Differential expression of perforin in cytotoxic lymphocyte in HIV/AIDS patients of China.

abstract：:The aim of this study was to research the expression of IL-37 in systemic lupus erythematosus (SLE) patients and the effect of glucocorticoid on IL-37. Thirty newly diagnosed severe SLE patients receiving prednisone 1 mg/kg/day for 14 consecutive days and 30 healthy subjects were enrolled into this study. The plasma l...

journal_title：Journal of clinical immunology

authors： Song L,Qiu F,Fan Y,Ding F,Liu H,Shu Q,Liu W,Li X

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Complement deficiencies are rare primary immunodeficiency disorders, the diagnosis of which is often underestimated. Only a small number of molecular studies have been carried out for the characterization of the underlying genetic defects in these cases. PURPOSE:Reporting the first family from the Arabian...

journal_title：Journal of clinical immunology

authors： Arnaout R,Al Shorbaghi S,Al Dhekri H,Al-Mousa H,Al Ghonaium A,Al Saud B,Al Muhsen S,Al Baik L,Hawwari A

更新日期：2013-05-01 00:00:00

abstract：:Increased levels of serum IgD can be found in single patients with a variety of clinical syndromes and in the disease entity designated hyper-IgD syndrome which is associated with periodic fever and lymphadenopathy. We investigated 17 patients, both children and adults, with high serum IgD levels ranging from 220 to 5...

journal_title：Journal of clinical immunology

authors： Hiemstra I,Vossen JM,van der Meer JW,Weemaes CM,Out TA,Zegers BJ

更新日期：1989-09-01 00:00:00

abstract：:Apart from cellular immunity and immunopathology, various cytokines have been implicated in malaria-associated immunosuppression. In this study, serum levels of transforming growth factor-beta (TGF-beta) were determined with an enzyme-linked immunosorbent assay in 37 patients with acute Plasmodium falciparum malaria p...

journal_title：Journal of clinical immunology

authors： Wenisch C,Parschalk B,Burgmann H,Looareesuwan S,Graninger W

更新日期：1995-03-01 00:00:00

abstract：:Glucocorticoids (GC) represent the main treatment for pemphigus; however, some patients show GC resistance. GC sensitivity was evaluated in 19 pemphigus patients and 41 controls by the number of binding sites [B(max) (fmol/mg protein)] and the affinity of GC receptor [Kd (nM)] to dexamethasone (DEX) as well as by the ...

journal_title：Journal of clinical immunology

authors： Chriguer RS,Roselino AM,de Castro M

更新日期：2012-08-01 00:00:00

abstract：:The first description of the hybridoma technology in 1975 seemed to hold enormous promise for the treatment of a variety of human disease. The ability to produce monoclonal antibodies led to the availability of large amounts of homogeneous and predictable preparations of antibody. The potential to renew indefinitely a...

journal_title：Journal of clinical immunology

authors： Pirofski L,Casadevall A,Rodriguez L,Zuckier LS,Scharff MD

更新日期：1990-11-01 00:00:00

abstract：:Cross-sectional and limited sequential studies of neutrophil and monocyte chemotaxis were done using cells isolated from cord blood and peripheral blood of 2- to 6-day-old neonates and infants at 4 and 6 months of age. These studies show that cord blood phagocyte chemotaxis is comparable to adult values, whereas phago...

journal_title：Journal of clinical immunology

authors： Raghunathan R,Miller ME,Everett S,Leake RD

更新日期：1982-07-01 00:00:00

abstract：:Total levels of IgM and secretory IgM as well as specific antibodies to poliovirus type I antigen, Escherichia coli O antigens, and beta-lactoglobulin were measured in unstimulated and stimulated saliva as well as nasal secretion using an enzyme-linked immunosorbent assay (ELISA). The levels of these antibodies in IgA...

journal_title：Journal of clinical immunology

authors： Mellander L,Björkander J,Carlsson B,Hanson LA

更新日期：1986-07-01 00:00:00

abstract：:Matrix metalloproteinases (also named matrixin or MMPs) are a major group of enzymes that regulate cell-matrix composition by using zinc for their proteolytic activities. They are essential for various normal biological processes such as embryonic development, morphogenesis, reproduction tissue resorption, and remodel...

journal_title：Journal of clinical immunology

authors： Ram M,Sherer Y,Shoenfeld Y

更新日期：2006-07-01 00:00:00

abstract：:Autism is a complex polygenic neurodevelopmental disorder characterized by deficits in communication and social interactions as well as specific stereotypical behaviors. Both genetic and environmental factors appear to contribute to the pathogenesis of autism. Accumulating data including changes in immune responses, l...

journal_title：Journal of clinical immunology

authors： Gupta S,Samra D,Agrawal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Combined immunodeficiency (CID) presents a unique challenge to clinicians. Two patients presented with the prior clinical diagnosis of common variable immunodeficiency (CVID) disorder marked by an early age of presentation, opportunistic infections, and persistent lymphopenia. Due to the presence of atypical cl...

journal_title：Journal of clinical immunology

authors： Buchbinder D,Baker R,Lee YN,Ravell J,Zhang Y,McElwee J,Nugent D,Coonrod EM,Durtschi JD,Augustine NH,Voelkerding KV,Csomos K,Rosen L,Browne S,Walter JE,Notarangelo LD,Hill HR,Kumánovics A

更新日期：2015-02-01 00:00:00

abstract：:CFSE dye dilution analysis and [3H] thymidine incorporation were used side by side to assess proliferative responses of peripheral blood mononuclear cells (PBMCs) after vaccination of renal cell carcinoma patients (n=6) with antigen-loaded dendritic cells. Immune responses against the control antigen keyhole limpet he...

journal_title：Journal of clinical immunology

authors： Putz T,Ramoner R,Gander H,Rahm A,Bartsch G,Höltl L,Thurnher M

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Poikiloderma with neutropenia (PN) is a genodermatosis currently described in 77 patients, all presenting with early-onset poikiloderma, neutropenia, and several additional signs. Biallelic loss-of-function mutations in USB1 gene are detected in all molecularly tested patients but genotype-phenotype correlation...

journal_title：Journal of clinical immunology

authors： Colombo EA,Elcioglu NH,Graziano C,Farinelli P,Di Fede E,Neri I,Facchini E,Greco M,Gervasini C,Larizza L

更新日期：2018-05-01 00:00:00

abstract：:Two hundred twelve patients with enzyme immunoassay and Western blot confirmation of human immunodeficiency virus (HIV) infection were evaluated with anergy panel, lymphocyte cell surface phenotyping, lymphocyte transformation, and serum immunoglobulins. Mitogen responses were used to develop a lymphocyte transformati...

journal_title：Journal of clinical immunology

authors： Ridley DJ,Houk RW,Reid MJ,Boswell RN

更新日期：1989-03-01 00:00:00

abstract：:There has been a growing body of evidence suggesting that CD4+ Th1/Th2 cell responses participate in pathologic and immunologic processes in infectious disease. Bacterial meningitis is a fatal disease of children and is associated with a spectrum of clinical syndromes. This study provides evidence of CD4+ enhanced int...

journal_title：Journal of clinical immunology

authors： Raziuddin S,el-Awad ME,Telmesani AW,Bilal NE,al-Janadi M

更新日期：1995-11-01 00:00:00

abstract：:Thirty two HIV-infected children, on highly active antiretroviral therapy (HAART) and > 500 CD4+ T cells/mm3, were rated according to the time-course of viral load (VL) during the whole follow-up period (> 18 months) in a longitudinal retrospective study. (a) uVL group: 15 children with VL below 400 copies/mL; (b) dVL...

journal_title：Journal of clinical immunology

authors： Resino S,Galán I,Bellón JM,Navarro ML,León JA,Muñoz-Fernandez MA

更新日期：2003-07-01 00:00:00

abstract：:The etiology of immunodeficiency following trauma was investigated. Plasma collected from Fischer rats 1-8 hr following a 40% surface area thermal injury (TI) displays immunosuppressive activity (ISA). Peak ISA (4 hr) exceeded 90% inhibition of Con A3-induced proliferation of normal spleen cells. Splenic macrophage IL...

journal_title：Journal of clinical immunology

authors： Mills CD,Caldwell MD,Gann DS

更新日期：1989-03-01 00:00:00

abstract：:The inflammasome is an intracellular multimolecular complex that controls caspase-1 activity in the innate immune system. NLRP3, a member of the NLR family of cytosolic pattern recognition receptors, along with the adaptor protein ASC, mediates caspase-1 activation via assembly of the inflammasome in response to vario...

journal_title：Journal of clinical immunology

authors： Jin C,Flavell RA

更新日期：2010-09-01 00:00:00

abstract：:Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 backgro...

journal_title：Journal of clinical immunology

authors： Parker J,Menn-Josephy H,Laskow B,Takemura Y,Aprahamian T

更新日期：2011-04-01 00:00:00

abstract：:The expression of chemokine receptors on leukocytes is related to their activation state. However, the exact mechanism underlying the induction of each chemokine receptor is poorly understood. Here, we investigated how CCR5, a chemokine receptor implicated in T cell trafficking and HIV infection, is induced in human T...

journal_title：Journal of clinical immunology

authors： Yang YF,Tomura M,Iwasaki M,Mukai T,Gao P,Ono S,Zou JP,Shearer GM,Fujiwara H,Hamaoka T

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:Gastrointestinal manifestations are frequent in patients with common variable immunodeficiency (CVID), and some of the patients present with celiac-like features. Diagnosing celiac disease (CD) in CVID however is challenging, as autoantibody detection and histopathology of the small intestine cannot reliably...

journal_title：Journal of clinical immunology

authors： Venhoff N,Emmerich F,Neagu M,Salzer U,Koehn C,Driever S,Kreisel W,Rizzi M,Effelsberg NM,Kollert F,Goldacker S,Voll RE,Warnatz K,Thiel J

更新日期：2013-07-01 00:00:00

abstract：:Rat T lymphoblasts arrested in the G1 phase of the cell cycle by interleukin-2 (IL-2) deprivation can be forced to proceed to the S phase when they are stimulated with IL-2 or the phorbol ester phorbol 12,13-dibutyrate (PDBu). When PDBu is used as a stimulus, extracellular regulated kinase 2 (ERK2) is activated by thr...

journal_title：Journal of clinical immunology

authors： Lisbona C,Alemany S,Fernández-Renart M

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Hemophagocytic lymphohistiocytosis (HLH) is a rare systematic immune disease manifested with excessive activation of lymphocytes and macrophages. This study was designed to explore the feasible prognostic factors of secondary HLH (sHLH). METHOD:We retrospectively analyzed 179 patients with newly diagnosed sHLH...

journal_title：Journal of clinical immunology

authors： Huang J,Yin G,Duan L,Tian T,Xu J,Wang J,Gao X,Cheng W,Liu L,Qiu H

更新日期：2020-07-01 00:00:00

abstract：:The immune system is affected by the aging process and undergoes significant age-related changes, termed immunosenescence. Different T cell subsets are affected by this process. Alterations within the bone marrow and thymus lead to a shift in the composition of the T cell repertoire from naïve to antigen-experienced T...

journal_title：Journal of clinical immunology

authors： Arnold CR,Wolf J,Brunner S,Herndler-Brandstetter D,Grubeck-Loebenstein B

更新日期：2011-04-01 00:00:00

abstract：:Oral tolerance is the immunologic mechanism by which the mucosal immune system maintains unresponsiveness to the myriad of antigens in the mucosal environment which might otherwise induce untoward immune responses. Recent studies have shown that it is mediated by several distinct, yet interacting mechanisms including ...

journal_title：Journal of clinical immunology

authors： Strober W,Kelsall B,Marth T

更新日期：1998-01-01 00:00:00

abstract：:Murine hematopoietic tissues contain cells which, upon injection into lethally irradiated mice, produce nodules on the surface of their spleen (colony-forming unit--spleen; CFU-S). The exact hierarchical level of the hematopoietic progenitors which give rise to CFU-S is not fully established; however, cell populations...

journal_title：Journal of clinical immunology

authors： Rezzoug F,Tocci A,Safsafi K,Vivier G,Touraine JL

更新日期：1997-05-01 00:00:00

abstract：:Rapidly progressive glomerulonephritis (RPGN) is characterized by rapid and progressive loss of renal function and the presence of crescentic glomerulonephritis (CGN). Early diagnosis and appropriate treatment is mandatory to prevent death and/or renal failure. We have evaluated an ANCA-GBM dot-blot diagnostic test in...

journal_title：Journal of clinical immunology

authors： Rutgers A,Damoiseaux J,Roozendaal C,Limburg PC,Stegeman CA,Tervaert JW

更新日期：2004-07-01 00:00:00

abstract：:Human papillomavirus (HPV) infects the transformation zone of the cervix and is the primary cause of cervical cancer. The infection is localized to the cervix and mucosal immunity is likely to be an important determinant for viral clearance. Previous studies of immunity to HPV have measured immune markers in the blood...

journal_title：Journal of clinical immunology

authors： Castle PE,Hildesheim A,Bowman FP,Strickler HD,Walker JL,Pustilnik T,Edwards RP,Crowley-Nowick PA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:The dysregulated expression of miRNAs in the immune system may be critical for immune responses to pathogens and evolve into the inflammation seen in sepsis. The aim of this study is to explore the important role of miRNAs in the regulation of the immune response during neonatal sepsis. METHODS:Using a microar...

journal_title：Journal of clinical immunology

authors： Chen J,Jiang S,Cao Y,Yang Y

更新日期：2014-04-01 00:00:00

abstract：:The effects of the addition of indomethacin and interleukin-2 (IL-2) to phytohemagglutinin (PHA)-stimulated lymphocytes from patients with untreated squamous-cell carcinoma of the lung and with chronic obstructive pulmonary disease and from normal individuals were studied. In 13 of 21 patients with lung carcinoma, the...

journal_title：Journal of clinical immunology

authors： Maca RD,Burford JG,Taylor RT

更新日期：1985-05-01 00:00:00