Gonadotropin gene expression and secretion in gonadotropin-releasing hormone antagonist-treated male rats: effect of sex steroid replacement.

abstract：:The perinatal rat exhibits low serum TSH levels in the presence of very low concentrations of T3 and T4. We had reported previously that this animal does not require endogenous TRH for TSH release. We investigated here whether the inhibitory hormone somatostatin (SS) has a role in maintaining the low TSH secretory set...

journal_title：Endocrinology

authors： Theodoropoulos TJ

更新日期：1985-10-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...

journal_title：Endocrinology

authors： Eshkevari L,Mulroney SE,Egan R,Lao L

更新日期：2015-10-01 00:00:00

abstract：:Synthesis of uteroglobin in rabbit uterine epithelial cells during early pregnancy is induced by progesterone and apparently suppressed by estrogen. To assess whether the steroid hormones exert regulatory effects on the expression of the uteroglobin gene, we performed transcriptional rate assays in endometrial nuclei ...

journal_title：Endocrinology

authors： Shen XZ,Tsai MJ,Bullock DW,Woo SL

更新日期：1983-03-01 00:00:00

abstract：:Although the neurohypophyseal hormone oxytocin (OT) is best know for its role in reproduction, OT also stimulates natriuresis at physiological plasma levels. This effect is mediated via specific renal OT receptors (OTRs). In the present study, we have characterized rat renal OTR gene transcripts and assessed their reg...

journal_title：Endocrinology

authors： Breton C,Neculcea J,Zingg HH

更新日期：1996-07-01 00:00:00

abstract：:Small amounts of TRH are present in the thyroid, and TRH has been shown in several studies to have a moderate direct inhibitory effect on TSH-stimulated thyroid hormone secretion. In a recent publication, however, data were presented to demonstrate that very low doses of TRH given in short pulses induce immediate incr...

journal_title：Endocrinology

authors： Iversen E,Laurberg P

更新日期：1988-02-01 00:00:00

abstract：:We have demonstrated two heat shock proteins (HSP's) in the human placenta that specifically bind calcitonin. Binding specificity was shown by ligand-affinity chromatography and by competitive binding studies. The HSP's were identified by Western analysis and by amino acid sequence. Our observations are consistent wit...

journal_title：Endocrinology

authors： Dana RC,Welch WJ,Deftos LJ

更新日期：1990-01-01 00:00:00

abstract：:AtT20/D16v is a clonal strain of mouse pituitary tumor cells which synthesizes and secretes ACTH. Somatostatin, a hypothalamic tetradecapeptide, has been shown to inhibit the release of PRL, GH, and TSH from the pituitary gland. We have characterized specific binding sites for somatostatin on AtT20/D16v cells and demo...

journal_title：Endocrinology

authors： Richardson UI,Schonbrunn A

更新日期：1981-01-01 00:00:00

abstract：:Previous descriptions of pulsatile LH release in immature female rats have been mostly inaccurate because of infrequent blood sampling, discontinuous and unbalanced blood replacement procedures, and possibly because of the use of a heterologous RIA. The present study was undertaken to circumvent these problems and to ...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1985-08-01 00:00:00

abstract：:Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...

journal_title：Endocrinology

authors： Herrera GGB,Lierz SL,Harris EA,Donoghue LJ,Hewitt SC,Rodriguez KF,Jefferson WN,Lydon JP,DeMayo FJ,Williams CJ,Korach KS,Winuthayanon W

更新日期：2020-02-01 00:00:00

abstract：:To investigate GH's role in diabetic end organ damage, experimental diabetes was induced with streptozotocin (STZ) in bovine GH (bGH) or bGH antagonist transgenic mice and in their nontransgenic (NTG) litter mates. Body growth, blood glucose, serum insulin-like growth factor-I levels, liver GH receptor (GHR) binding, ...

journal_title：Endocrinology

authors： Chen NY,Chen WY,Bellush L,Yang CW,Striker LJ,Striker GE,Kopchick JJ

更新日期：1995-02-01 00:00:00

abstract：:SH2B1 is an SH2 domain-containing adaptor protein that plays a key role in the regulation of energy and glucose metabolism in both rodents and humans. Genetic deletion of SH2B1 in mice results in obesity and type 2 diabetes. Single-nucleotide polymorphisms in the SH2B1 loci and chromosomal deletions of the SH2B1 loci ...

journal_title：Endocrinology

authors： Morris DL,Cho KW,Rui L

更新日期：2010-08-01 00:00:00

abstract：:A time-course study was performed to correlate serum gonadotropin changes after ovariectomy (OVX) or OVX plus acute estradiol (E2) treatment with LHRH content and norepinephrine (NE) and dopamine (DA) content and turnover in the suprachiasmatic-medial preoptic region (SCH-PO), the medial basal hypothalamus (MBH), and ...

journal_title：Endocrinology

authors： Advis JP,McCann SM,Negro-Vilar A

更新日期：1980-10-01 00:00:00

abstract：:The present investigation was undertaken to examine the possible role of cAMP in PTH-stimulated prostaglandin (PG) production in organ cultures of neonatal mouse parietal bones. Cultures were treated with PTH, forskolin, isobutylmethylxanthine (IBMX), and 8-bromo-cAMP (8BrcAMP). We found that similar concentrations of...

journal_title：Endocrinology

authors： Klein-Nulend J,Bowers PN,Raisz LG

更新日期：1990-02-01 00:00:00

abstract：:Pulmonary surfactant is a developmentally and hormonally regulated lipoprotein synthesized exclusively in alveolar type II cells. Surfactant protein-A (SP-A) gene transcription in human fetal lung in culture is stimulated by glucocorticoids and cAMP; cAMP also enhances the rate of type II cell differentiation. The CCA...

journal_title：Endocrinology

authors： Breed DR,Margraf LR,Alcorn JL,Mendelson CR

更新日期：1997-12-01 00:00:00

abstract：:Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. Chronic repercussions of ApN treatment or overexpression on adiposity and body weight are still controversial. Here, we generated a transgenic (Tg) mouse model allowing persistent and mod...

journal_title：Endocrinology

authors： Bauche IB,El Mkadem SA,Pottier AM,Senou M,Many MC,Rezsohazy R,Penicaud L,Maeda N,Funahashi T,Brichard SM

更新日期：2007-04-01 00:00:00

abstract：:Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in ad...

journal_title：Endocrinology

authors： Laroche J,Gasbarro L,Herman JP,Blaustein JD

更新日期：2009-05-01 00:00:00

abstract：:While uterine stromal cells (USC) appear to modify the function of uterine epithelial cells (UEC) under certain conditions in vivo, relatively little is known about the effect of epithelial cells on stromal cell differentiation and function. To determine if UEC modulate USC function in vitro, highly enriched (> 95%) c...

journal_title：Endocrinology

authors： Wegner CC,Carson DD

更新日期：1992-12-01 00:00:00

abstract：:Morphological plasticity in response to estradiol is a hallmark of astrocytes in the arcuate nucleus. The functional consequences of these morphological changes have remained relatively unexplored. Here we report that in the arcuate nucleus estradiol significantly increased the protein levels of the two enzymes in the...

journal_title：Endocrinology

authors： Blutstein T,Baab PJ,Zielke HR,Mong JA

更新日期：2009-07-01 00:00:00

abstract：:The adrenal medulla contains fenestrated capillaries that allow catecholamines and neuropeptides secreted by adrenal chromaffin cells (ACCs) to readily access the circulation. These capillaries may also allow bacterial products to enter the adrenal medulla and interact with ACCs during infection. One potential mediato...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2013-01-01 00:00:00

abstract：:Administration of GH increases both the tubular reabsorption of inorganic phosphate (Pi) and the plasma level of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. These two effects could be induced by a common mediator, possibly the GH-generated insulin-like growth factor 1 (IGF-1). In the present work, the influence of recomb...

journal_title：Endocrinology

authors： Caverzasio J,Montessuit C,Bonjour JP

更新日期：1990-07-01 00:00:00

abstract：:Over 6 billion pounds per year of the estrogenic monomer bisphenol A (BPA) are used to manufacture polycarbonate plastic products, in resins lining metal cans, in dental sealants, and in blends with other types of plastic products. The ester bond linking BPA molecules in polycarbonate and resins undergoes hydrolysis, ...

journal_title：Endocrinology

authors： Welshons WV,Nagel SC,vom Saal FS

更新日期：2006-06-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00

abstract：:Ovary-specific acidic protein (OSAP) is a novel molecule discovered from a genomic project designed to identify ovary-selective genes in mice. Whereas public databases suggest extraovarian expression of OSAP, its tissue distribution has not yet been well documented. Thus, the expression profile of mouse and human OSAP...

journal_title：Endocrinology

authors： Matsumoto T,Minegishi K,Ishimoto H,Tanaka M,Hennebold JD,Teranishi T,Hattori Y,Furuya M,Higuchi T,Asai S,Kim SH,Miyakoshi K,Yoshimura Y

更新日期：2009-07-01 00:00:00

abstract：:The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...

journal_title：Endocrinology

authors： Pescovitz OH,Berry SA,Laudon M,Ben-Jonathan N,Martin-Myers A,Hsu SM,Lambros TJ,Felix AM

更新日期：1990-11-01 00:00:00

abstract：:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities ...

journal_title：Endocrinology

authors： Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll AP

更新日期：2006-12-01 00:00:00

abstract：:Although it is known that LH secretion starts at 17 days of gestation in the fetal rat and that this first LH release is most likely driven by hypothalamic GnRH, an earlier role for GnRH during fetal life has been postulated with the observation that presence of GnRH is important before day 13 of gestation for the dif...

journal_title：Endocrinology

authors： Aubert ML,Begeot M,Winiger BP,Morel G,Sizonenko PC,Dubois PM

更新日期：1985-04-01 00:00:00

abstract：:In developed countries, the increasing incidence of obesity is a serious health problem. Leptin exposure in the perinatal period affects long-term regulation of appetite and energy expenditure, but control of leptin production in utero is unclear. This study investigated perirenal adipose tissue (PAT) and placental le...

journal_title：Endocrinology

authors： O'Connor DM,Blache D,Hoggard N,Brookes E,Wooding FB,Fowden AL,Forhead AJ

更新日期：2007-08-01 00:00:00

abstract：:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evalua...

journal_title：Endocrinology

authors： Montgomery DW,Krumenacker JS,Buckley AR

更新日期：1998-02-01 00:00:00

abstract：:The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three different strains of the cell line D1, D16v, and D16:16, respectively, were analyzed. In initial studies CRF and phorbol esters were used as secretagogues to examine...

journal_title：Endocrinology

authors： Woods MD,Shipston MJ,Mullens EL,Antoni FA

更新日期：1992-12-01 00:00:00