Telaprevir: hope on the horizon, getting closer.

abstract：:In summary, re-OLT accounts for 10% of all OLTs performed and is associated with significantly increased resource use, and decreased survival compared with primary OLT. After transplantation into an HCV-infected recipient, infection of the allograft by HCV is invariable. As patients survive longer after liver transpla...

journal_title：Clinics in liver disease

authors： Forman LM

更新日期：2003-08-01 00:00:00

abstract：:Since publication of the first descriptions of acute liver failure (ALF) as a distinct clinical entity in the 1950's, the understanding of the pathophysiologic mechanisms involved and the management options have increased substantially. ALF still represents a major challenge for todays hepatologists, because it can ra...

journal_title：Clinics in liver disease

authors： Khan SA,Shah N,Williams R,Jalan R

更新日期：2006-05-01 00:00:00

abstract：:Viral hepatitis can cause a wide spectrum of clinical presentations from a benign form with minimal or no symptoms to acute liver failure or death. Hepatitis D coinfection and superinfection have distinct clinical courses, with the latter more likely leading to chronic infection. Management of chronic hepatitis D viru...

journal_title：Clinics in liver disease

authors： Cheung A,Kwo P

更新日期：2020-08-01 00:00:00

abstract：:Combination therapy with beta-blockers and endoscopic band ligation (EBL) is the standard prophylaxis of esophageal variceal rebleeding in cirrhosis. Beta-blockers are the backbone of combination therapy, since their benefit extend to other complications of portal hypertension. EBL carries the risk of post-banding ulc...

journal_title：Clinics in liver disease

authors： Albillos A,Tejedor M

更新日期：2014-05-01 00:00:00

abstract：:Obesity has become increasingly prevalent, and the number of obese patients in need of liver transplant is expected to continue to increase. In addition, liver disease due to nonalcoholic fatty liver disease is expected to become the leading cause of liver transplantation in the near future. However, obesity remains a...

journal_title：Clinics in liver disease

authors： Suraweera D,Dutson E,Saab S

更新日期：2017-05-01 00:00:00

abstract：:Hepatotoxicity associated with any antibiotic is rare. With the wide-spread use of antimicrobial agents, however, hepatic injury is not an infrequent occurrence. Penicillins remain a widely used class of antimicrobials with a well defined record of low hepatotoxicity. The combination of clavulanate with amoxicillin ma...

journal_title：Clinics in liver disease

authors： Thiim M,Friedman LS

更新日期：2003-05-01 00:00:00

abstract：:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

journal_title：Clinics in liver disease

authors： Bunchorntavakul C,Reddy KR

更新日期：2013-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD fir...

journal_title：Clinics in liver disease

authors： Kleiner DE,Makhlouf HR

更新日期：2016-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is common and may progress to end-stage liver disease. Liver-related morbidity and mortality occur almost exclusively in patients whose disease progresses to advanced fibrosis and cirrhosis. Presence and severity of liver fibrosis seem the most important indicators of long-ter...

journal_title：Clinics in liver disease

authors： Adams LA,Angulo P

更新日期：2007-02-01 00:00:00

abstract：:Early diagnosis of HCC is possible because certain risk factors for this tumor are known and because sensitive and relatively inexpensive diagnostic tools are available. Early diagnosis of HCC is also possible because of the long phase of asymptomatic tumor growth and the tumor's tendency to grow as a solitary mass in...

journal_title：Clinics in liver disease

authors： Colombo M

更新日期：2001-02-01 00:00:00

abstract：:Although several mouse models of AIH have been described, no model is ideal. Indeed, the disease is self-limited in each model, and none is associated with significant liver fibrosis or progression to cirrhosis. Nevertheless, these models should be useful for testing different hypotheses regarding the initiation of AI...

journal_title：Clinics in liver disease

authors： Howell CD

更新日期：2002-08-01 00:00:00

abstract：:Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New inf...

journal_title：Clinics in liver disease

authors： McGlynn KA,Petrick JL,London WT

更新日期：2015-05-01 00:00:00

abstract：:It is no secret that the health care environment today is motivated by the underlying, largely economic impetus of managed care. This is particularly evident within the organ transplantation community, where third party payers hope to minimize their financial risk by relying more and more on "centers of excellence" ne...

journal_title：Clinics in liver disease

authors： Evans RW,Kitzmann DJ

更新日期：1997-08-01 00:00:00

abstract：:Nonalcoholic fatty liver disease is emerging as the most common cause of chronic liver disease worldwide. This trend is, in part, secondary, to the growing incidence of obesity, type 2 diabetes, and metabolic syndrome. Other risk factors include age, gender, race/ethnicity, genetic predisposition, and polycystic ovari...

journal_title：Clinics in liver disease

authors： Lim HW,Bernstein DE

更新日期：2018-02-01 00:00:00

abstract：:Serologic assays for HBV are the mainstay diagnostic tools for HBV infection. However, the advent of molecular biology-based techniques has added a new dimension to the diagnosis and treatment of patients with chronic HBV infection. Over the past decade, improvements in molecular technology, permitting detection of as...

journal_title：Clinics in liver disease

authors： Servoss JC,Friedman LS

更新日期：2004-05-01 00:00:00

abstract：:Since the introduction of small bowel capsule endoscopy, and more recently of esophageal capsule endoscopy, these diagnostic tools have become available for the evaluation of the consequences of portal hypertension in the esophagus, stomach, and small intestine. The main advantage of the esophageal and the small bowel...

journal_title：Clinics in liver disease

authors： Rondonotti E,Villa F,Dell' Era A,Tontini GE,de Franchis R

更新日期：2010-05-01 00:00:00

abstract：:Bile acid synthetic defects are uncommon disorders that cause progressive cholestatic liver disease that is often lethal in infancy or early childhood. Five specific primary defects have been described. Diagnosis is based on mass spectrometry of urine and serum. Pathogenesis of liver injury is related to persistent re...

journal_title：Clinics in liver disease

authors： Bove KE

更新日期：2000-11-01 00:00:00

abstract：:A variety of benign and malignant neoplasms can be encountered in the liver. Hematoxylin and eosin-stained tissue sections alone may not yield sufficient information to definitively diagnose liver tumors; therefore, ancillary studies with immunohistochemical markers can play a crucial role in differentiating the diffe...

journal_title：Clinics in liver disease

authors： Chan ES,Yeh MM

更新日期：2010-11-01 00:00:00

abstract：:This article reviews the spectrum of alcohol use disorders. The pharmacologic properties of ethanol and its metabolism, and the historical, physical, and laboratory elements that may help diagnose an alcohol use disorder are examined. The concepts of motivational interviewing and stages of change are mentioned, along ...

journal_title：Clinics in liver disease

authors： Albanese AP

更新日期：2012-11-01 00:00:00

abstract：:The greatest challenge facing liver transplantation today is the shortage of donor livers. Demand far exceeds supply, and this deficit has driven expansion of what is considered an acceptable organ. The evolving standard has not come without costs, however, as each new frontier of expanded donor quality (i.e., advanci...

journal_title：Clinics in liver disease

authors： Feng S,Lai JC

更新日期：2014-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observ...

journal_title：Clinics in liver disease

authors： Adinolfi LE,Nevola R,Rinaldi L,Romano C,Giordano M

更新日期：2017-08-01 00:00:00

abstract：:The study of hepatitis C virus (HCV) molecular virology is helping to shape the future of our anti-HCV strategies by identifying new antiviral targets. With the advent of agents that specifically target individual HCV proteins, HCV-specific therapy has arrived. Key to these efforts is the development of high-efficienc...

journal_title：Clinics in liver disease

authors： Glenn JS

更新日期：2005-08-01 00:00:00

abstract：:Good management of patients at risk for the development of hepatocellular carcinoma includes regular ultrasound surveillance, and aggressive management of lesions detected at ultrasound. Good radiology and good pathology are essential to the appropriate management of these small lesions. With good quality testing it i...

journal_title：Clinics in liver disease

authors： Sherman M

更新日期：2007-11-01 00:00:00

abstract：:Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis porten...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2013-05-01 00:00:00

abstract：:Current prophylactic measures have greatly reduced recurrence rates of hepatitis B after liver transplantation. HBIG remains a critically important compound and although there is variability in dosing regimens and target anti-HBs levels, it is the backbone of recurrence prevention. Adjuvant therapies with nucleoside/n...

journal_title：Clinics in liver disease

authors： Poordad FF

更新日期：2004-05-01 00:00:00

abstract：:Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other c...

journal_title：Clinics in liver disease

authors： Gonzalez HC,Jafri SM,Gordon SC

更新日期：2017-02-01 00:00:00

abstract：:This article introduces one of the most diverse classes of direct-acting antivirals for hepatitis C, the nucleoside and non-nucleoside NS5B polymerase inhibitors. Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectivenes...

journal_title：Clinics in liver disease

authors： Membreno FE,Lawitz EJ

更新日期：2011-08-01 00:00:00

abstract：:The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because pathogenic host and environmental factors show significant regional variation, making such generalization difficult. Figure 4 is a model based on data...

journal_title：Clinics in liver disease

authors： Macdonald GA

更新日期：2001-02-01 00:00:00

abstract：:Renal dysfunction is a frequent complication in patients with endstage liver disease awaiting orthotopic liver transplantation. Although the stereotypical form of renal dysfunction is the hepatorenal syndrome, common causes of acute kidney injury include prerenal azotemia and acute tubular necrosis in this population....

journal_title：Clinics in liver disease

authors： Lau C,Martin P,Bunnapradist S

更新日期：2011-11-01 00:00:00

abstract：:Noncirrhotic portal hypertension represents a heterogeneous group of conditions that have distinct clinical and hemodynamic features that often help distinguish them from cirrhosis. [figure: see text] The sites of portal flow resistance may not be precisely localized to one area of the hepatic lobule and may extend be...

journal_title：Clinics in liver disease

authors： Molina E,Reddy KR

更新日期：2001-08-01 00:00:00