Abstract:
:The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of particular interest, is the revelation that allosteric networks transmit effects of binding at one site to influence troponin complex dynamics and structural-mediated signaling in often distal, functional sites in the myofilament. Our recent observations provide compelling evidence that allostery can explain the function of large-scale macromolecular events. Here we elaborate on our recent findings of interdomain communication within troponin C, using cutting-edge structural biology approaches, and highlight the importance of unveiling the unknown, distant communication networks within this system to obtain more comprehensive knowledge of how allostery impacts cardiac physiology and disease.
journal_name
Arch Biochem Biophysjournal_title
Archives of biochemistry and biophysicsauthors
Marques MA,Parvatiyar MS,Yang W,de Oliveira GAP,Pinto JRdoi
10.1016/j.abb.2018.12.026subject
Has Abstractpub_date
2019-03-15 00:00:00pages
95-100eissn
0003-9861issn
1096-0384pii
S0003-9861(18)30676-3journal_volume
663pub_type
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