Hedgehog signaling and the retina: insights into the mechanisms controlling the proliferative properties of neural precursors.

abstract：:DinI is a recently described negative regulator of the SOS response in Escherichia coli. Here we show that it physically interacts with RecA and prevents the binding of single-stranded DNA to RecA, which is required for the activation of the latter. DinI also displaces ssDNA from a stable RecA-DNA cofilament, thus eli...

journal_title：Genes & development

authors： Voloshin ON,Ramirez BE,Bax A,Camerini-Otero RD

更新日期：2001-02-15 00:00:00

abstract：:Ssn6-Tup1 regulates multiple genes in yeast, providing a paradigm for corepressor functions. Tup1 interacts directly with histones H3 and H4, and mutation of these histones synergistically compromises Ssn6-Tup1-mediated repression. In vitro, Tup1 interacts preferentially with underacetylated isoforms of H3 and H4, sug...

journal_title：Genes & development

authors： Watson AD,Edmondson DG,Bone JR,Mukai Y,Yu Y,Du W,Stillman DJ,Roth SY

更新日期：2000-11-01 00:00:00

abstract：:Dynamic assembly and disassembly of actin filaments is a major driving force for cell movements. Border cells in the Drosophila ovary provide a simple and genetically tractable model to study the mechanisms regulating cell migration. To identify new genes that regulate cell movement in vivo, we screened lethal mutatio...

journal_title：Genes & development

authors： Kim JH,Cho A,Yin H,Schafer DA,Mouneimne G,Simpson KJ,Nguyen KV,Brugge JS,Montell DJ

更新日期：2011-04-01 00:00:00

abstract：:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...

journal_title：Genes & development

authors： Birchler JA,Hiebert JC,Rabinow L

更新日期：1989-01-01 00:00:00

abstract：:During development of the somatic macronucleus of Tetrahymena thermophila, the rDNA is excised from its germ-line chromosome, rearranged into a palindrome, and amplified to 10(4) copies. We have identified a cis-acting germ-line mutation, rmm11/6, that prevents amplification of the rDNA in all but approximately 1 in 1...

journal_title：Genes & development

authors： Kapler GM,Blackburn EH

更新日期：1994-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%-5%. The cancer's lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biol...

journal_title：Genes & development

authors： Hezel AF,Kimmelman AC,Stanger BZ,Bardeesy N,Depinho RA

更新日期：2006-05-15 00:00:00

abstract：:A prominent feature of cell differentiation is the initiation and maintenance of an irreversible cell cycle arrest with the complex involvement of the retinoblastoma (RB) family (RB, p130, p107). We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells. By homo...

journal_title：Genes & development

authors： Tevosian SG,Shih HH,Mendelson KG,Sheppard KA,Paulson KE,Yee AS

更新日期：1997-02-01 00:00:00

abstract：:Gene dosage alterations caused by aneuploidy are a common feature of most cancers yet pose severe proteotoxic challenges. Therefore, cells have evolved various dosage compensation mechanisms to limit the damage caused by the ensuing protein level imbalances. For instance, for heteromeric protein complexes, excess nons...

journal_title：Genes & development

authors： Samant RS,Masto VB,Frydman J

更新日期：2019-08-01 00:00:00

abstract：:Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. Initiation of DNA replication involves the establishment of a prereplication complex (pre-RC) and subsequent activation by CDK/cyclins, converting the pre-RC to a post-RC. The origin recognition complex (ORC), Cdc6p, and...

journal_title：Genes & development

authors： Liang C,Stillman B

更新日期：1997-12-15 00:00:00

abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...

journal_title：Genes & development

authors： Kleiman FE,Wu-Baer F,Fonseca D,Kaneko S,Baer R,Manley JL

更新日期：2005-05-15 00:00:00

abstract：:Discrete sequence elements known as exonic splicing enhancers (ESEs) have been shown to influence both the efficiency of splicing and the profile of mature mRNAs in multicellular eukaryotes. While the existence of ESEs has not been demonstrated previously in unicellular eukaryotes, the factors known to recognize these...

journal_title：Genes & development

authors： Webb CJ,Romfo CM,van Heeckeren WJ,Wise JA

更新日期：2005-01-15 00:00:00

abstract：:When the orphan nuclear receptors TR2 and TR4, the DNA-binding subunits of the DRED repressor complex, are forcibly expressed in erythroid cells of transgenic mice, embryos exhibit a transient mid-gestational anemia as a consequence of a reduction in the number of primitive erythroid cells. GATA-1 mRNA is specifically...

journal_title：Genes & development

authors： Tanabe O,Shen Y,Liu Q,Campbell AD,Kuroha T,Yamamoto M,Engel JD

更新日期：2007-11-01 00:00:00

abstract：:Human ELAV proteins are implicated in cell growth and differentiation via regulation of mRNA expression in the cytoplasm. In human embryonic teratocarcinoma (hNT2) cells transfected with the human neuronal ELAV-like protein, Hel-N1, neurites formed, yet cells were not terminally differentiated. Cells in which neurite ...

journal_title：Genes & development

authors： Antic D,Lu N,Keene JD

更新日期：1999-02-15 00:00:00

abstract：:The contact site A glycoprotein is a developmentally regulated cell-surface component expressed during the aggregation stage of Dictyostelium discoideum. This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells. The gene coding for the contact site A protein w...

journal_title：Genes & development

authors： Harloff C,Gerisch G,Noegel AA

更新日期：1989-12-01 00:00:00

abstract：:Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonuc...

journal_title：Genes & development

authors： D'Ambrosio C,Schmidt CK,Katou Y,Kelly G,Itoh T,Shirahige K,Uhlmann F

更新日期：2008-08-15 00:00:00

abstract：:We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promot...

journal_title：Genes & development

authors： Dorsky RI,Raible DW,Moon RT

更新日期：2000-01-15 00:00:00

abstract：:Endospores of Bacillus subtilis are encased in a two-layer protein shell known as the coat, which consists of a lammellar-like inner layer and an electron-dense outer layer. We report the cloning of the structural gene (designated cotE) for an alkali-soluble coat protein of 24 kD and show that the cotE gene product is...

journal_title：Genes & development

authors： Zheng LB,Donovan WP,Fitz-James PC,Losick R

更新日期：1988-08-01 00:00:00

abstract：:Start sites of DNA replication are marked by the origin recognition complex (ORC), which coordinates Mcm2-7 helicase loading to form the prereplicative complex (pre-RC). Although pre-RC assembly is well characterized in vitro, the process is poorly understood within the local chromatin environment surrounding replicat...

journal_title：Genes & development

authors： Belsky JA,MacAlpine HK,Lubelsky Y,Hartemink AJ,MacAlpine DM

更新日期：2015-01-15 00:00:00

abstract：:The myogenic regulatory factor MyoD dimerizes with other positive and negative regulatory factors through a conserved region called the helix-loop-helix (HLH) domain. Using a non-DNA-binding MyoD mutant with a normal HLH domain as a dimerization competitor in gel mobility shift assays in conjunction with various MyoD ...

journal_title：Genes & development

authors： Shirakata M,Friedman FK,Wei Q,Paterson BM

更新日期：1993-12-01 00:00:00

abstract：:The Rho family of small GTPases are critical elements involved in the regulation of signal transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK signaling pathway, the c-fos serum response factor, and the p70 S6 kinase. Here we report a novel signaling pathway activated by the Rh...

journal_title：Genes & development

authors： Perona R,Montaner S,Saniger L,Sánchez-Pérez I,Bravo R,Lacal JC

更新日期：1997-02-15 00:00:00

abstract：:Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers, including breast cancer. Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homozygously lost in some breast cancer patients. ...

journal_title：Genes & development

authors： Zhang S,Fan G,Hao Y,Hammell M,Wilkinson JE,Tonks NK

更新日期：2017-10-01 00:00:00

abstract：:Alteration of nucleosomes by ATP-dependent remodeling complexes represents a critical step in the regulation of transcription. The human SWI/SNF (hSWI/SNF) family is composed of complexes that contain either Brg1 or hBrm as the central ATPase; however, these separate complexes have not been compared functionally. Here...

journal_title：Genes & development

authors： Sif S,Saurin AJ,Imbalzano AN,Kingston RE

更新日期：2001-03-01 00:00:00

abstract：:The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-speci...

journal_title：Genes & development

authors： Dirksen ML,Jamrich M

更新日期：1992-04-01 00:00:00

abstract：:An RNA-based gene silencing pathway that protects bacteria and archaea from viruses and other genome invaders is hypothesized to arise from guide RNAs encoded by CRISPR loci and proteins encoded by the cas genes. CRISPR loci contain multiple short invader-derived sequences separated by short repeats. The presence of v...

journal_title：Genes & development

authors： Carte J,Wang R,Li H,Terns RM,Terns MP

更新日期：2008-12-15 00:00:00

abstract：:To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty-seven percent of the introns assayed manifest >50% cotranscriptional splicing. The remaining 13% are cotranscriptionally spliced poorly or slow...

journal_title：Genes & development

authors： Khodor YL,Rodriguez J,Abruzzi KC,Tang CH,Marr MT 2nd,Rosbash M

更新日期：2011-12-01 00:00:00

abstract：:Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that M...

journal_title：Genes & development

authors： Vourekas A,Zheng K,Fu Q,Maragkakis M,Alexiou P,Ma J,Pillai RS,Mourelatos Z,Wang PJ

更新日期：2015-03-15 00:00:00

abstract：:The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear...

journal_title：Genes & development

authors： Hepler C,Vishvanath L,Gupta RK

更新日期：2017-01-15 00:00:00

abstract：:We show the intracellular localization of the Escherichia coli replication origin (oriC) and chromosome terminus during the cell division cycle by FISH. In newborn cells, oriC is localized at the old-pole-proximal nucleoid border and the terminus at the new-pole-proximal nucleoid border. One copy of replicated oriC mi...

journal_title：Genes & development

authors： Niki H,Hiraga S

更新日期：1998-04-01 00:00:00

abstract：:The stage-specific embryonic antigen SSEA-1 is a cell-surface oligosaccharide molecule expressed with temporal precision during the murine preimplantation period and implicated in adhesive events involving the process of compaction. We used a mammalian transient expression system to isolate a cloned human cDNA that de...

journal_title：Genes & development

authors： Kukowska-Latallo JF,Larsen RD,Nair RP,Lowe JB

更新日期：1990-08-01 00:00:00

abstract：:Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as transcription factors that modify chromatin structure. In this work, we report new genetic and biochemical studies of Spt4, Spt5, and Spt6 that reveal a role for these factors in transcription e...

journal_title：Genes & development

authors： Hartzog GA,Wada T,Handa H,Winston F

更新日期：1998-02-01 00:00:00