Risk Factors for the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Including Genetics.

Abstract:

:Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovarian disease. With the introduction of genome-wide association studies, genetic mutations contributing to inherited susceptibility to steatosis have been identified, which hold keys to future improvement in diagnosis and management. This article expands on the aforementioned risk factors and summarizes the current available data on genetic and environmental factors associated with this common entity.

journal_name

Clin Liver Dis

journal_title

Clinics in liver disease

authors

Lim HW,Bernstein DE

doi

10.1016/j.cld.2017.08.008

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

39-57

issue

1

eissn

1089-3261

issn

1557-8224

pii

S1089-3261(17)30069-7

journal_volume

22

pub_type

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