The role of genomics and proteomics: technologies in studying non-alcoholic fatty liver disease.

abstract：:Hepatic stellate cells (HSC) play an important role in liver fibrogenesis. They are also key players in liver regeneration as part of the stem cell niche of hepatocytes and hepatic progenitor cells. They produce growth stimulating and inhibiting factors for these epithelial cell compartments. In addition, recent studi...

journal_title：Clinics in liver disease

authors： Roskams T

更新日期：2008-11-01 00:00:00

abstract：:Understanding of the pathogenesis of hepatic fibrosis on a molecular level has led to the identification of several putative serum markers of hepatic fibrosis. Either individually or in combination, these serum markers appear capable of determining early and advanced hepatic fibrosis. Radiological determination of hep...

journal_title：Clinics in liver disease

authors： Kelleher TB,Afdhal N

更新日期：2005-11-01 00:00:00

abstract：:Ascites is the most common complication of cirrhosis. It is associated with profound changes in the splanchnic and systemic circulation and with renal abnormalities. The development of ascites is related to the existence of severe sinusoidal portal hypertension that causes marked splanchnic arterial vasodilation and a...

journal_title：Clinics in liver disease

authors： Cárdenas A,Bataller R,Arroyo V

更新日期：2000-05-01 00:00:00

abstract：:The dual blood supply of the liver, originating from the portal vein and the hepatic artery, makes it relatively resistant to minor circulatory disturbances. However, hepatic manifestations of common cardiovascular disorders are frequently encountered in both the inpatient and outpatient setting. Beginning with the ma...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2011-02-01 00:00:00

abstract：:Standard therapy with pegylated interferon and ribavirin for chronic hepatitis C is effective in 40% to 50% of individuals with genotype 1 hepatitis C virus (HCV) infection and is associated with significant treatment-related toxicities. Newly developed small molecules that target key enzymes essential for HCV replica...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2009-08-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterized by the presence of high-titer disease specific autoantibodies directed against mitochondrial antigens (AMA) of the inner mitochondrial membrane, that are members of the 2-oxo acid complex. Among numerous other autoantibodies found in PBC the focus of ongoing studies is ...

journal_title：Clinics in liver disease

authors： Bogdanos DP,Baum H,Vergani D

更新日期：2003-11-01 00:00:00

abstract：:In conclusion, the natural history of chronic HCV infection has not yet been fully defined. Current data suggest that the process runs an indolent course during the first two decades after initial infection, accounting for modest morbidity and mortality. Serious sequelae are more likely to emerge as the disease proces...

journal_title：Clinics in liver disease

authors： Seeff LB

更新日期：1997-11-01 00:00:00

abstract：:Osteopenia, in the form of osteoporosis, is a common complication of chronic cholestatic liver diseases and, although its cause is poorly understood, it appears to be intimately related to the cholestasis itself. With more patients surviving longer with successful liver transplantation, the clinical significance of su...

journal_title：Clinics in liver disease

authors： Hay JE

更新日期：1998-05-01 00:00:00

abstract：:Increased survival for young liver transplant recipients has greatly improved. Increasing success has led to broader indications, thereby increasing the number of potential recipients. Pediatric liver centers are developing new strategies to cope with the ever-increasing demands for suitable size appropriate grafts. U...

journal_title：Clinics in liver disease

authors： Abramson O,Rosenthal P

更新日期：2000-08-01 00:00:00

abstract：:Immunoglobulin G4 (IgG4)-related sclerosing cholangitis (IgG4-SC) is the biliary manifestation of the multisystem IgG4-related disease. IgG4-SC presents with biliary strictures and/or masses that can bear a striking similarity to other malignant and inflammatory diseases. Diagnosis is based on a combination of clinica...

journal_title：Clinics in liver disease

authors： Smit WL,Culver EL,Chapman RW

更新日期：2016-02-01 00:00:00

abstract：:HCV infection becomes persistent in many patients who are otherwise immune competent. There is increasing support for potential contribution of innate immune response and viral interference with its components to the subsequent outcome. As for the adaptive immune response, humoral immunity may be largely ineffective d...

journal_title：Clinics in liver disease

authors： Chang KM

更新日期：2003-02-01 00:00:00

abstract：:Renal dysfunction is a frequent complication in patients with endstage liver disease awaiting orthotopic liver transplantation. Although the stereotypical form of renal dysfunction is the hepatorenal syndrome, common causes of acute kidney injury include prerenal azotemia and acute tubular necrosis in this population....

journal_title：Clinics in liver disease

authors： Lau C,Martin P,Bunnapradist S

更新日期：2011-11-01 00:00:00

abstract：:Decision analysis helps evaluate competing strategies under conditions of uncertainty in a wide variety of clinical settings. Despite some limitations, decision trees and Markov models remain essential tools for medical decision analysts. These techniques allow comparison of competing management strategies in a quanti...

journal_title：Clinics in liver disease

authors： Kim WR

更新日期：2005-05-01 00:00:00

abstract：:The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advanci...

journal_title：Clinics in liver disease

authors： Feng S,Lai JC

更新日期：2014-08-01 00:00:00

abstract：:The study of hepatitis C virus (HCV) molecular virology is helping to shape the future of our anti-HCV strategies by identifying new antiviral targets. With the advent of agents that specifically target individual HCV proteins, HCV-specific therapy has arrived. Key to these efforts is the development of high-efficienc...

journal_title：Clinics in liver disease

authors： Glenn JS

更新日期：2005-08-01 00:00:00

abstract：:Although several mouse models of AIH have been described, no model is ideal. Indeed, the disease is self-limited in each model, and none is associated with significant liver fibrosis or progression to cirrhosis. Nevertheless, these models should be useful for testing different hypotheses regarding the initiation of AI...

journal_title：Clinics in liver disease

authors： Howell CD

更新日期：2002-08-01 00:00:00

abstract：:Primary sclerosing cholangitis is characterized by progressive fibrosing obliteration of the biliary tract. In some cases the disease is restricted to the small bile ducts, but most patients develop fibrotic stenoses of the larger bile ducts. Despite advances in magnetic resonance cholangiography, in unclear cases end...

journal_title：Clinics in liver disease

authors： Gotthardt D,Stiehl A

更新日期：2010-05-01 00:00:00

abstract：:Noncirrhotic portal hypertension represents a heterogeneous group of conditions that have distinct clinical and hemodynamic features that often help distinguish them from cirrhosis. [figure: see text] The sites of portal flow resistance may not be precisely localized to one area of the hepatic lobule and may extend be...

journal_title：Clinics in liver disease

authors： Molina E,Reddy KR

更新日期：2001-08-01 00:00:00

abstract：:In the past two decades, pediatric liver transplantation has become the state-of-the-art operation with anticipated success and limited mortality. The future success of pediatric liver transplantation will require thoughtful solutions to the delicate balance of risk to donors and recipients, the complex needs of the a...

journal_title：Clinics in liver disease

authors： Tiao G,Ryckman FC

更新日期：2006-02-01 00:00:00

abstract：:Early diagnosis of HCC is possible because certain risk factors for this tumor are known and because sensitive and relatively inexpensive diagnostic tools are available. Early diagnosis of HCC is also possible because of the long phase of asymptomatic tumor growth and the tumor's tendency to grow as a solitary mass in...

journal_title：Clinics in liver disease

authors： Colombo M

更新日期：2001-02-01 00:00:00

abstract：:Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other c...

journal_title：Clinics in liver disease

authors： Gonzalez HC,Jafri SM,Gordon SC

更新日期：2017-02-01 00:00:00

abstract：:In this article, the 4 phases of chronic HBV infection are reviewed and the factors that are associated with disease progression and the development of hepatocellular carcinoma (HCC) and cirrhosis are discussed. Also discussed is what is known to date about how to identify persons at the highest risk of developing HCC...

journal_title：Clinics in liver disease

authors： McMahon BJ

更新日期：2010-08-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovari...

journal_title：Clinics in liver disease

authors： Lim HW,Bernstein DE

更新日期：2018-02-01 00:00:00

abstract：:Hepatic changes resulting from the regular ingestion of alcohol are many and include fat infiltration, alcoholic hepatitis, and cirrhosis. Only 10% to 15% of chronic alcoholics develop liver disease. Women are more susceptible. An area of considerable importance is the high prevalence of concomitant infection with hep...

journal_title：Clinics in liver disease

authors： Maddrey WC

更新日期：2000-02-01 00:00:00

abstract：:Scientists and clinicians have made tremendous advances in understanding the pathogenesis of hepatitis C virus (HCV) infection and have developed impressive strategies for treating this hepatotropic virus in the short time since its discovery in 1989. This article goes beyond the current guidelines for the treatment o...

journal_title：Clinics in liver disease

authors： Darling JM,Fried MW

更新日期：2006-11-01 00:00:00

abstract：:Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discuss...

journal_title：Clinics in liver disease

authors： Habib A,Desai K,Hickey R,Thornburg B,Lewandowski R,Salem R

更新日期：2015-05-01 00:00:00

abstract：:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

journal_title：Clinics in liver disease

authors： Bunchorntavakul C,Reddy KR

更新日期：2013-11-01 00:00:00

abstract：:Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. ...

journal_title：Clinics in liver disease

authors： Theocharidou E,Suddle AR

更新日期：2019-05-01 00:00:00

abstract：:Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obs...

journal_title：Clinics in liver disease

authors： Chapin CA,Bass LM

更新日期：2018-11-01 00:00:00

abstract：:Serologic assays for HBV are the mainstay diagnostic tools for HBV infection. However, the advent of molecular biology-based techniques has added a new dimension to the diagnosis and treatment of patients with chronic HBV infection. Over the past decade, improvements in molecular technology, permitting detection of as...

journal_title：Clinics in liver disease

authors： Servoss JC,Friedman LS

更新日期：2004-05-01 00:00:00