Diagnostic issues in liver transplantation pathology.

abstract：:This article reviews the spectrum of alcohol use disorders. The pharmacologic properties of ethanol and its metabolism, and the historical, physical, and laboratory elements that may help diagnose an alcohol use disorder are examined. The concepts of motivational interviewing and stages of change are mentioned, along ...

journal_title：Clinics in liver disease

authors： Albanese AP

更新日期：2012-11-01 00:00:00

abstract：:Patients with hepatocellular carcinoma (HCC) have many treatment options. For patients with surgical indication, consideration of future liver remnant and the surgical complexity of the procedure is essential. A new 3-level complexity classification categorizing 11 liver resection procedures predicts surgical complexi...

journal_title：Clinics in liver disease

authors： Kawaguchi Y,Lillemoe HA,Vauthey JN

更新日期：2020-11-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is common and may progress to end-stage liver disease. Liver-related morbidity and mortality occur almost exclusively in patients whose disease progresses to advanced fibrosis and cirrhosis. Presence and severity of liver fibrosis seem the most important indicators of long-ter...

journal_title：Clinics in liver disease

authors： Adams LA,Angulo P

更新日期：2007-02-01 00:00:00

abstract：:Acetaminophen (APAP) is the leading worldwide cause of drug overdose and acute liver failure (ALF). Single overdose ingestion and therapeutic misadventure may cause hepatotoxicity. Several factors, such as concomitant alcohol use or abuse, concurrent medications, genetic factors, and nutritional status, can influence ...

journal_title：Clinics in liver disease

authors： Bunchorntavakul C,Reddy KR

更新日期：2013-11-01 00:00:00

abstract：:With obesity reaching epidemic proportions in the United States, it is imperative that hepatologists have an understanding of the medical ramifications and methods of treatment. Evaluation of nonalcoholic fatty liver disease may get the patient into the office,but weight reduction may provide a therapeutic hurdle. Thi...

journal_title：Clinics in liver disease

authors： Bouneva I,Kirby DF

更新日期：2004-08-01 00:00:00

abstract：:The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes. Covert hepatic encephalopathy, which is defined as abnormal performance on psychometric tests when standard neurologic examination is completely normal, has gained widespre...

journal_title：Clinics in liver disease

authors： Edula RG,Pyrsopoulos NT

更新日期：2015-08-01 00:00:00

abstract：:Liver cancer is the second leading cause of global cancer mortality. The major risk factors for hepatocellular carcinoma (HCC) are being addressed with success by prevention efforts. Vaccination against hepatitis B virus has reduced incidence of HCC in Taiwan and is partly responsible for lower rates in China. New inf...

journal_title：Clinics in liver disease

authors： McGlynn KA,Petrick JL,London WT

更新日期：2015-05-01 00:00:00

abstract：:Despite significant advances in nonsurgical treatments of hepatocellular carcinoma, these approaches rarely result in cure. Surgery remains the mainstay of curative therapy for hepatocellular carcinoma. Liver transplantation, in particular, has emerged as one of the most beneficial therapeutic modalities. Questions re...

journal_title：Clinics in liver disease

authors： Masuoka HC,Rosen CB

更新日期：2011-05-01 00:00:00

abstract：:Decision analysis helps evaluate competing strategies under conditions of uncertainty in a wide variety of clinical settings. Despite some limitations, decision trees and Markov models remain essential tools for medical decision analysts. These techniques allow comparison of competing management strategies in a quanti...

journal_title：Clinics in liver disease

authors： Kim WR

更新日期：2005-05-01 00:00:00

abstract：:Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obs...

journal_title：Clinics in liver disease

authors： Chapin CA,Bass LM

更新日期：2018-11-01 00:00:00

abstract：:The diagnosis of AIH depends on the finding of several suggestive features together with careful exclusion of liver diseases of other etiologies. Wherever possible, the diagnosis should be confirmed histologically by an experienced hepatopathologist. Seronegativity for the conventional autoantibodies at presentation d...

journal_title：Clinics in liver disease

authors： McFarlane IG

更新日期：2002-08-01 00:00:00

abstract：:Standard therapy with pegylated interferon and ribavirin for chronic hepatitis C is effective in 40% to 50% of individuals with genotype 1 hepatitis C virus (HCV) infection and is associated with significant treatment-related toxicities. Newly developed small molecules that target key enzymes essential for HCV replica...

journal_title：Clinics in liver disease

authors： Weisberg IS,Jacobson IM

更新日期：2009-08-01 00:00:00

abstract：:Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

journal_title：Clinics in liver disease

authors： Bonder A,Tapper EB,Afdhal NH

更新日期：2015-02-01 00:00:00

abstract：:Osteopenia, in the form of osteoporosis, is a common complication of chronic cholestatic liver diseases and, although its cause is poorly understood, it appears to be intimately related to the cholestasis itself. With more patients surviving longer with successful liver transplantation, the clinical significance of su...

journal_title：Clinics in liver disease

authors： Hay JE

更新日期：1998-05-01 00:00:00

abstract：:The management of patients who have portal hypertension has changed dramatically over the last 2 decades. Pharmacologic therapy benefits the patient by reducing the risk for an initial bleed, improving the management of an acute bleed, and in reducing the risk for a rebleed. Endoscopic management has improved progress...

journal_title：Clinics in liver disease

authors： Henderson JM

更新日期：2006-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a systemic disease with hepatic and extrahepatic manifestations, including neuropsychiatric conditions. Depression is a frequent disorder, which has been reported in one-third of patients with HCV infection and has an estimated prevalence of 1.5 to 4.0 times higher than that observ...

journal_title：Clinics in liver disease

authors： Adinolfi LE,Nevola R,Rinaldi L,Romano C,Giordano M

更新日期：2017-08-01 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is the most common indication for liver transplantation in the United States and Europe, and more than 20,000 patients worldwide have undergone transplantation for complications of chronic hepatitis C. In North America, HCV accounts for 15% to 50% of the liver transplants perf...

journal_title：Clinics in liver disease

authors： Biggins SW,Terrault NA

更新日期：2005-08-01 00:00:00

abstract：:Primary biliary cirrhosis is an insidious disease that progresses through the clinical phases: preclinical, asymptomatic, symptomatic, and liver insufficiency. The outlook of patients diagnosed with PBC has improved significantly over the past 2 decades because more patients are being diagnosed earlier in the disease ...

journal_title：Clinics in liver disease

authors： Mayo MJ

更新日期：2008-05-01 00:00:00

abstract：:Although hepatic encephalopathy (HE) is prevalent in the cirrhotic population, it has also been considered a potentially reversible condition. Liver transplantation represents the ultimate reversal of the decompensated cirrhotic state and should provide the best option for the reversibility of HE. However, the neurolo...

journal_title：Clinics in liver disease

authors： Frederick RT

更新日期：2012-02-01 00:00:00

abstract：:Good management of patients at risk for the development of hepatocellular carcinoma includes regular ultrasound surveillance, and aggressive management of lesions detected at ultrasound. Good radiology and good pathology are essential to the appropriate management of these small lesions. With good quality testing it i...

journal_title：Clinics in liver disease

authors： Sherman M

更新日期：2007-11-01 00:00:00

abstract：:Pruritus is a common symptom with primary biliary cholangitis. Research has focused on refining understanding of the neurohumoral pathways involved in transduction of pruritus from peripheral cutaneous receptors to the central nervous system, and identifying modulating drugs. Current treatments have variable efficacy ...

journal_title：Clinics in liver disease

authors： Carrion AF,Rosen JD,Levy C

更新日期：2018-08-01 00:00:00

abstract：:Liver transplant (LT) is now an established indication for patients with chronic hepatitis B, mainly because of the development and use of hepatitis B immunoglobulin (HBIG) and oral antivirals for prophylaxis. The combination of low-dose HBIG and antivirals has been considered the standard prophylaxis regimen to preve...

journal_title：Clinics in liver disease

authors： Saab S,Chen PY,Saab CE,Tong MJ

更新日期：2016-11-01 00:00:00

abstract：:Viral hepatitis can cause a wide spectrum of clinical presentations from a benign form with minimal or no symptoms to acute liver failure or death. Hepatitis D coinfection and superinfection have distinct clinical courses, with the latter more likely leading to chronic infection. Management of chronic hepatitis D viru...

journal_title：Clinics in liver disease

authors： Cheung A,Kwo P

更新日期：2020-08-01 00:00:00

abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure used in the management of complications of portal hypertension. Although the most robust evidence supports the use of TIPS as salvage therapy in variceal hemorrhage, secondary prophylaxis of variceal bleeding, and treatment of refract...

journal_title：Clinics in liver disease

authors： Hung ML,Lee EW

更新日期：2019-11-01 00:00:00

abstract：:The study of hepatitis C virus (HCV) molecular virology is helping to shape the future of our anti-HCV strategies by identifying new antiviral targets. With the advent of agents that specifically target individual HCV proteins, HCV-specific therapy has arrived. Key to these efforts is the development of high-efficienc...

journal_title：Clinics in liver disease

authors： Glenn JS

更新日期：2005-08-01 00:00:00

abstract：:Although recent evidence indicates that the quasispecies nature of HCV constitutes a critical strategy for the virus to survive in the host, the mechanisms of viral persistence remain unknown. Similarly, the correlates of immune protection in a limited proportion of individuals who succeed in clearing HCV are still la...

journal_title：Clinics in liver disease

authors： Farci P

更新日期：2001-11-01 00:00:00

abstract：:Abnormalities of LFTs and liver function occur not infrequently in patients with rheumatic conditions, and many diagnostic possibilities exist. Systemic inflammation that is related to uncontrolled rheumatic disease and periods of disease remission have been described as a cause for fluctuations in levels of serum ami...

journal_title：Clinics in liver disease

authors： Walker NJ,Zurier RB

更新日期：2002-11-01 00:00:00

abstract：:For patients who present with variceal bleeding refractory to endoscopic and pharmacologic methods, TIPS is a new and effective therapy. Stents are used in selected patients with decompensated liver disease and those who anticipate liver transplantation within 6 to 12 months. Surveillance of TIPS with ultrasound, with...

journal_title：Clinics in liver disease

authors： Faust TW,Sorrell MF

更新日期：1997-05-01 00:00:00

abstract：:In conclusion, the natural history of chronic HCV infection has not yet been fully defined. Current data suggest that the process runs an indolent course during the first two decades after initial infection, accounting for modest morbidity and mortality. Serious sequelae are more likely to emerge as the disease proces...

journal_title：Clinics in liver disease

authors： Seeff LB

更新日期：1997-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is recognized as a global health problem and as a common cause of chronic liver disease. Nonalcoholic steatohepatitis (NASH) carries an increased risk for development of advanced liver disease. Lifestyle modifications with diet and exercise have been the initial management reco...

journal_title：Clinics in liver disease

authors： Golabi P,Bush H,Younossi ZM

更新日期：2017-11-01 00:00:00