Abstract:
:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence the susceptibility and severity of APAP hepatotoxicity. Early manifestations of APAP hepatotoxicity are nonspecific, but require prompt recognition by physicians. Patients with repeated overdose tend to present late, and in such hepatotoxicity may have already evolved. N-acetylcysteine is a very effective antidote when giving within 8 hours, and is also recommended after a presentation of hepatotoxicity and ALF. The prognosis of patients with APAP-induced ALF is better than other causes of ALF. Liver transplantation should be offered to those who are unlikely to survive.
journal_name
Clin Liver Disjournal_title
Clinics in liver diseaseauthors
Bunchorntavakul C,Reddy KRdoi
10.1016/j.cld.2013.07.005subject
Has Abstractpub_date
2013-11-01 00:00:00pages
587-607, viiiissue
4eissn
1089-3261issn
1557-8224pii
S1089-3261(13)00034-2journal_volume
17pub_type
杂志文章,评审abstract::The dual blood supply of the liver, originating from the portal vein and the hepatic artery, makes it relatively resistant to minor circulatory disturbances. However, hepatic manifestations of common cardiovascular disorders are frequently encountered in both the inpatient and outpatient setting. Beginning with the ma...
journal_title:Clinics in liver disease
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journal_title:Clinics in liver disease
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Clinics in liver disease
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2014.09.007
更新日期:2015-02-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2004.12.004
更新日期:2005-05-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2009.11.012
更新日期:2010-02-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:1997-11-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2018.03.005
更新日期:2018-08-01 00:00:00
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journal_title:Clinics in liver disease
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doi:10.1016/j.cld.2004.11.003
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2016.02.006
更新日期:2016-08-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
doi:10.1016/j.cld.2018.12.012
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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journal_title:Clinics in liver disease
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journal_title:Clinics in liver disease
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abstract::Renal dysfunction is a frequent complication in patients with endstage liver disease awaiting orthotopic liver transplantation. Although the stereotypical form of renal dysfunction is the hepatorenal syndrome, common causes of acute kidney injury include prerenal azotemia and acute tubular necrosis in this population....
journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Clinics in liver disease
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abstract::In this article, the 4 phases of chronic HBV infection are reviewed and the factors that are associated with disease progression and the development of hepatocellular carcinoma (HCC) and cirrhosis are discussed. Also discussed is what is known to date about how to identify persons at the highest risk of developing HCC...
journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
abstract::Combination therapy with beta-blockers and endoscopic band ligation (EBL) is the standard prophylaxis of esophageal variceal rebleeding in cirrhosis. Beta-blockers are the backbone of combination therapy, since their benefit extend to other complications of portal hypertension. EBL carries the risk of post-banding ulc...
journal_title:Clinics in liver disease
pub_type: 杂志文章,评审
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