Alcohol-induced liver disease.

abstract：:The past decade has brought tremendous growth in the under-standing of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport proteins, the nuclear receptors that regulate them, and the potential clinic...

journal_title：Clinics in liver disease

authors： Hutchins GF,Gollan JL

更新日期：2004-02-01 00:00:00

abstract：:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

journal_title：Clinics in liver disease

authors： Bunchorntavakul C,Reddy KR

更新日期：2013-11-01 00:00:00

abstract：:Standard therapy with pegylated interferon and ribavirin for chronic hepatitis C is effective in 40% to 50% of individuals with genotype 1 hepatitis C virus (HCV) infection and is associated with significant treatment-related toxicities. Newly developed small molecules that target key enzymes essential for HCV replica...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2009-08-01 00:00:00

abstract：:The global risk of hepatocellular carcinoma (HCC) has been largely driven by hepatitis B virus (HBV) infection for the past century, along with hepatitis C virus (HCV), aflatoxin, excessive alcohol consumption, and obesity/diabetes. The dominant effect of HBV on global HCC risk should decline as the population vaccina...

journal_title：Clinics in liver disease

authors： McGlynn KA,London WT

更新日期：2011-05-01 00:00:00

abstract：:Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other c...

journal_title：Clinics in liver disease

authors： Gonzalez HC,Jafri SM,Gordon SC

更新日期：2017-02-01 00:00:00

abstract：:Primary sclerosing cholangitis is characterized by progressive fibrosing obliteration of the biliary tract. In some cases the disease is restricted to the small bile ducts, but most patients develop fibrotic stenoses of the larger bile ducts. Despite advances in magnetic resonance cholangiography, in unclear cases end...

journal_title：Clinics in liver disease

authors： Gotthardt D,Stiehl A

更新日期：2010-05-01 00:00:00

abstract：:Development of ethanol-induced fatty liver, alcoholic hepatitis, and cirrhosis has been attributed in part to nutritional deficiencies for many years. Special attention must be focused on treating alcohol-induced liver disease while providing replacement of deficient amino acids, vitamins, minerals, and other nutrient...

journal_title：Clinics in liver disease

authors： Leevy CM,Moroianu SA

更新日期：2005-02-01 00:00:00

abstract：:The answers to these questions are key to understanding the pathogenesis of PBC. Although the study of PBC is significantly retarded by the lack of an adequate animal model, the molecular technology to address these issues is advancing rapidly. In addition, the ability to isolate and culture human biliary epithelial c...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2003-11-01 00:00:00

abstract：:Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

journal_title：Clinics in liver disease

authors： Bonder A,Tapper EB,Afdhal NH

更新日期：2015-02-01 00:00:00

abstract：:Liver transplant (LT) is now an established indication for patients with chronic hepatitis B, mainly because of the development and use of hepatitis B immunoglobulin (HBIG) and oral antivirals for prophylaxis. The combination of low-dose HBIG and antivirals has been considered the standard prophylaxis regimen to preve...

journal_title：Clinics in liver disease

authors： Saab S,Chen PY,Saab CE,Tong MJ

更新日期：2016-11-01 00:00:00

abstract：:Abnormalities of LFTs and liver function occur not infrequently in patients with rheumatic conditions, and many diagnostic possibilities exist. Systemic inflammation that is related to uncontrolled rheumatic disease and periods of disease remission have been described as a cause for fluctuations in levels of serum ami...

journal_title：Clinics in liver disease

authors： Walker NJ,Zurier RB

更新日期：2002-11-01 00:00:00

abstract：:Since the introduction of small bowel capsule endoscopy, and more recently of esophageal capsule endoscopy, these diagnostic tools have become available for the evaluation of the consequences of portal hypertension in the esophagus, stomach, and small intestine. The main advantage of the esophageal and the small bowel...

journal_title：Clinics in liver disease

authors： Rondonotti E,Villa F,Dell' Era A,Tontini GE,de Franchis R

更新日期：2010-05-01 00:00:00

abstract：:Good management of patients at risk for the development of hepatocellular carcinoma includes regular ultrasound surveillance, and aggressive management of lesions detected at ultrasound. Good radiology and good pathology are essential to the appropriate management of these small lesions. With good quality testing it i...

journal_title：Clinics in liver disease

authors： Sherman M

更新日期：2007-11-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are among the most common drugs associated with drug-induced liver injury, with an estimated incidence of between 3 and 23 per 100,000 patient years. Nimesulide, sulindac, and diclofenac seem to be associated with the highest risk and the only risk factor consistently identified is...

journal_title：Clinics in liver disease

authors： Aithal GP,Day CP

更新日期：2007-08-01 00:00:00

abstract：:The study of hepatitis C virus (HCV) molecular virology is helping to shape the future of our anti-HCV strategies by identifying new antiviral targets. With the advent of agents that specifically target individual HCV proteins, HCV-specific therapy has arrived. Key to these efforts is the development of high-efficienc...

journal_title：Clinics in liver disease

authors： Glenn JS

更新日期：2005-08-01 00:00:00

abstract：:The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and ...

journal_title：Clinics in liver disease

authors： Bohinc BN,Diehl AM

更新日期：2012-08-01 00:00:00

abstract：:Combination therapy with beta-blockers and endoscopic band ligation (EBL) is the standard prophylaxis of esophageal variceal rebleeding in cirrhosis. Beta-blockers are the backbone of combination therapy, since their benefit extend to other complications of portal hypertension. EBL carries the risk of post-banding ulc...

journal_title：Clinics in liver disease

authors： Albillos A,Tejedor M

更新日期：2014-05-01 00:00:00

abstract：:In the intersection of alcohol ingestion with the law, medical ethics, and public safety, physicians are often unsure about how to proceed. Physicians' primary focus should be on patient education with an ethical and legal duty to warn the patient of the adverse effects of alcohol. Warning third parties of potential h...

journal_title：Clinics in liver disease

authors： Balakrishnan M,Pappas SC

更新日期：2019-02-01 00:00:00

abstract：:The dual blood supply of the liver, originating from the portal vein and the hepatic artery, makes it relatively resistant to minor circulatory disturbances. However, hepatic manifestations of common cardiovascular disorders are frequently encountered in both the inpatient and outpatient setting. Beginning with the ma...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2011-02-01 00:00:00

abstract：:Biochemical cholestasis after liver transplantation is common and often has no clinical significance if biliary anastomosis strictures and leaks have been excluded. There is no agreed upon definition for severe cholestasis, but it is associated with a worse mortality. There has been little evaluation on risk factors, ...

journal_title：Clinics in liver disease

authors： Corbani A,Burroughs AK

更新日期：2008-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovari...

journal_title：Clinics in liver disease

authors： Lim HW,Bernstein DE

更新日期：2018-02-01 00:00:00

abstract：:Primary liver cancer is the fifth most common malignancy worldwide and the third leading cause of cancer mortality. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the United States encompassing a spectrum of entities marked by hepatic steatosis in the absence of significant alco...

journal_title：Clinics in liver disease

authors： Page JM,Harrison SA

更新日期：2009-11-01 00:00:00

abstract：:Decision analysis helps evaluate competing strategies under conditions of uncertainty in a wide variety of clinical settings. Despite some limitations, decision trees and Markov models remain essential tools for medical decision analysts. These techniques allow comparison of competing management strategies in a quanti...

journal_title：Clinics in liver disease

authors： Kim WR

更新日期：2005-05-01 00:00:00

abstract：:Early diagnosis of HCC is possible because certain risk factors for this tumor are known and because sensitive and relatively inexpensive diagnostic tools are available. Early diagnosis of HCC is also possible because of the long phase of asymptomatic tumor growth and the tumor's tendency to grow as a solitary mass in...

journal_title：Clinics in liver disease

authors： Colombo M

更新日期：2001-02-01 00:00:00

abstract：:Recurrent autoimmune hepatitis (AIH) and de novo AIH are 2 important causes of late graft failure after liver transplantation (LT). Recurrent AIH occurs in patients who undergo LT for AIH. De novo AIH occurs in patients who are transplanted for etiologies other than AIH. Although typically treated with standard treatm...

journal_title：Clinics in liver disease

authors： Beal EW,Black SM,Michaels A

更新日期：2017-05-01 00:00:00

abstract：:The risk for potential transmission of infectious agents during gastrointestinal (GI) endoscopy is concerning for patients and physicians. However, the instance of infection transmission remains rare after GI endoscopy procedures, with an estimated frequency of 1 in 1.8 million procedures. Endoscopy-related infection ...

journal_title：Clinics in liver disease

authors： Wu H,Shen B

更新日期：2010-02-01 00:00:00

abstract：:Pruritus is a common symptom with primary biliary cholangitis. Research has focused on refining understanding of the neurohumoral pathways involved in transduction of pruritus from peripheral cutaneous receptors to the central nervous system, and identifying modulating drugs. Current treatments have variable efficacy ...

journal_title：Clinics in liver disease

authors： Carrion AF,Rosen JD,Levy C

更新日期：2018-08-01 00:00:00

abstract：:Although hepatic encephalopathy (HE) is prevalent in the cirrhotic population, it has also been considered a potentially reversible condition. Liver transplantation represents the ultimate reversal of the decompensated cirrhotic state and should provide the best option for the reversibility of HE. However, the neurolo...

journal_title：Clinics in liver disease

authors： Frederick RT

更新日期：2012-02-01 00:00:00

abstract：:Understanding of the pathogenesis of hepatic fibrosis on a molecular level has led to the identification of several putative serum markers of hepatic fibrosis. Either individually or in combination, these serum markers appear capable of determining early and advanced hepatic fibrosis. Radiological determination of hep...

journal_title：Clinics in liver disease

authors： Kelleher TB,Afdhal N

更新日期：2005-11-01 00:00:00

abstract：:For patients who present with variceal bleeding refractory to endoscopic and pharmacologic methods, TIPS is a new and effective therapy. Stents are used in selected patients with decompensated liver disease and those who anticipate liver transplantation within 6 to 12 months. Surveillance of TIPS with ultrasound, with...

journal_title：Clinics in liver disease

authors： Faust TW,Sorrell MF

更新日期：1997-05-01 00:00:00