当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Progressive mRNA decay establishes an mkp3 expression gradient in the chick limb bud.

Progressive mRNA decay establishes an mkp3 expression gradient in the chick limb bud.

Abstract：

:The apical ectodermal ridge (AER) controls limb outgrowth and patterning, such that its removal causes changes in mesodermal gene expression, cell death and limb truncation. Fibroblast growth factor (FGF) family members are expressed in the AER and can rescue limb bud outgrowth after AER removal. Cells localized underneath the AER are maintained in an undifferentiated state by the FGFs produced by the AER. MAPK phosphatase 3 (mkp3) is a downstream effector of FGF8 signalling during limb bud development and is expressed in the distal limb mesenchyme. The present work evidences a gradient of mkp3 transcripts along the chick limb bud, in a distal to proximal direction. mkp3 transcription occurs only in the most distal limb bud cells and its mRNA gradient throughout the limb results from progressive mRNA decay. We show that FGF8-soaked beads induce ectopic mkp3 expression, indicating that AER-derived FGF8 protein may activate mkp3 in the distal mesenchyme.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pascoal S,Andrade RP,Bajanca F,Palmeirim I

doi

10.1016/j.bbrc.2006.10.186

subject

Has Abstract

pub_date

2007-01-05 00:00:00

pages

153-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02437-5

journal_volume

352

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • A minimized Fc binding peptide from protein A induces immunocyte proliferation and evokes Th1-type response in mice.

    abstract：:It is now well established that PA is a potent biological response modifier, showing simultaneously antitumor, antitoxic, anticarcinogenic, antifungal, antiparasitic and immunomodulatory properties. Since PA is a foreign protein, it is quite logical to assume that it may be cleaved into smaller peptide fragments in vi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0363

    authors： Sinha P,Sengupta J,Ray PK

    更新日期：1999-04-29 00:00:00

  • High resolution physical mapping and identification of transcribed sequences in the Down syndrome region-2.

    abstract：:The identification and mapping of genes within the Down syndrome region is an important step toward a complete understanding of the pathogenesis of this disorder. The objective of the present work is to identify and map genes within the Down syndrome region-2. Chromosome 21 cosmid clones corresponding to "cosmid pocke...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8141

    authors： Vidal-Taboada JM,Bergoñón S,Sánchez M,López-Acedo C,Groet J,Nizetic D,Egeo A,Scartezzini P,Katsanis N,Fisher EM,Delabar JM,Oliva R

    更新日期：1998-02-13 00:00:00

  • The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.

    abstract：:Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-s...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80134-1

    authors： Beckman BS,Mason-Garcia M,Nystuen L,King L,Fisher JW

    更新日期：1987-08-31 00:00:00

  • Apolipoprotein E-knockout mice show increased titers of serum anti-nuclear and anti-dsDNA antibodies.

    abstract：:Apolipoprotein E-knockout (ApoE(-/-)) mice, atherosclerosis-prone mice, show an autoimmune response, but the pathogenesis is not fully understood. We investigated the pathogenesis in female and male ApoE(-/-) mice. The spleens of all ApoE(-/-) and C57BL/6 (B6) mice were weighed. The serum IgG level and titers of anti-...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.06.044

    authors： Wang Y,Huang Z,Lu H,Lin H,Wang Z,Chen X,Ouyang Q,Tang M,Hao P,Ni J,Xu D,Zhang M,Zhang Q,Lin L,Zhang Y

    更新日期：2012-07-13 00:00:00

  • Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines.

    abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic compound affecting the expression of inflammatory genes. We found that TCDD induces the expression of the B-cell activating factor of the tumor necrosis factor family (BAFF), B-lymphocyte chemoattractant (BLC), CC-chemokine ligand 1 (CCL1), and the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.032

    authors： Vogel CF,Sciullo E,Matsumura F

    更新日期：2007-11-23 00:00:00

  • Overexpression of a phosphate transporter gene ZmPt9 from maize influences growth of transgenic Arabidopsis thaliana.

    abstract：:Phosphate transporters (PHTs) are well-known for their roles in phosphate uptake in plants. However, their actions in imparting plant growth in plants are still not so clear. In our previous study, we observed that maize PHT1 gene ZmPt9 plays a significant role in phosphate uptake. In this study, we further characteri...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.09.039

    authors： Xu Y,Bao H,Fei H,Zhou W,Li X,Liu F

    更新日期：2020-09-19 00:00:00

  • Differential regulation of splicing, localization and stability of mammalian ARD1235 and ARD1225 isoforms.

    abstract：:ARD1 protein is a mammalian gene product homologous to a yeast Ard1p (Arrest defective 1 protein) acetyltransferase. Although two alternative splicing products of ARD1, ARD1(235) and ARD1(225), were reported in mouse, only ARD1(235) orthologue was reported in humans. Here we show that ARD1(225) is not expressed in hum...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.131

    authors： Chun KH,Cho SJ,Choi JS,Kim SH,Kim KW,Lee SK

    更新日期：2007-02-02 00:00:00

  • Cloning and sequencing of human FSH receptor cDNA.

    abstract：:We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain wh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(91)91682-3

    authors： Minegishi T,Nakamura K,Takakura Y,Ibuki Y,Igarashi M,Minegish T corrected to Minegishi T

    更新日期：1991-03-29 00:00:00

  • Identification of an essential lysine residue in the beta subunit of the F1-ATPase from the thermophilic bacterium, PS3, using 7-chloro-4-nitro[14C]benzofurazan.

    abstract：:When the F1-ATPase from the thermophilic bacterium, PS3, was inactivated by 90% with 7-chloro-4-nitro[14C]benzofurazan ([14C]Nbf-Cl) at pH 7.3 and then gel-filtered, 1.25 mols of [14C]Nbf-O-Tyr and less than 0.1 mol of Nbf-N-Lys were formed per mol of enzyme. After adjusting the pH of the gel-filtered, modified enzyme...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80238-7

    authors： Andrews WW,Yoshida M,Hill FC,Allison WS

    更新日期：1984-09-28 00:00:00

  • Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration.

    abstract：:Tumor necrosis factor alpha (TNFalpha) is a pleiotropic cytokine involved in apoptotic cell death, cellular proliferation, differentiation, inflammation, and tumorigenesis. In tumors it is secreted by tumor associated macrophages and can have both pro- and anti-tumorigenic effects. To identify genes regulated by TNFal...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.070

    authors： Guardiola-Serrano F,Haendeler J,Lukosz M,Sturm K,Melchner Hv,Altschmied J

    更新日期：2008-11-28 00:00:00

  • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

    abstract：:Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.07.147

    authors： Muñoz JP,Collao A,Chiong M,Maldonado C,Adasme T,Carrasco L,Ocaranza P,Bravo R,Gonzalez L,Díaz-Araya G,Hidalgo C,Lavandero S

    更新日期：2009-10-09 00:00:00

  • CircPRKCI-miR-545/589-E2F7 axis dysregulation mediates hydrogen peroxide-induced neuronal cell injury.

    abstract：:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.04.131

    authors： Cheng Q,Cao X,Xue L,Xia L,Xu Y

    更新日期：2019-06-25 00:00:00

  • The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.

    abstract：:Gastric inhibitory polypeptide (GIP) is released from the small intestine upon meal ingestion and increases insulin secretion from pancreatic β cells. Although the GIP receptor is known to be expressed in small intestine, the effects of GIP in small intestine are not fully understood. This study was designed to clarif...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.11.077

    authors： Ogawa E,Hosokawa M,Harada N,Yamane S,Hamasaki A,Toyoda K,Fujimoto S,Fujita Y,Fukuda K,Tsukiyama K,Yamada Y,Seino Y,Inagaki N

    更新日期：2011-01-07 00:00:00

  • Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model.

    abstract：:Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.05.001

    authors： Kaylani SZ,Xu J,Srivastava RK,Kopelovich L,Pressey JG,Athar M

    更新日期：2013-06-14 00:00:00

  • Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.

    abstract：:PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was as...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.063

    authors： Kwon OH,Kang TW,Kim JH,Kim M,Noh SM,Song KS,Yoo HS,Kim WH,Xie Z,Pocalyko D,Kim SY,Kim YS

    更新日期：2012-06-22 00:00:00

  • Long non-coding RNA CASP5 promotes the malignant phenotypes of human glioblastoma multiforme.

    abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) have been demonstrated to be intensively involved in the development of various carcinomas, including glioblastoma multiforme (GBM). However, only a few of them have been well characterized. LncRNA CASP5 have been found to be up-regulated in GBM tissues compared with normal tis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.04.217

    authors： Zhou Y,Dai W,Wang H,Pan H,Wang Q

    更新日期：2018-06-12 00:00:00

  • Androgen receptor is up-regulated by a BLT2-linked pathway to contribute to prostate cancer progression.

    abstract：:The androgen receptor (AR) plays a central role in the development and progression of prostate cancer. AR expression is maintained throughout the progression of prostate cancer and is also associated with an aggressive, castration-resistant (CR) phenotype. Despite the critical roles of AR expression in prostate cancer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.012

    authors： Lee JW,Kim GY,Kim JH

    更新日期：2012-04-06 00:00:00

  • Effect of peptide acetylation on its interaction with antipeptide antibody.

    abstract：:The effects of trace acetylation on the contact sites in peptide-antibody binding have been investigated by using a label selection method. A 13-residue synthetic peptide having three lysines (LKLVEQQNPKVKL) corresponding to sequence position 155-168 of beta 1,4-galactosyltransferase was used in this study. The four a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2862

    authors： Yadav SP,Rawitch AB

    更新日期：1994-12-30 00:00:00

  • Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions.

    abstract：:Septins, a conserved family of GTPases, are heteropolymeric filament-forming proteins that associate with the cell membrane and cytoskeleton and serve essential functions in cell division and morphogenesis. Their roles in fungal cell wall chitin deposition, septation, cytokinesis, and sporulation have been well establ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.01.017

    authors： Juvvadi PR,Fortwendel JR,Rogg LE,Steinbach WJ

    更新日期：2011-02-11 00:00:00

  • Rosiglitazone enhances the radiosensitivity of p53-mutant HT-29 human colorectal cancer cells.

    abstract：:Combined-modality treatment has improved the outcome in cases of various solid tumors, and radiosensitizers are used to enhance the radiotherapeutic efficiency. Rosiglitazone, a synthetic ligand of peroxisome proliferator-activated receptors gamma used in the treatment of type-2 diabetes, has been shown to reduce tumo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.03.068

    authors： Chiu SJ,Hsaio CH,Tseng HH,Su YH,Shih WL,Lee JW,Chuah JQ

    更新日期：2010-04-09 00:00:00

  • Inter-individual variation of several cytochrome P450 2D6 splice variants in human liver.

    abstract：:To examine the possibility that inter-individual differences in splicing partially explain the observed differences in CYP2D6 activity, we amplified its full-length cDNA in 96 human liver RNA samples and discovered five splice variants: intron 5 retention, intron 6 retention, intron 5 and intron 6 double retention, ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.010

    authors： Denson J,Wu Y,Yang W,Zhang J

    更新日期：2005-05-06 00:00:00

  • Proteomics investigation of endogenous S-nitrosylation in Arabidopsis.

    abstract：:S-Nitrosylation emerges as an important protein modification in many processes. However, most data were obtained at the protein level after addition of a NO donor, particularly in plants where information about the cysteines nitrosylated in these proteins is scarce. An adapted work-flow, combining the classical biotin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.036

    authors： Fares A,Rossignol M,Peltier JB

    更新日期：2011-12-16 00:00:00

  • Evidence that post-transcriptional changes in the expression of mitogen regulated protein accompany immortalization of mouse cells.

    abstract：:Primary mouse embryo fibroblasts passed in culture go through a period of declining growth rate and then after a period of minimal proliferation begin to grow again, generating, under appropriate conditions, an immortal 3T3 line. The 3T3 cells, but not the primary mouse embryo fibroblasts, are able to synthesize and t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80144-4

    authors： Edwards DR,Parfett CL,Smith JH,Denhardt DT

    更新日期：1987-08-31 00:00:00

  • Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease.

    abstract：:SARS-CoV 3CL protease is essential for viral protein processing and is regarded as a good drug target to prevent SARS-CoV replication. In the present study, we established a high-throughput FRET technique for screening for anti-SARS-CoV 3CL protease drugs. Of a thousand existing drugs examined, hexachlorophene was ide...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.05.095

    authors： Liu YC,Huang V,Chao TC,Hsiao CD,Lin A,Chang MF,Chow LP

    更新日期：2005-07-22 00:00:00

  • Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester.

    abstract：:Platelet activating factor has been found to increase the intracellular level of free calcium (as monitored by the fluorescent calcium indicator quin-2) and to stimulate the turnover of the polyphosphoinositides in rabbit neutrophils. Calcium mobilization induced by platelet activating factor, in contrast to previous ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90470-x

    authors： Naccache PH,Molski MM,Volpi M,Becker EL,Sha'afi RI

    更新日期：1985-07-31 00:00:00

  • Ex vivo expansion of hematopoietic stem cell by fusion protein TAT-Zfx.

    abstract：:The relative inability of hemopoietic stem cells (HSCs) to reproduce themselves (self-renew) ex vivo imposes substantial limitations on the current use of HSC transplantation. Recently, the transcription factor Zfx has been demonstrated that played an important in controlling the self-renewal of hematopoietic stem cel...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.bbrc.2008.12.125

    authors： Xu C,Zhang Y,Jiang H

    更新日期：2009-02-13 00:00:00

  • Identification of four genomic loci highly related to casein-kinase-2-alpha cDNA and characterization of a casein kinase-2-alpha pseudogene within the mouse genome.

    abstract：:Using the coding region of the human CK-2 alpha cDNA as a probe for screening a genomic mouse library, positive clones representing four different genomic loci were isolated. Partial DNA sequences of these loci encompassing the first 120 nucleotides of the putative coding region are reported. One positive clone was fu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90806-v

    authors： Boldyreff B,Wehr K,Hecht R,Issinger OG

    更新日期：1992-07-31 00:00:00

  • Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

    abstract：:The receptor for calcitonin gene-related peptide (CGRP) has been the target for the development of novel small molecule antagonists for the treatment of migraine. Two such antagonists, BIBN4096BS and MK-0974, have shown great promise in clinical trials and hence a deeper understanding of the mechanism of their interac...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.11.076

    authors： Miller PS,Barwell J,Poyner DR,Wigglesworth MJ,Garland SL,Donnelly D

    更新日期：2010-01-01 00:00:00

  • Revealing the mode of action of DNA topoisomerase I and its inhibitors by atomic force microscopy.

    abstract：:In this study, we used, for the first time, atomic force microscope (AFM) images to investigate the mode of action of DNA topoisomerase I (topo I) in the presence and absence of its inhibitors: camptothecin (CPT) and tyrphostin AG-1387. The results revealed that in the absence of the inhibitors, the enzyme relaxed sup...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)00025-1

    authors： Argaman M,Bendetz-Nezer S,Matlis S,Segal S,Priel E

    更新日期：2003-02-14 00:00:00

  • Silencing MR-1 attenuates inflammatory damage in mice heart induced by AngII.

    abstract：:Myofibrillogenesis regulator-1(MR-1) can aggravate cardiac hypertrophy induced by angiotensin(Ang) II in mice through activation of NF-kappaB signaling pathway, and nuclear transcription factor (NF)-kappaB and activator protein-1(AP-1) regulate inflammatory and immune responses by increasing the expression of specific...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.12.130

    authors： Dai W,Chen H,Jiang J,Kong W,Wang Y

    更新日期：2010-01-15 00:00:00