Role of liver biopsy and serum markers of liver fibrosis in non-alcoholic fatty liver disease.

abstract：:Nonsteroidal anti-inflammatory drugs are among the most common drugs associated with drug-induced liver injury, with an estimated incidence of between 3 and 23 per 100,000 patient years. Nimesulide, sulindac, and diclofenac seem to be associated with the highest risk and the only risk factor consistently identified is...

journal_title：Clinics in liver disease

authors： Aithal GP,Day CP

更新日期：2007-08-01 00:00:00

abstract：:The metabolic syndrome and the hepatitis C virus (HCV) infection are 2 global health care challenges with a complex interaction. Insulin resistance, a central component of the metabolic syndrome, is epidemiologically and pathophysiologically intrinsically linked to HCV infection. Insulin resistance and diabetes affect...

journal_title：Clinics in liver disease

authors： Goossens N,Negro F

更新日期：2014-02-01 00:00:00

abstract：:Pharmacologic management of hepatic encephalopathy includes a broad range of therapies. This article covers the specific mainstays of therapies, such as antimicrobials and laxatives, with an established evidence base. This article also covers newer modalities of therapies, such as fecal microbiota transplant, probioti...

journal_title：Clinics in liver disease

authors： Mahpour NY,Pioppo-Phelan L,Reja M,Tawadros A,Rustgi VK

更新日期：2020-05-01 00:00:00

abstract：:Good management of patients at risk for the development of hepatocellular carcinoma includes regular ultrasound surveillance, and aggressive management of lesions detected at ultrasound. Good radiology and good pathology are essential to the appropriate management of these small lesions. With good quality testing it i...

journal_title：Clinics in liver disease

authors： Sherman M

更新日期：2007-11-01 00:00:00

abstract：:Primary liver cancer is the fifth most common malignancy worldwide and the third leading cause of cancer mortality. Non-alcoholic fatty liver disease is the most common cause of chronic liver disease in the United States encompassing a spectrum of entities marked by hepatic steatosis in the absence of significant alco...

journal_title：Clinics in liver disease

authors： Page JM,Harrison SA

更新日期：2009-11-01 00:00:00

abstract：:Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discuss...

journal_title：Clinics in liver disease

authors： Habib A,Desai K,Hickey R,Thornburg B,Lewandowski R,Salem R

更新日期：2015-05-01 00:00:00

abstract：:Patients with sickle cell disease can develop liver disease as a result of intrahepatic sickling of erythrocytes, viral hepatitis and iron overload secondary to multiple blood transfusions, and gallstone disease as a result of chronic hemolysis. The spectrum of clinical liver disease is wide and often multifactorial. ...

journal_title：Clinics in liver disease

authors： Theocharidou E,Suddle AR

更新日期：2019-05-01 00:00:00

abstract：:Early diagnosis of HCC is possible because certain risk factors for this tumor are known and because sensitive and relatively inexpensive diagnostic tools are available. Early diagnosis of HCC is also possible because of the long phase of asymptomatic tumor growth and the tumor's tendency to grow as a solitary mass in...

journal_title：Clinics in liver disease

authors： Colombo M

更新日期：2001-02-01 00:00:00

abstract：:Nonalcoholic fatty liver (NAFL) is increasingly recognized as an important and common public health problem that can lead to cirrhosis and hepatic failure. Because it is often asymptomatic,many people may not know that they have it. NAFL is closely linked to obesity, which in the United States and other developed coun...

journal_title：Clinics in liver disease

authors： Ruhl CE,Everhart JE

更新日期：2004-08-01 00:00:00

abstract：:Artificial liver-support devices attempt to bridge patients with fulminant hepatic failure until either a suitable liver allograft is obtained for transplantation or the patient's own liver regenerates sufficiently to resume normal function. It is thought that toxins contribute to the clinical picture of fulminant hep...

journal_title：Clinics in liver disease

authors： Sechser A,Osorio J,Freise C,Osorio RW

更新日期：2001-05-01 00:00:00

abstract：:Both covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE) impair the ability to operate machinery. The legal responsibilities of US physicians who diagnose and treat patients with hepatic encephalopathy vary among states. It is imperative that physicians know the laws regarding reporting in their...

journal_title：Clinics in liver disease

authors： Vierling JM

更新日期：2015-08-01 00:00:00

abstract：:Noncirrhotic portal hypertension represents a heterogeneous group of conditions that have distinct clinical and hemodynamic features that often help distinguish them from cirrhosis. [figure: see text] The sites of portal flow resistance may not be precisely localized to one area of the hepatic lobule and may extend be...

journal_title：Clinics in liver disease

authors： Molina E,Reddy KR

更新日期：2001-08-01 00:00:00

abstract：:Liver biopsy is used to determine the pathogenesis of liver dysfunction after liver transplantation. One or more causative factors may be identified on biopsy. The pathologist must be familiar with the histopathology of acute rejection to differentiate it from other potential complications, including biliary obstructi...

journal_title：Clinics in liver disease

authors： Lefkowitch JH

更新日期：2002-05-01 00:00:00

abstract：:Although hepatic encephalopathy (HE) is prevalent in the cirrhotic population, it has also been considered a potentially reversible condition. Liver transplantation represents the ultimate reversal of the decompensated cirrhotic state and should provide the best option for the reversibility of HE. However, the neurolo...

journal_title：Clinics in liver disease

authors： Frederick RT

更新日期：2012-02-01 00:00:00

abstract：:The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because pathogenic host and environmental factors show significant regional variation, making such generalization difficult. Figure 4 is a model based on data...

journal_title：Clinics in liver disease

authors： Macdonald GA

更新日期：2001-02-01 00:00:00

abstract：:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

journal_title：Clinics in liver disease

authors： Bunchorntavakul C,Reddy KR

更新日期：2013-11-01 00:00:00

abstract：:Autoimmune liver diseases have much in common with each other, and there are clear associations with genetic haplotypes. Elegant studies have shown autoimmune liver disease induced by viruses and drugs. Although there is evidence for nonimmunological events precipitating immune disease, especially in primary sclerosin...

journal_title：Clinics in liver disease

authors： Peters MG

更新日期：1998-05-01 00:00:00

abstract：:Drug-induced liver injury (DILI) can be predictable or idiosyncratic and has an estimated incidence of approximately 20 cases per 100,000 persons per year. DILI is a common cause of acute liver failure in the United States. No accurate tests for diagnosing DILI exist, and its diagnosis is based on exclusion of other c...

journal_title：Clinics in liver disease

authors： Gonzalez HC,Jafri SM,Gordon SC

更新日期：2017-02-01 00:00:00

abstract：:Biochemical cholestasis after liver transplantation is common and often has no clinical significance if biliary anastomosis strictures and leaks have been excluded. There is no agreed upon definition for severe cholestasis, but it is associated with a worse mortality. There has been little evaluation on risk factors, ...

journal_title：Clinics in liver disease

authors： Corbani A,Burroughs AK

更新日期：2008-02-01 00:00:00

abstract：:Although recent evidence indicates that the quasispecies nature of HCV constitutes a critical strategy for the virus to survive in the host, the mechanisms of viral persistence remain unknown. Similarly, the correlates of immune protection in a limited proportion of individuals who succeed in clearing HCV are still la...

journal_title：Clinics in liver disease

authors： Farci P

更新日期：2001-11-01 00:00:00

abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure used in the management of complications of portal hypertension. Although the most robust evidence supports the use of TIPS as salvage therapy in variceal hemorrhage, secondary prophylaxis of variceal bleeding, and treatment of refract...

journal_title：Clinics in liver disease

authors： Hung ML,Lee EW

更新日期：2019-11-01 00:00:00

abstract：:Since the introduction of small bowel capsule endoscopy, and more recently of esophageal capsule endoscopy, these diagnostic tools have become available for the evaluation of the consequences of portal hypertension in the esophagus, stomach, and small intestine. The main advantage of the esophageal and the small bowel...

journal_title：Clinics in liver disease

authors： Rondonotti E,Villa F,Dell' Era A,Tontini GE,de Franchis R

更新日期：2010-05-01 00:00:00

abstract：:Primary biliary cirrhosis and primary sclerosing cholangitis share some clinical features with autoimmune hepatitis, but when features of autoimmune hepatitis are present, prognosis can be affected and immunosuppressive treatment warranted. The presence of severe interface hepatitis in primary biliary cirrhosis porten...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2013-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder that can be divided into benign steatosis or nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Elastography and scoring systems based on clinical features and routine biochemical testing can be used to assess fibrosis in patient...

journal_title：Clinics in liver disease

authors： Gunn NT,Shiffman ML

更新日期：2018-02-01 00:00:00

abstract：:Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New inf...

journal_title：Clinics in liver disease

authors： McGlynn KA,Petrick JL,London WT

更新日期：2015-05-01 00:00:00

abstract：:With obesity reaching epidemic proportions in the United States, it is imperative that hepatologists have an understanding of the medical ramifications and methods of treatment. Evaluation of nonalcoholic fatty liver disease may get the patient into the office,but weight reduction may provide a therapeutic hurdle. Thi...

journal_title：Clinics in liver disease

authors： Bouneva I,Kirby DF

更新日期：2004-08-01 00:00:00

abstract：:Patients with hepatocellular carcinoma (HCC) have many treatment options. For patients with surgical indication, consideration of future liver remnant and the surgical complexity of the procedure is essential. A new 3-level complexity classification categorizing 11 liver resection procedures predicts surgical complexi...

journal_title：Clinics in liver disease

authors： Kawaguchi Y,Lillemoe HA,Vauthey JN

更新日期：2020-11-01 00:00:00

abstract：:In the past two decades, pediatric liver transplantation has become the state-of-the-art operation with anticipated success and limited mortality. The future success of pediatric liver transplantation will require thoughtful solutions to the delicate balance of risk to donors and recipients, the complex needs of the a...

journal_title：Clinics in liver disease

authors： Tiao G,Ryckman FC

更新日期：2006-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD fir...

journal_title：Clinics in liver disease

authors： Kleiner DE,Makhlouf HR

更新日期：2016-05-01 00:00:00

abstract：:Liver dysfunction is common in both the critically ill and postoperative patient. Metabolic derangements secondary to sepsis, poor hepatic perfusion, total parenteral nutrition, in addition to hemodynamic and anesthetic-induced changes that occur during surgery, can cause liver damage ranging from small self-limited a...

journal_title：Clinics in liver disease

authors： Aronsohn A,Jensen D

更新日期：2011-02-01 00:00:00