Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide.

abstract：:The fibroblast growth factor receptors (FGFRs) and Ras/mitogen activated protein (RAS/MAP) signalling cascades are the main molecular pathways involved in breast carcinogenesis. This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphism...

journal_title：General physiology and biophysics

authors： Dankova Z,Zubor P,Grendar M,Kapinova A,Zelinova K,Jagelkova M,Gondova A,Dokus K,Kalman M,Lasabova Z,Danko J

更新日期：2017-12-01 00:00:00

abstract：:125I-labelled o-iodobenzoate (OIB) was prepared by means of an isotopic exchange reaction; its distribution and excretion were determined and its pharmacokinetic parameters in rats were calculated. The calculated value of the half-life of OIB elimination was 38.7 +/- 0.7 min, the distribution volume was 278.2 +/- 53.5...

journal_title：General physiology and biophysics

authors： Láznícek M,Kvĕtina J,Srámek B,Kronrád L,Hradílek P

更新日期：1983-08-01 00:00:00

abstract：:In the present work have been made some modifications of Münch's model, which concerns the explanation of biophysical bases of the problem of transport of water and assimilates. Then, by using the thermodynamic formalism of Kedem and Katchalsky (1958), we have made a mathematical description of the model. On this basi...

journal_title：General physiology and biophysics

authors： Kargol M

更新日期：1994-02-01 00:00:00

abstract：:The distributions of K, Na, Mg and Ca within frog ovarian and oviductal oocytes were studied by electron probe wavelength dispersive X-ray microanalysis. An important heterogeneity could be found both in nuclear and jelly coated oocytes. The highest K, Mg and, to a lesser extent, Na concentrations were found in the pi...

journal_title：General physiology and biophysics

authors： Burovina IV,Pivovarova NB,Pogorelov AG

更新日期：1985-06-01 00:00:00

abstract：:The character of structural changes in thylakoid membranes caused by temperature variation was investigated. Experiments were performed on maize leaf segments in vivo and in a closed temperature cycle 24-50-24 degrees C. Two biophysical methods were used for detection: luminescence and EPR. Arrhenius plots of delayed ...

journal_title：General physiology and biophysics

authors： Marković D,Jeremić M,Radenović C,Schara M

更新日期：1993-02-01 00:00:00

abstract：:Diabetes mellitus leads to bone disorders such as osteopenia and osteoporosis that can increase fracture risk. On the other hand, sodium tungstate is an inorganic compound which exerts anti-diabetic activity in experimental studies due to its suggested insulin-mimetic or antioxidant activity. Therefore this study was ...

journal_title：General physiology and biophysics

authors： Donmez BO,Ozturk N,Sarikanat M,Oguz N,Sari R,Ozdemir S

更新日期：2014-01-01 00:00:00

abstract：:Hyperglycemia impairs oxidative capacity in skeletal muscle. Muscle oxidative capacity is regulated by peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α). Transcutaneous carbon dioxide (CO2) enhances PGC-1α expression in skeletal muscle. Therefore, the aim of this study was to clarify the effects of...

journal_title：General physiology and biophysics

authors： Matsumoto T,Tanaka M,Nakanish R,Takuwa M,Hirabayashi T,Ono K,Ikeji T,Maeshige N,Sakai Y,Akisue T,Kondo H,Ishihara A,Fujino H

更新日期：2019-05-01 00:00:00

abstract：:The upregulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) was reported to be involved in regulating the levels of inflammatory markers and apoptosis in macrophages. This study aims to investigate the function and regulation of PCSK9 in myocardial ischaemia. The results of our study showed dramatically ...

journal_title：General physiology and biophysics

authors： Yang CL,Zeng YD,Hu ZX,Liang H

更新日期：2020-03-01 00:00:00

abstract：:The effects of both chronic hypoxia and acute intermittent hypoxia (AIH) on cardiovascular system are unclear. We designed this study to develop a rabbit model of hypertension by exposure to chronic hypobaric hypoxia (CHH) and to investigate the effects of AIH on hypertensive rabbits. Present study was performed in 13...

journal_title：General physiology and biophysics

authors： Yaman MO,Guner I,Uzun H,Sahin G,Yelmen N

更新日期：2014-01-01 00:00:00

abstract：:Sodium nitroprusside (SNP) is a nitric oxide (•NO) donor in vitro and in vivo. In this paper the time variation of the intracellular water proton nuclear magnetic resonance (NMR) effective relaxation time T'(2a) in SNP-treated human erythrocyte suspensions, containing 10 mM membrane impermeable paramagnetic MnCl2, has...

journal_title：General physiology and biophysics

authors： Lahajnar G,Sobotič B,Sepe A,Jazbinšek V,Pečar S

更新日期：2010-12-01 00:00:00

abstract：:The fluorescent probe chlortetracycline (CTC) was used to investigate redistribution of intracellular Ca2+ in concanavalin A (Con A)-stimulated human peripheral blood lymphocytes. The addition of the mitogen to CTC-equilibrated lymphocytes induced (within 10 to 15 minutes) a Con A-concentration dependent decrease in C...

journal_title：General physiology and biophysics

authors： Gukovskaya AS,Zinchenko VP,Ryabichenko VV,Astashkin EI

更新日期：1983-10-01 00:00:00

abstract：:We studied physical properties of the monolayers and bilayer lipid membranes (BLM) formed by calix[6]arene carboxylic acid derivative (CX) and its mixtures with diphytanoylphosphatidylcholine (DPhPC) by means of measurement surface pressure, surface dipole potential and electrostriction. CX forms stable monolayers at ...

journal_title：General physiology and biophysics

authors： Vitovič P,Subjaková V,Hianik T

更新日期：2013-06-01 00:00:00

abstract：:Stationary and time-dependent fluorescence were measured for a donor/ acceptor (DA) pair bound to membrane proteins of bovine erythrocyte ghosts. The donor N-(p-(2-benzoxazolyl)phenyl)-maleimide (BMI) and the acceptor fluram bind to SH- and NH2-residues, respectively. The fluorescence spectra and the time-dependent em...

journal_title：General physiology and biophysics

authors： Fuchs HM,Hof M,Mudogo V,Lawaczeck R

更新日期：1997-03-01 00:00:00

abstract：:Liposomes and proteoliposomes obtained from rat brain were used; structural changes induced by Vc5 cytotoxin (CT) from Central Asia cobra venom have been studied by the EPR method using spin probes (5-, 10-, or 12-doxylstearic acid). The addition of CT to liposome samples, containing spin probes resulted in the appear...

journal_title：General physiology and biophysics

authors： Aripov TF,Salakhutdinov BA,Salikhova ZT,Sadykov AS,Tashmukhamedov BA

更新日期：1984-12-01 00:00:00

abstract：:The membrane lipid and fatty acid compositions of red blood cells from a paramyotonia patient were investigated. Cholesterol and total phospholipid contents in paramyotonia were not different from control. Only the sphingomyelin content was lower, and thus the molar ratio of phosphatidylcholine/sphingomyelin was highe...

journal_title：General physiology and biophysics

authors： Szymanska G,Marx A,Melzner I,Sarzala MG,Rüdel R

更新日期：1986-04-01 00:00:00

abstract：:Fusion of neuraminidase or trypsin pretreated human erythrocytes and untreated cells was performed. The obtained doublets had a permanent dipole moment which disappeared as a function of time. Since the dipole moment disappearance is due to protein interdiffusion the lateral diffusion constant may be determined. This ...

journal_title：General physiology and biophysics

authors： Donath E,Arndt R

更新日期：1984-06-01 00:00:00

abstract：:Tissue intermittent hypoxia (IH) occurs in obstructive sleep apnea, sickle cell anemia, physical exercise and other conditions. Poor gas solubility and slow diffusion through culture media hampers mimicking IH-induced transitions of O(2) in vitro. We aimed to develop a system enabling exposure of cultured cells to IH ...

journal_title：General physiology and biophysics

authors： Polak J,Studer-Rabeler K,McHugh H,Hussain MA,Shimoda LA

更新日期：2015-07-01 00:00:00

abstract：:Cochlear spiral ganglion neurons provide the only pathway for transmitting sound evoked activity from the hair cells to the central auditory system. Serotonin plays a role in the response properties of central auditory neurons. However, knowledge about the role of serotonin in the peripheral auditory nervous system re...

journal_title：General physiology and biophysics

authors： Yu C,Liu J,Chen Y,Tang Y

更新日期：2013-03-01 00:00:00

abstract：:Fasting for 48 h and the same period of recovery induced by 48 h refeeding increased rat hypothalamic monoamine oxidase (MAO) activity. However, in the interscapular brown adipose tissue (IBAT), only refeeding induced a significant elevation of the enzyme activity. As far as hypothalamic antioxidative enzymes are conc...

journal_title：General physiology and biophysics

authors： Cvijic G,Djordjevic J,Davidovic V

更新日期：2000-09-01 00:00:00

abstract：:Expression of the haptoglobin (Hp) gene is liver specific and acute phase (AP) responsive. It was previously shown that transcriptional induction process of the rat Hp gene during turpentine induced AP response has been mediated by the liver nucleoprotein p29 which was shown to be homologous to the HMG-1 chromatin-ass...

journal_title：General physiology and biophysics

authors： Grigorov I,Milosavljević T,Cvetković I,Petrović M

更新日期：2001-12-01 00:00:00

abstract：:Electron spin resonance spectroscopy (ESR) was used to study the effects of amphiphilic amines of the carbamate, amide, and ester type and amine oxide on the photosynthetic system of spinach chloroplasts. The ESR signal II connected to the photosynthetic center PS II donor side was observed to diminish in the presence...

journal_title：General physiology and biophysics

authors： Sersen F,Balgavý P,Devínsky F

更新日期：1990-12-01 00:00:00

abstract：:The present results suggest that laminin-1 and 3 are localized in the specialized Schwann cells of Pacinian corpuscles, in spite of incomplete deposition of the basal lamina on the surface of their cytoplasmic processes. In addition, laminin-3 is concentrated and probably function as a stop protein not only in the neu...

journal_title：General physiology and biophysics

authors： Dubový P,Svízenská I,Jancálek R,Klusáková I

更新日期：1999-12-01 00:00:00

abstract：:The polyamines spermine and spermidine and the diamine putrescine inhibit lipid peroxidation in phospholipid liposome suspensions and rat liver homogenates. Using the chemiluminescence technique the antioxidant activity of polyamines was found to be due to reactions with the free radical intermediates of lipid peroxid...

journal_title：General physiology and biophysics

authors： Pavlovic DD,Uzunova P,Galabova T,Peneva V,Sokolova Z,Bjelakovic G,Ribarov S

更新日期：1992-04-01 00:00:00

abstract：:Although the A1 adenosine receptor (A1 receptor), the main adenosine receptor type in cardiac muscle, is involved in powerful cardioprotective processes such as ischemic preconditioning, the atrial A1 receptor reserve has not yet been quantified for the direct negative inotropic effect of adenosine. In the present stu...

journal_title：General physiology and biophysics

authors： Kiss Z,Pak K,Zsuga J,Juhasz B,Varga B,Szentmiklosi AJ,Haines DD,Tosaki A,Gesztelyi R

更新日期：2013-09-01 00:00:00

abstract：:Quercetin and epigallocatechin gallate are two of the most abundant polyphenols in dietary plants, including apples, onions, red wine and green tea. The bioactivity of polyphenols is linked to their ability to interact with cell membranes without being internalized. The aim of the present study was to assess the short...

journal_title：General physiology and biophysics

authors： Margina D,Ilie M,Manda G,Neagoe I,Mocanu M,Ionescu D,Gradinaru D,Ganea C

更新日期：2012-03-01 00:00:00

abstract：:For characterization of Na(+),K(+)-ATPase, a key enzyme involved in maintenance of intracellular sodium homeostasis, expression of alpha1 subunit and the ATP- and Na(+)-binding properties were investigated by Western blot analysis and by enzyme kinetics, respectively. Previous studies documented time-dependent alterat...

journal_title：General physiology and biophysics

authors： Javorková V,Mézešová L,Vlkovičová J,Vrbjar N

更新日期：2010-09-01 00:00:00

abstract：UNLABELLED:The effect of melatonin (MLT) on the isolated rat heart was studied using the standard perfusion conditions (Langendorff preparation) and model of calcium paradox (Ca(2+)-paradox). Ca(2+)-paradox was induced by 1 minute perfusion with Ca(2+)-free Krebs-Henseleit (KH) solution and subsequent 20 minutes perfus...

journal_title：General physiology and biophysics

authors： Vazan R,Styk J,Béder I,Pancza D

更新日期：2003-03-01 00:00:00

abstract：:The possibility of obtaining information about the radius of high and low conductance states of channels in multichannel membranes was tested experimentally. In spite of the interference of non-electrolytes on the numbers of channels that appeared in the membrane, the non-electrolyte-exclusion method was successfully ...

journal_title：General physiology and biophysics

authors： Krasilnikov OV,Merzlyak PG,Yuldasheva LN,Nogueira RA

更新日期：1998-12-01 00:00:00

abstract：:Aquaporin attracted attention not only of physiologists and biophysicists, but also of chemical engineers. Here we critically analyze a paper describing aquaporin-based artificial membranes, suggested for forward osmosis-based water purification (Wang et al. 2012, Small 8, pp. 1185-1190). Related papers published late...

journal_title：General physiology and biophysics

authors： Kocherginsky N

更新日期：2013-12-01 00:00:00

abstract：:The effects of alamethicin on the membrane barrier function of rabbit erythrocytes, human platelets and sarcoplasmic reticulum vesicles, as well as on that of brain microsomes and liver mitochondria of the rat were compared. An upset of the barrier function was observed for plasma membranes of brain microsomes as well...

journal_title：General physiology and biophysics

authors： Ritov VB,Tverdislova IL,Avakyan TYu,Menshikova EV,Leikin YuN,Bratkovskaya LB,Shimon RG

更新日期：1992-02-01 00:00:00