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Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines.

Abstract：

:We investigated whether expression of non-selective cation channels of the transient receptor potential canonical (TRPC) channel family are associated with proinflammatory cytokines in monocytes. Using quantitative RT-PCR we studied the expression of TRPC3, interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) in monocytes from 15 patients with essential hypertension and 16 age- and sex-matched normotensive control subjects. We observed an approximately 8-fold increase of TRPC3 transcripts in monocytes from patients with essential hypertension compared to normotensive control subjects (p<0.05). We found an approximately 3-fold increase of IL-1beta, and an approximately 9-fold increase of TNF-alpha in patients with essential hypertension compared to normotensive control subjects (each p<0.05). We observed a significant correlation between TRPC3 transcripts with systolic blood pressure, expression of IL-1beta, and TNF-alpha. Using quantitative RT-PCR we observed an association of TRPC3 transcripts and proinflammatory cytokines in monocytes.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Thilo F,Scholze A,Liu DY,Zidek W,Tepel M

doi

10.1016/j.abb.2007.12.006

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

57-62

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(07)00585-1

journal_volume

471

pub_type

杂志文章

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