Abstract:
:The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Wang Y,Zhu J,DeLuca HFdoi
10.1016/j.abb.2012.04.001subject
Has Abstractpub_date
2012-07-01 00:00:00pages
123-33issue
1eissn
0003-9861issn
1096-0384pii
S0003-9861(12)00132-4journal_volume
523pub_type
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