Where is the vitamin D receptor?

Abstract:

:The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body.

journal_name

Arch Biochem Biophys

authors

Wang Y,Zhu J,DeLuca HF

doi

10.1016/j.abb.2012.04.001

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

123-33

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(12)00132-4

journal_volume

523

pub_type

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