Nutritional aspects of alcoholic liver disease.

abstract：:Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New inf...

journal_title：Clinics in liver disease

authors： McGlynn KA,Petrick JL,London WT

更新日期：2015-05-01 00:00:00

abstract：:The incidence of newly acquired hepatitis C infection has diminished in the United States. This decline is largely because of a decrease in cases among IDUs for reasons that are unclear and, to a lesser extent, to testing of blood donors for HCV. The virus is transmitted by blood, and such transmission now occurs prim...

journal_title：Clinics in liver disease

authors： Seeff LB,Hoofnagle JH

更新日期：2003-02-01 00:00:00

abstract：:Since the introduction of small bowel capsule endoscopy, and more recently of esophageal capsule endoscopy, these diagnostic tools have become available for the evaluation of the consequences of portal hypertension in the esophagus, stomach, and small intestine. The main advantage of the esophageal and the small bowel...

journal_title：Clinics in liver disease

authors： Rondonotti E,Villa F,Dell' Era A,Tontini GE,de Franchis R

更新日期：2010-05-01 00:00:00

abstract：:Primary biliary cirrhosis is an insidious disease that progresses through the clinical phases: preclinical, asymptomatic, symptomatic, and liver insufficiency. The outlook of patients diagnosed with PBC has improved significantly over the past 2 decades because more patients are being diagnosed earlier in the disease ...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2008-05-01 00:00:00

abstract：:The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advanci...

journal_title：Clinics in liver disease

authors： Feng S,Lai JC

更新日期：2014-08-01 00:00:00

abstract：:Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis porten...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2013-05-01 00:00:00

abstract：:Renal dysfunction is a frequent complication in patients with endstage liver disease awaiting orthotopic liver transplantation. Although the stereotypical form of renal dysfunction is the hepatorenal syndrome, common causes of acute kidney injury include prerenal azotemia and acute tubular necrosis in this population....

journal_title：Clinics in liver disease

authors： Lau C,Martin P,Bunnapradist S

更新日期：2011-11-01 00:00:00

abstract：:Biochemical cholestasis after liver transplantation is common and often has no clinical significance if biliary anastomosis strictures and leaks have been excluded. There is no agreed upon definition for severe cholestasis, but it is associated with a worse mortality. There has been little evaluation on risk factors, ...

journal_title：Clinics in liver disease

authors： Corbani A,Burroughs AK

更新日期：2008-02-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are examples of complex diseases accompanied by changes in the expression of thousands of genes and a plethora of proteins encoded by these genes. Before the era of high-throughput analysis, typical translational research initiatives, a...

journal_title：Clinics in liver disease

authors： Baranova A,Liotta L,Petricoin E,Younossi ZM

更新日期：2007-02-01 00:00:00

abstract：:The past decade has brought tremendous growth in the under-standing of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport proteins, the nuclear receptors that regulate them, and the potential clinic...

journal_title：Clinics in liver disease

authors： Hutchins GF,Gollan JL

更新日期：2004-02-01 00:00:00

abstract：:It is no secret that the health care environment today is motivated by the underlying, largely economic impetus of managed care. This is particularly evident within the organ transplantation community, where third party payers hope to minimize their financial risk by relying more and more on "centers of excellence" ne...

journal_title：Clinics in liver disease

authors： Evans RW,Kitzmann DJ

更新日期：1997-08-01 00:00:00

abstract：:The most consistently identified predictive factors for a response to both IFN-alpha monotherapy and IFN-alpha in combination with ribavirin are a low HCV RNA level, the absence of fibrosis, infection with HCV genotype 2 and 3, and a prolonged duration of treatment. In addition, an early response to IFN-alpha predicts...

journal_title：Clinics in liver disease

authors： Barnes E,Webster G,Whalley S,Dusheiko G

更新日期：1999-11-01 00:00:00

abstract：:The dual blood supply of the liver, originating from the portal vein and the hepatic artery, makes it relatively resistant to minor circulatory disturbances. However, hepatic manifestations of common cardiovascular disorders are frequently encountered in both the inpatient and outpatient setting. Beginning with the ma...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2011-02-01 00:00:00

abstract：:Although hepatic encephalopathy (HE) is prevalent in the cirrhotic population, it has also been considered a potentially reversible condition. Liver transplantation represents the ultimate reversal of the decompensated cirrhotic state and should provide the best option for the reversibility of HE. However, the neurolo...

journal_title：Clinics in liver disease

authors： Frederick RT

更新日期：2012-02-01 00:00:00

abstract：:The DILI-sim Initiative is a public-private partnership using quantitative systems toxicology to build a model (DILIsym) capable of understanding and predicting liver safety liabilities in drug candidates. The effort has provided insights into mechanisms underlying dose-dependent drug-induced liver injury (DILI) and i...

journal_title：Clinics in liver disease

authors： Watkins PB

更新日期：2020-02-01 00:00:00

abstract：:Although recent evidence indicates that the quasispecies nature of HCV constitutes a critical strategy for the virus to survive in the host, the mechanisms of viral persistence remain unknown. Similarly, the correlates of immune protection in a limited proportion of individuals who succeed in clearing HCV are still la...

journal_title：Clinics in liver disease

authors： Farci P

更新日期：2001-11-01 00:00:00

abstract：:Liver dysfunction is common in both the critically ill and postoperative patient. Metabolic derangements secondary to sepsis, poor hepatic perfusion, total parenteral nutrition, in addition to hemodynamic and anesthetic-induced changes that occur during surgery, can cause liver damage ranging from small self-limited a...

journal_title：Clinics in liver disease

authors： Aronsohn A,Jensen D

更新日期：2011-02-01 00:00:00

abstract：:In conclusion, the natural history of chronic HCV infection has not yet been fully defined. Current data suggest that the process runs an indolent course during the first two decades after initial infection, accounting for modest morbidity and mortality. Serious sequelae are more likely to emerge as the disease proces...

journal_title：Clinics in liver disease

authors： Seeff LB

更新日期：1997-11-01 00:00:00

abstract：:Acute liver failure (ALF) is a rare but highly fatal condition. The most common causes include drug-induced and viral hepatitis, but other less common etiologies, especially autoimmune hepatitis, Budd-Chiari syndrome, and Wilson disease, need to be considered. Because diagnosis is frequently tied to potential for reve...

journal_title：Clinics in liver disease

authors： Rosenblatt R,Brown RS Jr

更新日期：2018-05-01 00:00:00

abstract：:Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

journal_title：Clinics in liver disease

authors： Bonder A,Tapper EB,Afdhal NH

更新日期：2015-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovari...

journal_title：Clinics in liver disease

authors： Lim HW,Bernstein DE

更新日期：2018-02-01 00:00:00

abstract：:The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes. Covert hepatic encephalopathy, which is defined as abnormal performance on psychometric tests when standard neurologic examination is completely normal, has gained widespre...

journal_title：Clinics in liver disease

authors： Edula RG,Pyrsopoulos NT

更新日期：2015-08-01 00:00:00

abstract：:Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular car...

journal_title：Clinics in liver disease

authors： Abdelaal R,Yanny B,El Kabany M

更新日期：2019-08-01 00:00:00

abstract：:Understanding of the pathogenesis of hepatic fibrosis on a molecular level has led to the identification of several putative serum markers of hepatic fibrosis. Either individually or in combination, these serum markers appear capable of determining early and advanced hepatic fibrosis. Radiological determination of hep...

journal_title：Clinics in liver disease

authors： Kelleher TB,Afdhal N

更新日期：2005-11-01 00:00:00

abstract：:Decision analysis helps evaluate competing strategies under conditions of uncertainty in a wide variety of clinical settings. Despite some limitations, decision trees and Markov models remain essential tools for medical decision analysts. These techniques allow comparison of competing management strategies in a quanti...

journal_title：Clinics in liver disease

authors： Kim WR

更新日期：2005-05-01 00:00:00

abstract：:Pruritus is a common symptom with primary biliary cholangitis. Research has focused on refining understanding of the neurohumoral pathways involved in transduction of pruritus from peripheral cutaneous receptors to the central nervous system, and identifying modulating drugs. Current treatments have variable efficacy ...

journal_title：Clinics in liver disease

authors： Carrion AF,Rosen JD,Levy C

更新日期：2018-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observ...

journal_title：Clinics in liver disease

authors： Adinolfi LE,Nevola R,Rinaldi L,Romano C,Giordano M

更新日期：2017-08-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is recognized as a global health problem and as a common cause of chronic liver disease. Nonalcoholic steatohepatitis (NASH) carries an increased risk for development of advanced liver disease. Lifestyle modifications with diet and exercise have been the initial management reco...

journal_title：Clinics in liver disease

authors： Golabi P,Bush H,Younossi ZM

更新日期：2017-11-01 00:00:00

abstract：:Early diagnosis of HCC is possible because certain risk factors for this tumor are known and because sensitive and relatively inexpensive diagnostic tools are available. Early diagnosis of HCC is also possible because of the long phase of asymptomatic tumor growth and the tumor's tendency to grow as a solitary mass in...

journal_title：Clinics in liver disease

authors： Colombo M

更新日期：2001-02-01 00:00:00

abstract：:Bile acid synthetic defects are uncommon disorders that cause progressive cholestatic liver disease that is often lethal in infancy or early childhood. Five specific primary defects have been described. Diagnosis is based on mass spectrometry of urine and serum. Pathogenesis of liver injury is related to persistent re...

journal_title：Clinics in liver disease

authors： Bove KE

更新日期：2000-11-01 00:00:00