Heat shock proteins bind calcitonin.

Abstract:

:We have demonstrated two heat shock proteins (HSP's) in the human placenta that specifically bind calcitonin. Binding specificity was shown by ligand-affinity chromatography and by competitive binding studies. The HSP's were identified by Western analysis and by amino acid sequence. Our observations are consistent with the hypothesis that HSP's may function by binding and interacting with cellular proteins and peptides during their biogenesis. This interaction may both depend upon and produce conformational changes in these ligands during their intracellular processing. Additionally, HSP-peptide hormone interactions may confound studies designed to investigate classical receptor-hormone interactions.

journal_name

Endocrinology

journal_title

Endocrinology

authors

Dana RC,Welch WJ,Deftos LJ

doi

10.1210/endo-126-1-672

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

672-4

issue

1

eissn

0013-7227

issn

1945-7170

journal_volume

126

pub_type

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