Relationships among stellate cell activation, progenitor cells, and hepatic regeneration.


:Hepatic stellate cells (HSC) play an important role in liver fibrogenesis. They are also key players in liver regeneration as part of the stem cell niche of hepatocytes and hepatic progenitor cells. They produce growth stimulating and inhibiting factors for these epithelial cell compartments. In addition, recent studies suggest a role for HSCs themselves for being progenitors of epithelial cells through a transitional mesenchymal phase.


Clin Liver Dis


Clinics in liver disease


Roskams T




Has Abstract


2008-11-01 00:00:00


853-60, ix












  • Nonsteroidal anti-inflammatory drug-induced hepatotoxicity.

    abstract::Nonsteroidal anti-inflammatory drugs are among the most common drugs associated with drug-induced liver injury, with an estimated incidence of between 3 and 23 per 100,000 patient years. Nimesulide, sulindac, and diclofenac seem to be associated with the highest risk and the only risk factor consistently identified is...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Aithal GP,Day CP

    更新日期:2007-08-01 00:00:00

  • Quantitative Systems Toxicology Approaches to Understand and Predict Drug-Induced Liver Injury.

    abstract::The DILI-sim Initiative is a public-private partnership using quantitative systems toxicology to build a model (DILIsym) capable of understanding and predicting liver safety liabilities in drug candidates. The effort has provided insights into mechanisms underlying dose-dependent drug-induced liver injury (DILI) and i...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Watkins PB

    更新日期:2020-02-01 00:00:00

  • Osteoporosis.

    abstract::Osteopenia, in the form of osteoporosis, is a common complication of chronic cholestatic liver diseases and, although its cause is poorly understood, it appears to be intimately related to the cholestasis itself. With more patients surviving longer with successful liver transplantation, the clinical significance of su...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Hay JE

    更新日期:1998-05-01 00:00:00

  • Acute liver failure: a review.

    abstract::Since publication of the first descriptions of acute liver failure (ALF) as a distinct clinical entity in the 1950's, the understanding of the pathophysiologic mechanisms involved and the management options have increased substantially. ALF still represents a major challenge for todays hepatologists, because it can ra...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Khan SA,Shah N,Williams R,Jalan R

    更新日期:2006-05-01 00:00:00

  • Management complexities of HIV/hepatitis C virus coinfection in the twenty-first century.

    abstract::Because of shared routes of transmission, hepatitis C virus (HCV) coinfection is common among HIV-infected persons. Because of the effectiveness of antiretroviral therapy, chronic HCV has now emerged as a major cause of morbidity and mortality in this population. Because chronic HCV is highly prevalent among HIV-infec...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Lo Re V 3rd,Kostman JR,Amorosa VK

    更新日期:2008-08-01 00:00:00

  • Natural history of chronic hepatitis B.

    abstract::In this article, the 4 phases of chronic HBV infection are reviewed and the factors that are associated with disease progression and the development of hepatocellular carcinoma (HCC) and cirrhosis are discussed. Also discussed is what is known to date about how to identify persons at the highest risk of developing HCC...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: McMahon BJ

    更新日期:2010-08-01 00:00:00

  • Optimizing treatment regimens in hepatitis C.

    abstract::Scientists and clinicians have made tremendous advances in understanding the pathogenesis of hepatitis C virus (HCV) infection and have developed impressive strategies for treating this hepatotropic virus in the short time since its discovery in 1989. This article goes beyond the current guidelines for the treatment o...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Darling JM,Fried MW

    更新日期:2006-11-01 00:00:00

  • Expanded criteria donors.

    abstract::The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advanci...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Feng S,Lai JC

    更新日期:2014-08-01 00:00:00

  • Endoscopic retrograde cholangiopancreatography in diagnosis and treatment of primary sclerosing cholangitis.

    abstract::Primary sclerosing cholangitis is characterized by progressive fibrosing obliteration of the biliary tract. In some cases the disease is restricted to the small bile ducts, but most patients develop fibrotic stenoses of the larger bile ducts. Despite advances in magnetic resonance cholangiography, in unclear cases end...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Gotthardt D,Stiehl A

    更新日期:2010-05-01 00:00:00

  • Viral Hepatitis Other than A, B, and C: Evaluation and Management.

    abstract::Viral hepatitis can cause a wide spectrum of clinical presentations from a benign form with minimal or no symptoms to acute liver failure or death. Hepatitis D coinfection and superinfection have distinct clinical courses, with the latter more likely leading to chronic infection. Management of chronic hepatitis D viru...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Cheung A,Kwo P

    更新日期:2020-08-01 00:00:00

  • Contemporary assessment of hepatic fibrosis.

    abstract::Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Bonder A,Tapper EB,Afdhal NH

    更新日期:2015-02-01 00:00:00

  • Nutritional aspects of alcoholic liver disease.

    abstract::Development of ethanol-induced fatty liver, alcoholic hepatitis, and cirrhosis has been attributed in part to nutritional deficiencies for many years. Special attention must be focused on treating alcohol-induced liver disease while providing replacement of deficient amino acids, vitamins, minerals, and other nutrient...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Leevy CM,Moroianu SA

    更新日期:2005-02-01 00:00:00

  • Artificial liver support devices for fulminant liver failure.

    abstract::Artificial liver-support devices attempt to bridge patients with fulminant hepatic failure until either a suitable liver allograft is obtained for transplantation or the patient's own liver regenerates sufficiently to resume normal function. It is thought that toxins contribute to the clinical picture of fulminant hep...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Sechser A,Osorio J,Freise C,Osorio RW

    更新日期:2001-05-01 00:00:00

  • Chronic Hepatitis C Virus Infection and Depression.

    abstract::Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Adinolfi LE,Nevola R,Rinaldi L,Romano C,Giordano M

    更新日期:2017-08-01 00:00:00

  • Locoregional therapy of hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discuss...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Habib A,Desai K,Hickey R,Thornburg B,Lewandowski R,Salem R

    更新日期:2015-05-01 00:00:00

  • Nonviral or Drug-Induced Etiologies of Acute Liver Failure.

    abstract::Acute liver failure (ALF) is a rare but highly fatal condition. The most common causes include drug-induced and viral hepatitis, but other less common etiologies, especially autoimmune hepatitis, Budd-Chiari syndrome, and Wilson disease, need to be considered. Because diagnosis is frequently tied to potential for reve...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Rosenblatt R,Brown RS Jr

    更新日期:2018-05-01 00:00:00

  • Pathogenesis of hepatocellular carcinoma.

    abstract::The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because pathogenic host and environmental factors show significant regional variation, making such generalization difficult. Figure 4 is a model based on data...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Macdonald GA

    更新日期:2001-02-01 00:00:00

  • Noninvasive assessment of liver fibrosis.

    abstract::Understanding of the pathogenesis of hepatic fibrosis on a molecular level has led to the identification of several putative serum markers of hepatic fibrosis. Either individually or in combination, these serum markers appear capable of determining early and advanced hepatic fibrosis. Radiological determination of hep...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Kelleher TB,Afdhal N

    更新日期:2005-11-01 00:00:00

  • Primary biliary cirrhosis: the future.

    abstract::The answers to these questions are key to understanding the pathogenesis of PBC. Although the study of PBC is significantly retarded by the lack of an adequate animal model, the molecular technology to address these issues is advancing rapidly. In addition, the ability to isolate and culture human biliary epithelial c...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Mayo MJ

    更新日期:2003-11-01 00:00:00

  • Noncirrhotic portal hypertension.

    abstract::Noncirrhotic portal hypertension represents a heterogeneous group of conditions that have distinct clinical and hemodynamic features that often help distinguish them from cirrhosis. [figure: see text] The sites of portal flow resistance may not be precisely localized to one area of the hepatic lobule and may extend be...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Molina E,Reddy KR

    更新日期:2001-08-01 00:00:00

  • Antimitochondrial and other autoantibodies.

    abstract::Primary biliary cirrhosis (PBC) is characterized by the presence of high-titer disease specific autoantibodies directed against mitochondrial antigens (AMA) of the inner mitochondrial membrane, that are members of the 2-oxo acid complex. Among numerous other autoantibodies found in PBC the focus of ongoing studies is ...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Bogdanos DP,Baum H,Vergani D

    更新日期:2003-11-01 00:00:00

  • New Methods of Testing and Brain Imaging in Hepatic Encephalopathy: A Review.

    abstract::The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes. Covert hepatic encephalopathy, which is defined as abnormal performance on psychometric tests when standard neurologic examination is completely normal, has gained widespre...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Edula RG,Pyrsopoulos NT

    更新日期:2015-08-01 00:00:00

  • The use of decision analytic models to inform clinical decision making in the management of hepatocellular carcinoma.

    abstract::Decision analysis helps evaluate competing strategies under conditions of uncertainty in a wide variety of clinical settings. Despite some limitations, decision trees and Markov models remain essential tools for medical decision analysts. These techniques allow comparison of competing management strategies in a quanti...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Kim WR

    更新日期:2005-05-01 00:00:00

  • Pharmacologic Management of Hepatic Encephalopathy.

    abstract::Pharmacologic management of hepatic encephalopathy includes a broad range of therapies. This article covers the specific mainstays of therapies, such as antimicrobials and laxatives, with an established evidence base. This article also covers newer modalities of therapies, such as fecal microbiota transplant, probioti...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Mahpour NY,Pioppo-Phelan L,Reja M,Tawadros A,Rustgi VK

    更新日期:2020-05-01 00:00:00

  • Recent developments in the pathophysiology of cholestasis.

    abstract::The past decade has brought tremendous growth in the under-standing of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport proteins, the nuclear receptors that regulate them, and the potential clinic...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Hutchins GF,Gollan JL

    更新日期:2004-02-01 00:00:00

  • Autoimmune hepatitis: diagnostic criteria, subclassifications, and clinical features.

    abstract::The diagnosis of AIH depends on the finding of several suggestive features together with careful exclusion of liver diseases of other etiologies. Wherever possible, the diagnosis should be confirmed histologically by an experienced hepatopathologist. Seronegativity for the conventional autoantibodies at presentation d...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: McFarlane IG

    更新日期:2002-08-01 00:00:00

  • The Management of Hepatitis B in Liver Transplant Recipients.

    abstract::Liver transplant (LT) is now an established indication for patients with chronic hepatitis B, mainly because of the development and use of hepatitis B immunoglobulin (HBIG) and oral antivirals for prophylaxis. The combination of low-dose HBIG and antivirals has been considered the standard prophylaxis regimen to preve...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Saab S,Chen PY,Saab CE,Tong MJ

    更新日期:2016-11-01 00:00:00

  • Cholestatic liver disease overlap syndromes.

    abstract::Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis porten...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Mayo MJ

    更新日期:2013-05-01 00:00:00

  • HBV/HCV Coinfection in the Era of HCV-DAAs.

    abstract::Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular car...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Abdelaal R,Yanny B,El Kabany M

    更新日期:2019-08-01 00:00:00

  • Xenotransplantation of the liver.

    abstract::Xenotransplantation of the liver, in its broadest conception, might involve the transplantation of an intact organ or xenogeneic hepatocytes, or the use of an intact xenogeneic liver or cells as an ex vivo "device." The indications for xenotransplantation include not only hepatic failure but also, potentially, the tre...

    journal_title:Clinics in liver disease

    pub_type: 杂志文章,评审


    authors: Kanai N,Platt JL

    更新日期:2000-08-01 00:00:00