Abstract:
:We have demonstrated two heat shock proteins (HSP's) in the human placenta that specifically bind calcitonin. Binding specificity was shown by ligand-affinity chromatography and by competitive binding studies. The HSP's were identified by Western analysis and by amino acid sequence. Our observations are consistent with the hypothesis that HSP's may function by binding and interacting with cellular proteins and peptides during their biogenesis. This interaction may both depend upon and produce conformational changes in these ligands during their intracellular processing. Additionally, HSP-peptide hormone interactions may confound studies designed to investigate classical receptor-hormone interactions.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Dana RC,Welch WJ,Deftos LJdoi
10.1210/endo-126-1-672subject
Has Abstractpub_date
1990-01-01 00:00:00pages
672-4issue
1eissn
0013-7227issn
1945-7170journal_volume
126pub_type
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