Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.

abstract：:The bHLH-PAS transcription factor SIM1 is expressed during the development of the hypothalamic-pituitary axis in three hypothalamic nuclei: the paraventricular nucleus (PVN), the anterior periventricular nucleus (aPV), and the supraoptic nucleus (SON). To investigate Sim1 function in the hypothalamus, we produced mice...

journal_title：Genes & development

authors： Michaud JL,Rosenquist T,May NR,Fan CM

更新日期：1998-10-15 00:00:00

abstract：:Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that M...

journal_title：Genes & development

authors： Vourekas A,Zheng K,Fu Q,Maragkakis M,Alexiou P,Ma J,Pillai RS,Mourelatos Z,Wang PJ

更新日期：2015-03-15 00:00:00

abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...

journal_title：Genes & development

authors： Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella L

更新日期：2016-09-15 00:00:00

abstract：:We have investigated the DNA-binding, oligomerization, and trans-activation functions of isolated segments of murine p53. We find that p53 has two autonomous DNA-binding regions. One domain, from amino acid 280 to 390, forms stable tetramers and binds DNA nonspecifically. The biological significance, if any, of this D...

journal_title：Genes & development

authors： Wang Y,Reed M,Wang P,Stenger JE,Mayr G,Anderson ME,Schwedes JF,Tegtmeyer P

更新日期：1993-12-01 00:00:00

abstract：:Amplification of 8p11-12 in human breast cancers is associated with increased proliferation and tumor grade and reduced metastasis-free patient survival. We identified Zeppo1 (zinc finger elbow-related proline domain protein 1) (FLJ14299/ZNF703) within this amplicon as a regulator of cell adhesion, migration, and prol...

journal_title：Genes & development

authors： Slorach EM,Chou J,Werb Z

更新日期：2011-03-01 00:00:00

abstract：:We have analyzed pre-mRNA splicing in yeast extracts immunodepleted of the PRP18 protein. We find that while the first step of splicing (cleavage at the 5' splice site, and generation of the exon 1 and lariat intermediates) is unaffected by the absence of PRP18, the second step of splicing (excision of the lariat intr...

journal_title：Genes & development

authors： Horowitz DS,Abelson J

更新日期：1993-02-01 00:00:00

abstract：:Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein ...

journal_title：Genes & development

authors： Gartenberg MR

更新日期：2009-05-01 00:00:00

abstract：:The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

journal_title：Genes & development

authors： Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

更新日期：1995-09-01 00:00:00

abstract：:The Rho family of small GTPases are critical elements involved in the regulation of signal transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK signaling pathway, the c-fos serum response factor, and the p70 S6 kinase. Here we report a novel signaling pathway activated by the Rh...

journal_title：Genes & development

authors： Perona R,Montaner S,Saniger L,Sánchez-Pérez I,Bravo R,Lacal JC

更新日期：1997-02-15 00:00:00

abstract：:The incorporation of histone H1 into chromatin during embryogenesis directs the specific repression of the Xenopus oocyte 5S rRNA genes. An increase in histone H1 content specifically restricts TFIIIA-activated transcription, and a decrease in histone H1 within chromatin facilitates the activation of the oocyte 5S rRN...

journal_title：Genes & development

authors： Bouvet P,Dimitrov S,Wolffe AP

更新日期：1994-05-15 00:00:00

abstract：:Genetic analysis in Arabidopsis has led to the identification of several genes that are required for auxin response. One of these genes, AXR1, encodes a protein related to yeast Aos1p, a protein that functions to activate the ubiquitin-related protein Smt3p. Here we report the identification of a new gene called TRANS...

journal_title：Genes & development

authors： Ruegger M,Dewey E,Gray WM,Hobbie L,Turner J,Estelle M

更新日期：1998-01-15 00:00:00

abstract：:The SNF1 protein kinase is broadly conserved in eukaryotes and has been implicated in responses to environmental and nutritional stress. In yeast, the SNF1 kinase has a central role in the response to glucose starvation. SNF1 is associated with its activating subunit, SNF4, and other proteins in complexes. Using the t...

journal_title：Genes & development

authors： Jiang R,Carlson M

更新日期：1996-12-15 00:00:00

abstract：:Eukaryotic genomes encode large families of deubiquitinating enzymes (DUBs). Genetic data suggest that Fat facets (Faf), a Drosophila DUB essential for patterning the compound eye, might have a novel regulatory function; Faf might reverse the ubiquitination of a specific substrate, thereby preventing proteasomal degra...

journal_title：Genes & development

authors： Chen X,Zhang B,Fischer JA

更新日期：2002-02-01 00:00:00

abstract：:U6 small nuclear RNA is one of the spliceosomal RNAs involved in pre-mRNA splicing. In the fission yeast Schizosaccharomyces pombe, the U6 RNA gene was found to have an intron similar to a nuclear pre-mRNA intron, and it was proposed that the U6 intron might be inserted erroneously during pre-mRNA splicing. Using the ...

journal_title：Genes & development

authors： Tani T,Ohshima Y

更新日期：1991-06-01 00:00:00

abstract：:Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is established in the Drosophila female germ line. mRNA transcripts are translationally quiescent at the arrested oocyte stage and are insensitive to RNAi. Upon oocyte...

journal_title：Genes & development

authors： Kennerdell JR,Yamaguchi S,Carthew RW

更新日期：2002-08-01 00:00:00

abstract：:Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for de...

journal_title：Genes & development

authors： Kaiser P,Sia RA,Bardes EG,Lew DJ,Reed SI

更新日期：1998-08-15 00:00:00

abstract：:Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of ...

journal_title：Genes & development

authors： Jiménez G,González-Reyes A,Casanova J

更新日期：2002-04-15 00:00:00

abstract：:DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian...

journal_title：Genes & development

authors： Gachon F,Fonjallaz P,Damiola F,Gos P,Kodama T,Zakany J,Duboule D,Petit B,Tafti M,Schibler U

更新日期：2004-06-15 00:00:00

abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

journal_title：Genes & development

authors： Hubbard EJ,Wu G,Kitajewski J,Greenwald I

更新日期：1997-12-01 00:00:00

abstract：:The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant o...

journal_title：Genes & development

authors： Moore AW,Roegiers F,Jan LY,Jan YN

更新日期：2004-03-15 00:00:00

abstract：:Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of approximately 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class o...

journal_title：Genes & development

authors： Grivna ST,Beyret E,Wang Z,Lin H

更新日期：2006-07-01 00:00:00

abstract：:The conserved RCN family of proteins can bind and directly regulate calcineurin, a Ca(2+)-activated protein phosphatase involved in immunity, heart growth, muscle development, learning, and other processes. Whereas high levels of RCNs can inhibit calcineurin signaling in fungal and animal cells, RCNs can also stimulat...

journal_title：Genes & development

authors： Hilioti Z,Gallagher DA,Low-Nam ST,Ramaswamy P,Gajer P,Kingsbury TJ,Birchwood CJ,Levchenko A,Cunningham KW

更新日期：2004-01-01 00:00:00

abstract：:The distal enhancer of the T-cell receptor (TCR) alpha chain gene has become a paradigm for studies of the assembly and activity of architectural enhancer complexes. Here we have reconstituted regulated TCR alpha enhancer activity in vitro on chromatin templates using purified T-cell transcription factors (LEF-1, AML1...

journal_title：Genes & development

authors： Mayall TP,Sheridan PL,Montminy MR,Jones KA

更新日期：1997-04-01 00:00:00

abstract：:X. laevis stage VI oocytes respond differently from unfertilized eggs when injected with the genes for X. laevis embryonic U1 RNAs, xU1b1, and xU1b2. Upon maturation of oocytes into eggs, the efficiency of transcription decreases greatly and the ratio of xU1b1 to xU1b2 RNA transcription changes. Moreover, DNA replicat...

journal_title：Genes & development

authors： Lund E,Bostock CJ,Dahlberg JE

更新日期：1987-03-01 00:00:00

abstract：:Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arres...

journal_title：Genes & development

authors： Tomita K,Hattori M,Nakamura E,Nakanishi S,Minato N,Kageyama R

更新日期：1999-05-01 00:00:00

abstract：:Irradiation in the G1 phase of the cell cycle delays the onset of DNA synthesis and transiently inhibits the activation of replication origins in mammalian cells. It has been suggested that this inhibition is the result of the loss of torsional tension in the DNA after it has been damaged. Because irradiation causes D...

journal_title：Genes & development

authors： Raghuraman MK,Brewer BJ,Fangman WL

更新日期：1994-03-01 00:00:00

abstract：:Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. In this issue of Genes & Development, Tovy and colleagues (pp. 959-972) report that, in naïve mo...

journal_title：Genes & development

authors： Laptenko O,Prives C

更新日期：2017-05-15 00:00:00

abstract：:Transgenic mice expressing wild-type murine p53 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) undergo progressive renal failure due to abnormal kidney development. Similar phenotypes are observed in two transgenic lines that express wild-type p53 within the ureteric bud but not in ...

journal_title：Genes & development

authors： Godley LA,Kopp JB,Eckhaus M,Paglino JJ,Owens J,Varmus HE

更新日期：1996-04-01 00:00:00

abstract：:A Drosophila FGF receptor homolog (DFGF-R2/DFRI) termed Heartless (Htl) is expressed in the embryonic mesoderm. The phenotypes of null mutant embryos demonstrated that Htl is a central player that is required for the development of several mesodermal lineages. No abnormalities in the primary specification of the mesod...

journal_title：Genes & development

authors： Beiman M,Shilo BZ,Volk T

更新日期：1996-12-01 00:00:00

abstract：:An RNA-binding protein gene (rbp1) from Drosophila melanogaster, encoding an RNA recognition motif and an Arg-Ser rich (RS) domain, has been characterized. The predicted amino acid sequence of rbp1 is similar to those of the human splicing factor ASF/SF2, the Drosophila nuclear phosphoprotein SRp55, and the Drosophila...

journal_title：Genes & development

authors： Kim YJ,Zuo P,Manley JL,Baker BS

更新日期：1992-12-01 00:00:00