Cirrhosis and Portal Hypertension in the Pediatric Population.

abstract：:For patients who present with variceal bleeding refractory to endoscopic and pharmacologic methods, TIPS is a new and effective therapy. Stents are used in selected patients with decompensated liver disease and those who anticipate liver transplantation within 6 to 12 months. Surveillance of TIPS with ultrasound, with...

journal_title：Clinics in liver disease

authors： Faust TW,Sorrell MF

更新日期：1997-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the liver disease associated with obesity, diabetes, and the metabolic syndrome. Although steatosis is a key histologic feature, liver biopsies of patients with NAFLD can show a wide range of findings. Nonalcoholic steatohepatitis (NASH) is a progressive subtype of NAFLD fir...

journal_title：Clinics in liver disease

authors： Kleiner DE,Makhlouf HR

更新日期：2016-05-01 00:00:00

abstract：:Liver dysfunction is common in both the critically ill and postoperative patient. Metabolic derangements secondary to sepsis, poor hepatic perfusion, total parenteral nutrition, in addition to hemodynamic and anesthetic-induced changes that occur during surgery, can cause liver damage ranging from small self-limited a...

journal_title：Clinics in liver disease

authors： Aronsohn A,Jensen D

更新日期：2011-02-01 00:00:00

abstract：:Newer noninvasive tests have begun to replace liver biopsy for staging purposes. The clinician must evaluate these tools and apply them to individual patients. None of these modalities give the exact same staging of fibrosis as a liver biopsy, but they are excellent tools for risk stratification. Still, it should be r...

journal_title：Clinics in liver disease

authors： Bonder A,Tapper EB,Afdhal NH

更新日期：2015-02-01 00:00:00

abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) is a well-established procedure used in the management of complications of portal hypertension. Although the most robust evidence supports the use of TIPS as salvage therapy in variceal hemorrhage, secondary prophylaxis of variceal bleeding, and treatment of refract...

journal_title：Clinics in liver disease

authors： Hung ML,Lee EW

更新日期：2019-11-01 00:00:00

abstract：:Scientists and clinicians have made tremendous advances in understanding the pathogenesis of hepatitis C virus (HCV) infection and have developed impressive strategies for treating this hepatotropic virus in the short time since its discovery in 1989. This article goes beyond the current guidelines for the treatment o...

journal_title：Clinics in liver disease

authors： Darling JM,Fried MW

更新日期：2006-11-01 00:00:00

abstract：:In summary, re-OLT accounts for 10% of all OLTs performed and is associated with significantly increased resource use, and decreased survival compared with primary OLT. After transplantation into an HCV-infected recipient, infection of the allograft by HCV is invariable. As patients survive longer after liver transpla...

journal_title：Clinics in liver disease

authors： Forman LM

更新日期：2003-08-01 00:00:00

abstract：:Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discuss...

journal_title：Clinics in liver disease

authors： Habib A,Desai K,Hickey R,Thornburg B,Lewandowski R,Salem R

更新日期：2015-05-01 00:00:00

abstract：:The diagnosis of hepatic encephalopathy is predominantly clinical, and the tests available assist in the diagnosis only by excluding other causes. Covert hepatic encephalopathy, which is defined as abnormal performance on psychometric tests when standard neurologic examination is completely normal, has gained widespre...

journal_title：Clinics in liver disease

authors： Edula RG,Pyrsopoulos NT

更新日期：2015-08-01 00:00:00

abstract：:Nonalcoholic fatty liver (NAFL) is increasingly recognized as an important and common public health problem that can lead to cirrhosis and hepatic failure. Because it is often asymptomatic,many people may not know that they have it. NAFL is closely linked to obesity, which in the United States and other developed coun...

journal_title：Clinics in liver disease

authors： Ruhl CE,Everhart JE

更新日期：2004-08-01 00:00:00

abstract：:Since publication of the first descriptions of acute liver failure (ALF) as a distinct clinical entity in the 1950's, the understanding of the pathophysiologic mechanisms involved and the management options have increased substantially. ALF still represents a major challenge for todays hepatologists, because it can ra...

journal_title：Clinics in liver disease

authors： Khan SA,Shah N,Williams R,Jalan R

更新日期：2006-05-01 00:00:00

abstract：:Hepatobiliary dysfunction associated with the use of total parenteral nutrition is a commonly recognized phenomenon occurring in up to 90% of patients on long-term therapy. Reasons for these abnormalities, both supported by research as well as theoretical possibilities are explored. Practical guidelines considered use...

journal_title：Clinics in liver disease

authors： Porayko MK

更新日期：1998-02-01 00:00:00

abstract：:Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to exte...

journal_title：Clinics in liver disease

authors： Chatterjee A,Smith PF,Perelson AS

更新日期：2013-02-01 00:00:00

abstract：:Histologic cholestasis and clinical jaundice may be seen in all stages of alcoholic liver disease. In rare cases, isolated cholestasis without significant steatosis, hepatitis, or cirrhosis is identified in an alcoholic patient. The mechanisms of ethanol-induced cholestasis are not well studied but may involve compres...

journal_title：Clinics in liver disease

authors： Tung BY,Carithers RL Jr

更新日期：1999-08-01 00:00:00

abstract：:The risk for potential transmission of infectious agents during gastrointestinal (GI) endoscopy is concerning for patients and physicians. However, the instance of infection transmission remains rare after GI endoscopy procedures, with an estimated frequency of 1 in 1.8 million procedures. Endoscopy-related infection ...

journal_title：Clinics in liver disease

authors： Wu H,Shen B

更新日期：2010-02-01 00:00:00

abstract：:Although several mouse models of AIH have been described, no model is ideal. Indeed, the disease is self-limited in each model, and none is associated with significant liver fibrosis or progression to cirrhosis. Nevertheless, these models should be useful for testing different hypotheses regarding the initiation of AI...

journal_title：Clinics in liver disease

authors： Howell CD

更新日期：2002-08-01 00:00:00

abstract：:Steatosis is a common finding in patients with chronic hepatitis C (CHC) due to a combination of the direct steatogenic effect of hepatitis C virus (HCV) and the prevalence of metabolic risk factors in the HCV population. Steatosis is now established as a risk factor for disease progression in CHC and significantly im...

journal_title：Clinics in liver disease

authors： Dev A,Patel K,McHutchison JG

更新日期：2004-11-01 00:00:00

abstract：:The incidence of newly acquired hepatitis C infection has diminished in the United States. This decline is largely because of a decrease in cases among IDUs for reasons that are unclear and, to a lesser extent, to testing of blood donors for HCV. The virus is transmitted by blood, and such transmission now occurs prim...

journal_title：Clinics in liver disease

authors： Seeff LB,Hoofnagle JH

更新日期：2003-02-01 00:00:00

abstract：:Both covert hepatic encephalopathy (CHE) and overt hepatic encephalopathy (OHE) impair the ability to operate machinery. The legal responsibilities of US physicians who diagnose and treat patients with hepatic encephalopathy vary among states. It is imperative that physicians know the laws regarding reporting in their...

journal_title：Clinics in liver disease

authors： Vierling JM

更新日期：2015-08-01 00:00:00

abstract：:Serologic assays for HBV are the mainstay diagnostic tools for HBV infection. However, the advent of molecular biology-based techniques has added a new dimension to the diagnosis and treatment of patients with chronic HBV infection. Over the past decade, improvements in molecular technology, permitting detection of as...

journal_title：Clinics in liver disease

authors： Servoss JC,Friedman LS

更新日期：2004-05-01 00:00:00

abstract：:Liver transplant (LT) is now an established indication for patients with chronic hepatitis B, mainly because of the development and use of hepatitis B immunoglobulin (HBIG) and oral antivirals for prophylaxis. The combination of low-dose HBIG and antivirals has been considered the standard prophylaxis regimen to preve...

journal_title：Clinics in liver disease

authors： Saab S,Chen PY,Saab CE,Tong MJ

更新日期：2016-11-01 00:00:00

abstract：:Imaging and imaging guided intervention have revolutionized the management of hepatic inflammatory diseases. Pyogenic abscess is preferentially treated percutaneously. Radiologic techniques are crucial for the diagnosis of amebic liver abscess and infectious conditions of the liver in immunocompromised patients. ...

journal_title：Clinics in liver disease

authors： Ralls PW

更新日期：2002-02-01 00:00:00

abstract：:The incidence of nonalcoholic fatty liver disease is increasing at an astonishing rate in the US population. Although only a small proportion of these patients develop steatohepatitis (NASH), those who do have a greater likelihood of developing end-stage liver disease and complications. Research on liver fibrosis and ...

journal_title：Clinics in liver disease

authors： Bohinc BN,Diehl AM

更新日期：2012-08-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterized by the presence of high-titer disease specific autoantibodies directed against mitochondrial antigens (AMA) of the inner mitochondrial membrane, that are members of the 2-oxo acid complex. Among numerous other autoantibodies found in PBC the focus of ongoing studies is ...

journal_title：Clinics in liver disease

authors： Bogdanos DP,Baum H,Vergani D

更新日期：2003-11-01 00:00:00

abstract：:Good management of patients at risk for the development of hepatocellular carcinoma includes regular ultrasound surveillance, and aggressive management of lesions detected at ultrasound. Good radiology and good pathology are essential to the appropriate management of these small lesions. With good quality testing it i...

journal_title：Clinics in liver disease

authors： Sherman M

更新日期：2007-11-01 00:00:00

abstract：:Obesity has become increasingly prevalent, and the number of obese patients in need of liver transplant is expected to continue to increase. In addition, liver disease due to nonalcoholic fatty liver disease is expected to become the leading cause of liver transplantation in the near future. However, obesity remains a...

journal_title：Clinics in liver disease

authors： Suraweera D,Dutson E,Saab S

更新日期：2017-05-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are examples of complex diseases accompanied by changes in the expression of thousands of genes and a plethora of proteins encoded by these genes. Before the era of high-throughput analysis, typical translational research initiatives, a...

journal_title：Clinics in liver disease

authors： Baranova A,Liotta L,Petricoin E,Younossi ZM

更新日期：2007-02-01 00:00:00

abstract：:A human betaretrovirus has been characterized in patients with primary biliary cirrhosis (PBC) and the related mouse mammary tumor virus linked with autoimmune biliary disease in the NOD.c3c4 mouse model. Translational studies have been performed in patients who have PBC to investigate the role of viral infection in d...

journal_title：Clinics in liver disease

authors： Mason AL,Wasilenko ST

更新日期：2008-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a common liver disorder that can be divided into benign steatosis or nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Elastography and scoring systems based on clinical features and routine biochemical testing can be used to assess fibrosis in patient...

journal_title：Clinics in liver disease

authors： Gunn NT,Shiffman ML

更新日期：2018-02-01 00:00:00

abstract：:Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular car...

journal_title：Clinics in liver disease

authors： Abdelaal R,Yanny B,El Kabany M

更新日期：2019-08-01 00:00:00