Pathogenesis of hepatocellular carcinoma.

Abstract:

:The pathogenesis of HCC is poorly understood at present. There is insufficient understanding to propose a robust general model of hepatic carcinogenesis, partly because pathogenic host and environmental factors show significant regional variation, making such generalization difficult. Figure 4 is a model based on data presented in this article. Multiple risk factors for HCC have been identified, including cirrhosis, male gender, increasing patient age, toxins, chronic viral hepatitis, and other specific liver diseases. The understanding of how the individual risk factors result in genetic changes is rudimentary, and there is even less understanding about interactions between risk factors. Future studies should acknowledge the geographic origin of the HCCs studied and consider the effects of cirrhosis, gender, and age. A more rigorous approach to these factors may help explicate the interaction with specific liver diseases so that a comprehensive model of hepatic carcinogenesis can be developed.

journal_name

Clin Liver Dis

journal_title

Clinics in liver disease

authors

Macdonald GA

doi

10.1016/s1089-3261(05)70154-9

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

69-85

issue

1

eissn

1089-3261

issn

1557-8224

pii

S1089-3261(05)70154-9

journal_volume

5

pub_type

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