Surgical bypass versus endoscopic stenting for malignant gastroduodenal obstruction: a decision analysis.


:The treatment options for palliating malignant gastroduodenal obstruction include open gastrojejunostomy (OGJ), laparoscopic gastrojejunostomy (LGJ), and endoscopic stenting (ES). The aim of this study was to compare the clinical outcomes and costs among ES, OGJ, and LGJ in patients who present with gastroduodenal obstruction from advanced upper gastrointestinal tract cancer. We designed a model for patients with malignant gastroduodenal obstruction. We analyzed success rates, complication rates and costs of the three treatment modalities: ES, OGJ, and LGJ. Baseline outcomes and costs were based on published reports. Success was defined as no major procedure-related and long-term complications over a 1-month period. Failure of therapy was defined as recurrent symptoms or death due to a procedural complication. Sensitivity analyses and cost-effectiveness analyses for the various strategies were performed. ES resulted in the lowest mortality rate and the lowest cost of the three treatment options analyzed. Mortality in the OGJ group was 2.1 times that in the ES cohort and 1.8 times that in the LGJ cohort. Sensitivity analyses confirmed ES as the dominant strategy. In conclusion, ES is the preferred treatment for palliation of duodenal obstruction due to advanced upper gastrointestinal tract cancer.


Dig Dis Sci


Siddiqui A,Spechler SJ,Huerta S




Has Abstract


2007-01-01 00:00:00












  • Sulfamethoxazole-induced hepatic injury.

    abstract::A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described. In contrast to the histologic picture of hepatocellular necrosis with or without cholestasis that is generally associated with sulfonamide hepatotoxicity, in the present case a relatively pure cholestatic pattern was fou...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Steinbrecher UP,Mishkin S

    更新日期:1981-08-01 00:00:00

  • Specific metabolic effect of sodium nitrite on fat metabolism by mucosal cells of the colon.

    abstract::The effect on the mucosa of sodium nitrite that enters the colon from the ileum or transmucosally from the circulation is unknown. Isolated colonic mucosal cells and Roux-en-Y colostomies were used to test whether high doses of sodium nitrite (5-40 mM) had any harmful histological or inhibitory metabolic actions on th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Roediger WE,Radcliffe BC,Deakin EJ,Nance SH

    更新日期:1986-05-01 00:00:00

  • Image Analysis of Eosinophil Peroxidase Immunohistochemistry for Diagnosis of Eosinophilic Esophagitis.

    abstract:BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires manual quantification of tissue eosinophils. Eosinophil peroxidase (EPX) is an eosinophil-specific, cytoplasmic granule protein released during degranulation. AIMS:The objective of this study was to evaluate image analysis of EPX immunohistochemistry as a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wright BL,Doyle AD,Shim KP,Pai RK,Barshow SM,Horsley-Silva JL,Luo H,Rank MA,Jacobsen EA,Katzka DA,Kita H,Dellon ES

    更新日期:2020-04-04 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Ha NB,Ha NB,Chaung KT,Trinh HN,Nguyen HA,Nguyen KK,Nguyen MH

    更新日期:2014-01-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Sharaiha RZ,Freedberg DE,Abrams JA,Wang YC

    更新日期:2014-06-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Delpre G,Mor C,Avidor I,Gutman H,Leisser A,Kott I,Kadish U

    更新日期:1989-02-01 00:00:00

  • Magnesium transport across colon ascendens of the rat.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Karbach U

    更新日期:1989-12-01 00:00:00

  • Impaired alveolar gas exchange in acute pancreatitis.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Salomone T,Tosi P,Di Battista N,Binetti N,Raiti C,Tomassetti P,Migliori M,Gullo L

    更新日期:2002-09-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Pulimood AB,Mathan MM,Mathan VI

    更新日期:1998-09-01 00:00:00

  • [*C]octanoic acid breath test to measure gastric emptying rate of solids.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Maes BD,Ghoos YF,Rutgeerts PJ,Hiele MI,Geypens B,Vantrappen G

    更新日期:1994-12-01 00:00:00

  • Mechanisms of Probiotic VSL#3 in a Rat Model of Visceral Hypersensitivity Involves the Mast Cell-PAR2-TRPV1 Pathway.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Li YJ,Dai C,Jiang M

    更新日期:2019-05-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wang JC,Castell DO,Sinclair JW,Wu WC

    更新日期:1989-10-01 00:00:00

  • Pharmacokinetics of Infliximab and Reduction of Treatment for Inflammatory Bowel Diseases.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Williet N,Paul S,Peyrin-Biroulet L,Roblin X

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wang Y,Yao WR,Duan JZ,Xu W,Yang GB

    更新日期:2014-10-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Clerici C,Gentili G,Zakko SF,Balò S,Miglietti M,Giansanti M,Modesto R,Guttermuth CF,Morelli A

    更新日期:1997-03-01 00:00:00

  • Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

    abstract::Our aim was to investigate whether there are changes in permeability to sucrose in asymptomatic Helicobacter pylori gastritis. Nineteen asymptomatic subjects with Helicobacter pylori-associated gastritis with no or mild mucosal atrophy and 19 age- and sex-matched normal controls were studied by peroral load of sucrose...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Borch K,Sjöstedt C,Hannestad U,Söderholm JD,Franzén L,Mårdh S

    更新日期:1998-04-01 00:00:00

  • Acute myeloblastic leukemia following prolonged treatment of Crohn's disease with 6-mercaptopurine.

    abstract::A 65-year-old man with Crohn's disease died of acute myeloblastic leukemia after treatment for 11.8 years with 6-mercaptopurine, 1.5 mg/kg/day (100 mg/day). On cytogenetic analysis, most of the malignant bone marrow cells had deletion of chromosome 7, the most frequently reported cytogenetic abnormality in chemotherap...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Heizer WD,Peterson JL

    更新日期:1998-08-01 00:00:00

  • Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon.

    abstract::It is known that the muscularis mucosae and mucosa are not pharmacologically homogeneous throughout the rat colon. The aim of this study was to simultaneously characterize all three neurokinin (NK) receptors in the muscularis mucosae and mucosa along the length of the rat colon. Strips of proximal, mid, and distal col...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Appleyard CB,Morales M,Percy WH

    更新日期:2006-03-01 00:00:00

  • Medium- and high-dose omeprazole plus amoxicillin for eradication of Helicobacter pylori in duodenal ulcer disease.

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Labenz J,Rühl GH,Bertrams J,Börsch G

    更新日期:1994-07-01 00:00:00

  • The Use of Temporary Fecal Diversion in Colonic and Perianal Crohn's Disease Does Not Improve Outcomes.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bafford AC,Latushko A,Hansraj N,Jambaulikar G,Ghazi LJ

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  • Suprahepatic vein oxygen tension in alcoholics with severe and mild liver damage.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bunout D,Moya P,de la Maza MP,Petermann M,Iturriaga H,Hirsch S

    更新日期:1995-06-01 00:00:00

  • Cyclooxygenase-2 promotes hepatocellular apoptosis by interacting with TNF-α and IL-6 in the pathogenesis of nonalcoholic steatohepatitis in rats.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cheng Q,Li N,Chen M,Zheng J,Qian Z,Wang X,Huang C,Xu S,Shi G

    更新日期:2013-10-01 00:00:00

  • Measurement of small intestinal permeability markers, lactulose, and mannitol in serum: results in celiac disease.

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cox MA,Lewis KO,Cooper BT

    更新日期:1999-02-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Llamas MA,Aller MA,Marquina D,Nava MP,Arias J

    更新日期:2010-08-01 00:00:00

  • Functional Gastrointestinal Symptoms Are Associated with Higher Serum Total IgE Levels, but Less Atopic Sensitization.

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    pub_type: 杂志文章


    authors: Vara EJ,Svanes C,Skorge TD,Berstad A,Florvaag E,Jarvis D,Omenaas E,Waatevik M,Johannessen A,Lied GA

    更新日期:2016-01-01 00:00:00

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    pub_type: 杂志文章,评审


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    更新日期:2005-12-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Hui WM,Lam SK,Chau PY,Ho J,Lui I,Lai CL,Lok AS,Ng MM

    更新日期:1987-11-01 00:00:00

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Yue W,Liu Y,Jiang W,Huang J,Liu J

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    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Morita T,Tamura S,Yokoyama Y,Onishi T,Kuratani Y,Mizuta H,Onishi S

    更新日期:2007-06-01 00:00:00