, suggesting a possible interaction between the corresponding protein moieties. Both coordination modes proceed from weak interactions, as shown by the binding energies calculated.

journal_name

Arch Biochem Biophys

authors

Zatta P,Dalla Via L,Di Noto V

doi

10.1016/s0003-9861(03)00320-5

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

59-64

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003986103003205

journal_volume

417

pub_type

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